Term
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Definition
Use:
Leukemias, lymphomas, choriocarcinoma, sarcoma
Abortion, ectopic pregnancy, RA, psoriasis
Mech:
An antimetabolite
Inhibits nucleotide synthesis (thymidine)
Inhibits dihydrofolate reductase
A folic acid analog
Tox:
Myelosuppression (*reversible with leucovorin)
Fatty change to liver
Mucositis
Teratogenic
Contraindications:
Pregnancy |
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Term
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Definition
Use:
Solid tumors, colon cancer, basal cell carcinoma (topical)
Synergy with MTX.
Mech:
An antimetabolite
Inhibits nucleotide synthesis (thymidine)
Inhibits thymidylate synthase
A pyrimidine analog (5F-dUMP), which complexes with folic acid
Tox:
Myelosuppression (*not reversible with leucovorin)
Treat and OD with thymidine
Photosensitivity.
Contraindications: |
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Term
|
Definition
Use:
Leukemias and Lymphomas other than CLL/Hodgkins.
Mech:
An antimetabolite
Inhibits nucleotide synthesis (purine)
A purine analog
Activated by HGPRTase.
Tox:
Bone marrow, GI, liver
Increased toxicity with allopurinol*
Metabolized by xanthine oxidase.
Contraindications: |
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Term
|
Definition
Use:
Mech:
An antimetabolite
Tox:
Contraindications: |
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Term
|
Definition
Use:
Mech:
An antimetabolite
Tox:
Contraindications: |
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Term
| List some common Antimetabolite drugs |
|
Definition
MTX
5-FU
6-MP
6-TG
ara-C
* all hit at S phase to inhibit DNA synthesis |
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Term
|
Definition
| reverses myelosuppression of MTX |
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Term
|
Definition
| Reverses myelosuppression of 5-FU |
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