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Visual Pathway
Neuroanatomy Visual Pathway
162
Anatomy
Graduate
03/14/2012

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Term
aside from vision, what functions does information received from the retinas intitate
Definition
1. adjusting the size of the pupil; 2. regulation of circadian rhythm; 3. directing movements of the head
Term
where do axons of ganglion cells in the retina project
Definition
through the optic disk at the back of the retina
Term
what are the axons that project from the retina through the optic disk called
Definition
optic nerve
Term
where does the optic nerve go immediately after leaving optic disk
Definition
optic chiasm
Term
what do optic nerve axons do at the optic chiasm
Definition
~60% of axons cross to the other side. Remaining 40% continue ipsilaterally toward the thalamus
Term
what do we call these visual axons once they've passed the chiasm
Definition
optic tracts
Term
does an optic tract contain axons from one or both eyes
Definition
both
Term
why is the crossing of optic nerve fibers in the chiasm important/ what functional things result?
Definition
for binocular vision and stereopsis
Term
what is stereopsis
Definition
depth perception
Term
where do fibers from the optic tracts project to (general areas of the brain?)
Definition
to 4 major structures within the midbrain and diencephalon
Term
what are the 4 major structures within the midbrain and diencephalon that fibers from the axon tracts project to
Definition
lateral geniculate nucleus of thalamus; hypothalamus; pretectum; superior colliculus
Term
where do neurons in the lateral geniculate nucleus of the thalamus send their axons to
Definition
cortex
Term
what do neurons in the lateral geniculate nucleus of the thalamus go through to get to the cortex
Definition
optic radiations
Term
in what part of the cortex do optic radiations from the lateral geniculate nucleus of the thalamus terminate
Definition
primary visual cortex/striate cortex
Term
where is the primary visual cortex
Definition
occipital lobe
Term
what is the Brodmann's area of the primary visual cortex
Definition
17
Term
what is another term for the visual primary sensory cortex
Definition
V1
Term
what are 2 terms for the pathway between the lateral geniculate nucleus of the thalamus and the primary visual cortex
Definition
geniculostriate pathway or primary visual pathway
Term
the information that they geniculostriate pathway conveys is essential for what?
Definition
visual perception
Term
what does the primary visual cortex project to
Definition
temporal, parietal, and frontal lobes
Term
what are extrastriate visual projections
Definition
projections from V1
Term
what are the 2 extrastriate pathways
Definition
ventral pathway, dorsal pathway
Term
where does the ventral pathway project?
Definition
to the temporal lobe
Term
what is the ventral pathway responsible for
Definition
object recognition (shape, color, texture)
Term
where does the dorsal pathway project
Definition
parietal lobe
Term
what is the dorsal pathway responsible for
Definition
analysis of movement /spatial vision
Term
where in the frontal lobe does visual information project to
Definition
frontal eye fields
Term
what is the brodmann's area of the frontal eye fields
Definition
8
Term
where in the brain do we have object recognition
Definition
temporal lobe
Term
what part of the hypothalamus do axons from the optic tract project to?
Definition
suprachiasmatic nucleus
Term
what is the name of the pathway of axons from the retina to the suprachiasmatic nucleus the hypothalamus
Definition
retino-hypothalamic pathway
Term
what does the retino-hypothalamic pathway influence
Definition
circadian rhythm and visceral autonomic functions
Term
why is it that you can feel viscerally ill from seeing smoething?
Definition
retino-hypothalamic pathway carries the visual information and influences visceral autonomic functions
Term
what are axons that project to the pretectum from the retina responsible for
Definition
pupillary light reflex
Term
what is the pupillar light reflex
Definition
light stimulates both pupils to constrict
Term
where do neurons from the pretectum project to
Definition
BOTH edinger-westphal nuclei in the midbrain
Term
where do preganglionic parasympathetic neurons in the edinger-westphal nucleus project
Definition
to the ciliary ganglion
Term
what do preganglionic parasympathetic neurons go through from the edinger-westphal nucleus to get to the ciliary ganglion
Definition
CN III
Term
where do postganglionic parasympathetic neurons from the edinger-westphal nucleus go
Definition
to the sphincter pupillary muscle
Term
what do the postganglionic parasympathetics from the edinger-westphal nucleus do after they have synapsed on the preganglionic parasympathetics in the ciliary ganglion
Definition
cause constriction of the pupil
Term
what is the path of light coming into one eye
Definition
light comes in and projects to the retina. Goes to pretectum. Goes to edinger-westphal nuclei. Goes to ciliary ganglion via CN III, synapses, postganglionic causes constriction of the pupil
Term
how should pupils respond if one eye is stimulated by light
Definition
both pupils should constrict identically
Term
what is the direct response of light stimulation
Definition
constriction in the stimulated eye
Term
what is consensual response
Definition
constriction in the unstimulated eye
Term
what does a direct response to the left eye without a consensual response in the right eye indicative of
Definition
possible damage to the brainstem: Edinger-westphal nucleus or CN III
Term
why would you test pupillary response in someone who's unconscious
Definition
gives you an idea of what's happening in the midbrain
Term
where is the superior colliculus
Definition
midbrain
Term
what do projections from the superior colliculus influence/coordinate
Definition
movements of the head and eyes - how we follow visual information around
Term
what are the 2 parts of the retina
Definition
nasal retina, temporal retina
Term
what part of the visual field is seen by the nasal retina
Definition
lateral
Term
what part of the visual field is seen by the temporal retina
Definition
medial
Term
where do objects in periphery project to
Definition
nasal retinas
Term
where do objects in front project to
Definition
temporal retina
Term
which axons from the retina will cross in the chiasm
Definition
ganglion cells in the nasal portion of the retina (the ones that see the periphery)
Term
which axons from the retina will not cross in the retina but will remain on the same side
Definition
ganglion cells in the temporal portion of the retina (the ones that see right in front)
Term
if you see an object directly in front of your left eye, what is its path?
