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X. Structure and Function of the cell II
biology part 2
40
Anatomy
Undergraduate 2
09/21/2013

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Term
Interphase contains
Definition
G1, S, G2
Term
G1 phase
Definition
synthesis of proteins; centriole replication
Term
S
Definition
DNA replicates itself
Term
G2 phase
Definition
synthesis of machinery necessary for cell division; complete centriole "maturation
Term
semiconservative replication
Definition
each strand of existing DNA serves as a template for replication of a new strand of DNA. At the end of replication process,two double helix DNAs have been formed from the original DNA
Term
Helicase enzyme
Definition
unwind and separate the two strands of DNA
Term
Replication of dna begins with what?
Definition
formation of RNA primer performed by a primase enzyme and then the DNA polymerase can mind to RNA primer
Term
Which strand does DNA polymerase synthesize?
Definition
Leading strange, continuous and smooth
because DNA molecule has a specific polarity or oreination
Term
What is the function of the ligase enzyme?
Definition
ties together the fragments of the lagging strand called Okazaki fragments to complete continuity of the replicated DNA
Term
Finally the histone proteins reconfigure around the newly duplicated DNA
Definition
Term
Chromatid
Definition
duplicated halves of the DNA are now referred to as sister chromatids they are joined in the center by centromere to form final chromosome
Term
Prophase
Definition
organization of mitotic spindles
centrioles separate; extend microtubules, nuclear membrane breaks up
Term
where do microtubules attach to?
Definition
part of centromere called kinetochore
Term
kinetochore
Definition
unique sequence of DNA bound to protein
Term
metaphase
Definition
chromosomes aligned in center, microtubules extend from kinetochores of centromers of chomosome to centrioles. each side
Term
anaphase
Definition
separation of sister chromatids "pulled" by microtubules
Term
telophase
Definition
uncoild chromosome, reform nuclear membrane around daughter chromosomes
Term
Cytokinesis, what causes cleavage furrow and squeezes cell apart
Definition
cell membrane division to two daughter cells
actin
Term
name control mechanisms which limit cell replication
Definition
surface to volume ratio- critical cell size, inadequate meeting of nutritional needs
contact inhibition- stops proliferation, when cells touch e/o stops multiplying/rapidly process
regulatory proteins- proteins whose concentrations and or activity increase/decrease thorughout cell cycle to effect preparation and execution of cell division
cyclins
cdk-cylcin dependent kinases
Term
Does cyclin increase, decrease, both, or stay constant during cell cycle?
Definition
increase and decrease concentration of cyclin
Term
Are cdks constant or vary during cell cycle?
Definition
constant
Term
DNA serves as the blueprint for protein synthesis
Definition
Term
Gene
Definition
a segment of DNA which serves as the blueprint for a single polypeptide

blueprint for each amino acid is 1 triplet of DNA as shown
Term
Transcription
Definition
synthesisze mRNA from DNA template in order to transfer info from DNA to RNA. Occurs in the nucleus
Term
Translation
Definition
synthesize a protein off of mRNA template. Occurs in cytoplasm. Uses mRNA, tRNA, and ribosome
Term
Which base is exposed during transcription?
Definition
nitrogen

DNA molecule is unzipped and nitrogen bases are exposed
RNA polymerase- synthesizes mRNA; complimentary base pairing; G:C, A:U
Term
What is the role of RNA polymerase in transcription
Definition
synthesizes mRNA;
Term
mRNA is a mirror image of DNA
Definition
Term
codon
Definition
three sequential bases reprsent this, which will ultimately code for an amino acid. many codons are found on one mRNA strand
Term
The synthesized product of transcription is actually a pre-mRNA which is edited or shortened to form the mRNA which will be used for transcription
Definition
Term
introns
Definition
non-informational regions;edited out
Term
extrons
Definition
informational regions; left in and spliced together
Term
translation
Definition
ribosomes bind with mRNA to begin process of translation. Ribosomes contain two subunits large and small
Term
Which is the first binding site for tRNA
Definition
P-site
Term
What is the 2nd binding sight for tRNA
Definition
A-site
Term
3rd binding site for tRNA?
Definition
E site
Term
What does the tRNA carry?
Definition
anticodons and amino acid
each anticodon is specific for each amino acid
Term
polyribosome
Definition
multiple ribosomes can bind with mRNA; allows formation of multiple copies of a specific protein from one template
Term
Extracellualr material
Definition
fluid and matrix which make up connective tissue
Term
developmental aspect of cells
Definition
cell differentiation
hyperplasia - number of cells increase
hypertrophy- size of cell increase
atrophy- los of size/no longer functional
cell aging and apoptosis
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