Term
| Are polarized drugs more readily excreted? |
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Definition
YES....ionized drugs or metabolites cannot back diffuse & are excreted
NON-ionized portion of drug may diffuse from renal tubulbe back into blood |
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Term
Name 3 examples of pro-drugs?
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Definition
Cyclophosphamide
carbamazepine
PPIs
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Term
| Name one drug that is active & it's metabolite is active also. |
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Definition
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Term
Name 6 1st generation antihistamines.
Compare sedation (S), anti-emetic (A) and treatment (TX) |
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Definition
Drug S A TX
chlopheniramine ++ 0 -diphenhydrinate +++ ++ MS
diphenhydramine +++ ++ MS, I
hydroxyzine +++ +++ A, PIT
meclizine ++ +++ V, MS
promethazine +++ +++ N/V
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Term
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Definition
NASAL spray::
azelastine (Astelin)
olipatadine
EYE drops::::
bepostastine
emedastine |
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Term
H2 Receptor Antagonist
name 4 |
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Definition
cimetidine
ranitidine
famotidine
nizatidine |
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Term
name substrates of CYP2D6
Accounts for about 30% of drug oxidations |
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Definition
eg of drugs
antipsychotics...haloperidol
Beta blockers...carvediol
opioid analgersics..codeine
antidepressant...fluoxetine |
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Term
| Name 4 inhibitors of CYP2D6 |
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Definition
quinidine
cimetidine
fluoxetine
paroxetine |
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Term
Name 2 drugs metabolized by CYP2E1
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Definition
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Term
Name 2 substrates and
2 drugs that inhibit
CYP1A1 & CYP1A2 |
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Definition
substrates:
warfarin
ciprofloxacin
Inhibitors:
fluoxetine
cimetidine |
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Term
Name 1 drug that inhibits
CYP2A6 & CYP2B6
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Definition
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Term
Name 2 drugs that inhibit CYP2C9
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Definition
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Term
| Name 2 drugs that inhibit CYP2C19 |
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Definition
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Term
|
Definition
smoking
char-grilled meat |
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Term
Name 2 drugs that are CYP2A6 & CYP2B6
Inducers |
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Definition
phenobarbital
dexamethasone |
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Term
Name 4 drugs that are CYP3A4
Inducers |
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Definition
glucocorticoids
rifampin
phenobarbital
St Johns Wort
INHIBITS irreversible:
erythromycin |
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Term
| 2nd Generation H1 rp.drugs |
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Definition
cetrizine..........................most sedating Fexofenadine.................. least sedating
loratidine........................ app stimulant
desloratidine...................active metaolite of loratidine |
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Term
|
Definition
antihrombogenic
analgesic
anti-inflammatory
anti-pyretic |
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Term
Name 5 NSAIDs
that have a slightly
higher affinity for
COX1 |
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Definition
ibuprofen
naproxen
piroxicam
indomethacin
sulindac
ketoralac |
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Term
Name 1 NSAID that
has equal affinity to both
COX1 & COX 2 |
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Definition
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Term
name 1 NSAID that has a greater
affinity to
COX2 |
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Definition
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