Definition
falls on the nasal retina of the left eye and the temporal retina of the right eye. Axons from both project through the right optic tract
Term
on which retinal portions would an image to your right fall, and on which optic tract will it travel?
Definition
right nasal, left temporal. Left optic tract
Term
through which optic tract is information from the left visual field carried
Definition
right optic tract
Term
to which side of the primary visual cortex does the left visual field project
Definition
right
Term
through which optic tract is information from the right visual field carried
Definition
left optic tract
Term
to which side of the primary visual cortex does the right visual field project
Definition
left
Term
what are anopsias
Definition
large visual field deficits
Term
what are scotomas
Definition
smaller visual field deficits
Term
what is a quadrantanopia
Definition
lose a quarter of a visual field
Term
what is the result of damage to the retina or optic nerve
Definition
loss of vision ipsilaterally
Term
what is the result of damage to the optic chiasm
Definition
affects fibers crossing from both nasal retinas but doesn't affect uncrossed fibers from the temporal retinas = lose periphery of visual field
Term
if you lose your optic nerve going to your right eye, what will you see
Definition
see everything from left eye
Term
if you lose your optic chiasm, what will you see
Definition
center: tunnel vision
Term
what major gland sits right underneath the optic chiasm?
Definition
pituitary
Term
what is the result of damage to the right optic tract?
Definition
loss of sight in the left visual field: loss of nasal visual field of right eye and loss of temporal visual field of left eye
Term
what is the result of damage to part of optic radiations
Definition
partial anopsias
Term
what is meyer's loop
Definition
portion of optic radiation that projects into the temporal lobe . Often damaged by strokes/tumors
Term
what is the exact path of meyer's loop
Definition
projections from the lateral geniculate to the visual cortex that swing laterally into the temporal lobe
Term
what part of the visual field is carried by the superior optic radiations
Definition
inferior visual field
Term
what part of the visual field is carried by the inferior optic radiations
Definition
superior visual field
Term
what is the result of damage to the primary visual cortex
Definition
loss of a large vision of R or L visual field with sparing of foveal vision
Term
how many extraocular muscles are there
Definition
6
Term
what movements are useful models for studying motor contorl
Definition
eye movements
Term
what have neuroscientists studied to learn about the cerebellum, basal ganglia, and vestibular systems
Definition
eye movements
Term
what is essential for visual perceptin
Definition
eye movements
Term
what is the region of highest visual acuity
Definition
fovea
Term
what is the fovea
Definition
a small circular region on the retina that is densely packed with cone photoreceptors
Term
what is the role of our extraocular muscles
Definition
direct visual information to the fovea
Term
what is foveation
Definition
direction of visual information to the fovea
Term
what is a secondary responsibility of extraocular muscles
Definition
compensate for disturbances that cause the fovea to be displaced from a target already being attended to
Term
who is alfred yarbus
Definition
russian physiologist who studied eye movements
Term
what are saccades
Definition
the thin, straight lines/shifts of ballistic movements that our eyes constantly make
Term
purpose of saccades
Definition
align fovea with area of interest
Term
in Queen Neffertiti bust, what are the denser spots of eye movements
Definition
points of fixation where the subjects paused to perceive visual information
Term
how long do saccades last
Definition
1/10th of a millisecond
Term
does visual perception occur during a sacade
Definition
no
Term
how is vision an active process
Definition
eye movements typically shift the view several times/second
Term
what do eye movements allow us to do
Definition
scan the visual field, pausing to focus attention on the portions of the scene that convey the most significant information
Term
what happens if youparalyze extra ocular muscles
Definition
image is projected to exactly the same parts of the retina. The stabilized retinal image disappears. You can't see
Term
what are the 3 antagonistic pairs of eye muscles that control eye movements
Definition
lateral/medial rectus; superior/inferior rectus; superior/inferior obliques
Term
what are the 3 axes of eye movements
Definition
horizontal, vertical, torsional
Term
what are the 2 options for horizontal eye movement
Definition
adduction/abduction
Term
what are the 2 options for vertical eye movement
Definition
elevation/depression
Term
what are the 2 options for torsional eye movement
