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WHS Neuron
neuron function, impulse conduction, synapse
52
Physiology
12th Grade
09/27/2010

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Term
Neuron
Definition
nerve cells that respond to physical or chemical changes in their surroundings
Term
Dendrite
Definition
extensions on neuron that receive the stimuli
Term
axon
Definition
carries nerve impulse away from cell body of neuron
Term
synaptic cleft
Definition
space between axon of 1 neuron and dendrites of another neuron
Term
Schwann Cell
Definition
a neuroglial cell in PNS that wraps itself around axons
Term
myelin
Definition
fatty substance made by schwann cells to insulate parts of the axon from impulses
Term
white, faster, motor neurons
Definition
What are characteristics of myelinated axons?
Term
unipolar, bipolar, multipolar
Definition
What are the structural neuron groups?
Term
sensory, motor, interneurons
Definition
What are the 3 functional neuron groups?
Term
Sensory (afferent) neurons
Definition
What are the neurons that carry info. to the brain?
Term
Motor (efferent) neurons
Definition
What are the neurons that carry info. from brain out to the effectors (muscles and glands)?
Term
Inerneurons
Definition
neurons in brain or spinal cord that link neurons together.
Term
Multiple Sclerosis
Definition
a disease where myelin becomes inflamed due to autoimmune responses and the myelin deteriorates and forms scar tissue. Impulses are impaired.
Term
Astrocyte
Definition
They support neurons structurally support and nutrition for neurons; help create blood brain barrier.
Term
Oligodendrocyte
Definition
provides myelin on several axons in CNS
Term
Microglial cells
Definition
phagocytize bacteria and debris in CNS
Term
Ependymal Cells
Definition
create lining around the brain and ventricles
Term
1. Distal severed axon deteriorates leaving only the neurilemmal sheath of the Schwann cells behind 2. Proximal end of axon sprouts and is guided towards the effector by the neurilemmal sheath. 3. Schwann cells proliferate on new sprouted axon
Definition
What are steps of nerve regeneration?
Term
Tay- Sachs Disease
Definition
excess myelin impairs NS function. Myelin accumulates b/c of a missing lysosomal enzyme. Death occurs by age 4.
Term
Central Nervous System b/c oligodendrocytes don't have neurilemma and they don't proliferate after injury.
Definition
Where is nerve regeneration very unlikely to occur?
Term
Presynaptic Neuron
Definition
Neuron that brings impulse to synapse
Term
Synaptic vessicle
Definition
stores neurotransmitter in synaptic knobs
Term
Saltatory Conduction
Definition
When impulses jump from node to node on myelinated axons, speeding up the impulse.
Term
Calcium, Ca +

A deficiency may cause muscle spasms.
Definition
What ion is required to close Na+ channels?
Term
Anesthetics
Ex. Procaine, Novocaine
Definition
These decrease membrane permeability to Na+ on touch and pain neurons.
Term
Thick and myelinated
Definition
Which nerves are the fastest?
Term
Inhibitory neurotransmitters
Definition
Neurotransmitters that increase permeability to K+ outside neuron and hyperpolarize the membrane
Term
Excitatory Neurotransmitters
Definition
Neurotransmitters that bind to receptors that open Na+ channels, so Na+ diffuses into the neuron
Term
Trigger Zone
Definition
The initial part of the axon where summation of all the stimuli is "summed up" together to determine if threshold is reached.
Term
1. Action potential along axon causes axon to be more permeable to Ca+ and Ca rushes into axon. 2. Ca+ causes synaptic vessicles to migrate to end of knob 3. Vessicles dump neurotransmitter into the cleft.
Definition
What are the steps leading to neurotransmitter release?
Term
enzymes destroy neurotransmitter or reuptake of neurotrans. into vessicles.
Definition
How is the neurotransmitter's effects on the postsynaptic membrane stopped?
Term
Reuptake
Definition
When neurotransmitters are removed from synaptic cleft and put back in syn. vessicles to stop an impulse.
Term
enkephalins, endorphins
Definition
Name two natural painkillers made by the body.
Term
acetylcholine, epinephrine, glutamate, histamine
Definition
Name 3 excitatory neurotransmitters
Term
dopamine, GABA, serotonin
Definition
Name 3 inhibitory neurotransmitters
Term
Acetylcholine
Definition
What's the neurotransmitter that excites skeletal muscles?
Term
Parkinson's
Definition
What disease is caused by a dopamine deficiency?
Term
1. block binding site for neurotransmitter
2. block reuptake of neuro.
3. block synthesis or release of neurotrans.
Definition
List several ways that conduction across a synapse can be interrupted.
Term
The inside is negatively charge compared to the outside. The charge difference is -70 mv
Definition
Describe a resting neuron.
Term
Na+ outside cell membrane; K+ and Cl- are inside cell membrane
Definition
Where are Na+, K+ and Cl- ions in most numerous in the neuron?
Term
Threshold potential
Definition
What't the minimum stimulus needed to reach an action potential?
Term
Neurons are excitable. That means the dendrites become more permeable to Na+ if their stimuli is presnet. If enough Na+ enters to depolarize the membrane to -55mv, an action potential will start
Definition
HOw is threshold reached?
Term
Na+/ K+ pump
Definition
What maintains a polarized membrane in a resting neuron?
Term
Hyperpolarized
Ex. -90 mv
Definition
What is a membrane called that is more negative than the resting potential?
Term
An action potential begins
Definition
What happens when threshold is reached?
Term
Depolarization and Repolarization
Definition
What are the two events in an action potential?
Term
Na+ rushing into the cell membrane
Definition
What depolarizes the neuron?
Term
K+ rushing out of the cell membrane
Definition
What repolarizes the cell membrane?
Term
Impulse
Definition
What is a wave of action potentials called?
Term
If threshold is reached an impulse will travel down the entire axon and all impulses are of the same strength.
Definition
What is the all or none response?
Term
Refractory Period
Definition
the brief time after a nerve impulse where another impulse won't be able to start.
Term
MOre.
Definition
A greater intensity stimulus produces _____ impulses/ second
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