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Water Balance Lecture
Electrolyte, acid/base balance
46
Anatomy
Undergraduate 2
04/01/2011

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Term
A 150lb male has how much water in his body?
Definition
40l
Term
what percentages make up that 40l of water?
Definition
65% intracellular fluid (inside the cells)
25% extracellular fluid
8% blood/lymph
2% transcellular fluid (cerebrospinal, synovial, pleural, pericardial)
Term
Daily Water output
Definition
averages about ~2500 ml/day
Term
what two sources is water gained from?
Definition
metabolic water and preformed water in food and drinking water.
Term
how much water is in metabolic and preformed water (in food and drink)?
Definition
metabolic: ~200 ml/day
Preformed:~ 700ml/day in food. ~1600ml/day by drinking water
Term
what are the 5 ways your body loses water?
Definition
urine,cutaneous transpiration, expired breath, feces, sweat
Term
out of the 5 ways your body loses water, which one releases the most?
Definition
through urine
Term
Water balance is regulated through complex interactions that begin in the _________ in the thirst center where a number of parameters such as _____,_____.
Definition
hypothalamus; ADH levels and blood osmolality
Term
satiation of thirst requires that the water be absorbed through the lining of the _______and lower the ________ of the blood. This process takes about _____ minutes and would greatly overdo our water intake.
Definition
intestines; osmolality; 30
Term
which is more common, fluid excess or fluid deficiency?
Definition
fluid deficiency
Term
Fluid excess: Volume excess
Definition
when sodium chloride (salt) concentration remain the same and the osmotic pressure remains constant.
Term
Fluid Excess: hypotonic hydration
Definition
The water dilutes the fluid surrounding cells and causes them to swell. This may result in metabolic disorders, nausea, vomiting, muscular cramps, and, in extreme cases, death.
Term
hypotonic hydration sometimes occurs when...
Definition
you lose large volumes of water and salt as urine or sweat and you replace the loss with water alone.
Term
fluid sequestration
Definition
occurs when excess fluid accumulates in a particular part of the body
Term
Edema: one of the causes of? and what 3 things does this often involve?
Definition
one of the causes of fluid sequestration. often involves increased capillary filtration, reduced capillary reabsorption, obstructed lymphatic drainage.
Term
How much sodium is needed per day and how much does the typical person get?
Definition
.5 g a day needed. but most people recieve about 10-15 g a day.
Term
What are sodium levels regulated by?
Definition
aldosterone secretion and ADH levels
Term
what is the most abundant cation in the intracellular fluid?
Definition
potassium
Term
what is responsible for regulating potassium?
Definition
strongly tied to sodium regulation and aldosterone plays a major role.
Term
How does regulating potassium work?
Definition
1. when potassium levels start to get too high, aldosterone secretion is turned on.
2.aldosterone secretion triggers K+ secretion in the kidney tubules. ( telling the kidneys to remove more potassium)
Term
Hyperkalemia
Definition
high potassium levels in the blood.
Term
what can happen to cells if there is excess potassium in the ECF? (hyperkalemia)
Definition
it causes potassium ions to leak into the cells and depolarize them. can make muscle and nerve cells stop working and can cause cardiac arrest.
Term
where can excess potassium occur?
Definition
sometimes occurs from blood transfusions of stored blood because the potassium tends to leak out of the RB cells and into the plasma during storage.
Term
Chloride ion concentrations follow _______ and ______ levels.
Definition
Na and K
Term
Calcium homeostasis involves ______ and ___________ hormone secretion.
Definition
calcitonin and parathyroid
Term
__________ levels play a role in ATP synthesis and degradation, as well as forming main buffers in the body.
Definition
phosphate (HPO4 and H2PO4)
Term
Ph is the measure of...
Definition
H+ ion concentration
Term
what PH level is neutral?
Definition
7
Term
the Ph scale is ________ meaning that the last value is either 10x more or less concentrated.
Definition
logarithmic.
Term
Basic means _____ H+ and is ___ on the scale
Definition
less; higher
Term
H+ ion concentration and the PH scale relate _________.
Definition
inversely
Term
Bases (OH-) and H+ ions react to make__
Definition
water.
Term
Buffers
Definition
compounds that resist changes in PH by either absorbing H+ or OH- ions
Term
our tissue fluids are slightly basic with a PH of ____
Definition
7.4
Term
what does the buffer system do?
Definition
keep our tissues at a slightly basic pH
Term
Bicarbonate ion system equation
Definition
Co2 + H20 <--> H2CO3 <---> HCO3 + H+
Term
the bicarbonate buffer system optimally keeps a pH of
Definition
6.1
Term
Phosphate buffer system
Definition
H2PO4 <-----> HpO4 + H+
Term
the phosphate buffer system optimally keeps a ph of
Definition
6.8
Term
protien buffer system
Definition
COOH ----> COO + H+
NH2 + H+ <---> NH3
Term
The respiratory system plays a major role in PH control by using the
Definition
reciprocal of the bicarbonate buffer system
(the bicarbonate system backwards)
Term
the kidneys secrete ____ ions into the _____ convoluted tubules and collecting ducts
Definition
H+ and distal
Term
acidosis
Definition
excess acid in the body systems
Term
respiratory symptom of acidosis
metabolic symptom of acidosis
Definition
hypoventilation;
excess organic acid production and diabetes
Term
alkalosis
Definition
body fluids have excess base.
Term
respiratory and metabolic symptoms of alkalosis
Definition
resp: hyperventilation
metabolic: chronic vomiting
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