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Week 4 - Monday
Limbic system, hippocampus, amygdala
6
Medical
Professional
05/27/2008
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Term
Hippocampal formation
 Definition

1. Dentate gyrus - 3 layers

2. Hippocampus (Cornu Ammonis) - 3 layers

3. Subiculum 
Term
Dentate gyrus layers
 Definition

Molecular layer

Granule cell layer

Polymorph later (hilus) 
Term
Hippocampus cell layers
 Definition

Stratum radiatum

Pyramidal cell layer

Stratum oriens 
Term
Subdivisions of hippocampus
 Definition
Dentate -> CA3 -> CA2 -> CA1 -> subiculum
Term
Hippocampal pathway
 Definition

1. Entorhinal cortex -> dentate gyrus

//PERFORANT PATH// 

Entorhinal cortex-> hippocampus (small)

2.  dentate gyrus (granule) -> CA3

//MOSSY FIBERS// 

3. CA3 (pyramidal) -> CA1

//SCHAFFER COLLATERALS// 

CA3 (pyramida) -[fornix]-> hippocampus

4.  CA1 -> subiculum

5. subiculum -> entorhinal cortex -> cortical association sites 
Term
Hypothesized sequence of events for temporal lobe epilepsy resulting from axonal reorganization in the hippocampus
 Definition

1. Hilar (polymorph, PM) neurons normally innervate the inner molecular layer of the dentate gyrus

2. Hilar & CA3 neurons are severely depleted in pt w/ temporal lobe epilepsy. Granule cells lost sites of termination

3. Granule cells send zxon collaterals and innervate these vacated synaptic sites. --> hyperexcitability 
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