Definition
intorsion/extorsion
Term
what is intorsion
Definition
bring the top of the eye toward the nose
Term
what is extorsion
Definition
bring the top of the eye away from the nose
Term
what muscles control horizontal movements of the eye
Definition
medial and lateral rectus
Term
what muscles cause elevation of the eye
Definition
superior rectus and inferior oblique
Term
what muscles cause depression of the eye
Definition
inferior rectus and superior oblique
Term
what 3 cranial nerves innervate extraocular muscles
Definition
abducens, trochlear, oculomotor
Term
where in the brainstem is the abducens nucleus located
Definition
pons
Term
what does the abducens innervate
Definition
lateral rectus
Term
where does the trochlear nerve exit the brainstem
Definition
dorsal side
Term
what does the trochlear nerve do after exiting dorsal side of brainstem
Definition
crosses to the midline
Term
what muscle does the trochlear nerve innervate
Definition
superior oblique
Term
does the trochlear nerve innervate the ipsilateral or contralateral superior oblique
Definition
contralateral
Term
where in the brainstem does the oculomotor nerve exit
Definition
midbrain
Term
what does the oculomotor nerve innervate
Definition
all extraocular muscles except superior oblique and lateral rectus
Term
what do oculomotor parasympathetics do
Definition
pupillary constriction
Term
what provides innervation to the extraocular muscles along with the oculomotor nucleus 
Definition
separate groups of lower motor neurons
Term
what are the 3 basic types of eye movements
Definition
saccades, smooth pursuit, vestibulo-ocular movements
Term
what are saccades
Definition
rapid, ballistic eye movements that abruptly change the point of fixation
Term
what is the range in amplitude of saccades
Definition
from small (reading) to large (scanning a room)
Term
are saccades voluntary or involuntary?
Definition
voluntary, but they occur reflexively/unconsciously. You can control them, but they happen so fast that we don't think about them.
Term
what are rapid eye movements
Definition
saccades that occur in our sleep
Term
when a target moves, how long does it take for eye movement to bgein
Definition
200ms
Term
what happens during the 200ms delay between movement of atarget and movement of the eye
Definition
the new position of the target with respect to the fovea is computed (how far the eye will have to move.) a motor command activates the extraocular muscles to move the eye the correct distance/direction
Term
can the saccade-generating system respond to changes in target position during the course of a saccade?
Definition
no
Term
what must happen if the target moves during a saccade
Definition
after the original saccade, another saccade must be generated to correct the error
Term
what do vestibulo-ocular movements/reflexes do
Definition
stabilize the eyes relative to head movements = compensate for head movements = prevent visual images from slipping on the surface of the retina as head position varies
Term
when do you use your Vestibulo-ocular reflex
Definition
when you look at a stationary object and move your head without removing your gaze
Term
what movements do eyes make to compensate for head movement using VOR
Definition
eyes move the same distance as the head but in the opposite direction
Term
what is the ultimate purpose of the VOR
Definition
keep the visual image on the same place of the retina
Term
what is it that directs the eyes to move in the direction opposite head movements in VOR
Definition
sensory information from the semicircular canals
Term
what 2 separate issues are involved in moving the eyes to fixate on a new target
Definition
controllowing the amplitude (how far) and controlling the direction (which way)
Term
what tells the eye how far to move (amplitude) in a saccade to fix on a target
Definition
amplitude is encoded by the duration of neuronal activity/action potentials in the LMNs of CN nuclei III, IV, VI
Term
what determines the direction of saccadic movements
Definition
which eye muscles are activated
Term
what controls which eye muscles are activated
Definition
gaze centers
Term
where are the 2 gaze centers
Definition
reticular formation
Term
what are the 2 gaze centers
Definition
paramedian pontine reticular formation, rostral interstitial nucleus
Term
what is the paramedian pontine reticular formation responsible for
Definition
horizontal eye movements
Term
what is the rostral interstitial nucleus responsible for
Definition
vertical gaze
Term
where is the paramedian pontine reticular formation
Definition
in the reticular formation of the pons, near the midline
Term
what does separate activation of the gaze centers result in
Definition
movement along a single axis: either vertical or horizontal
Term
what does activation of the gaze centers in concert result in
Definition
oblique movements, specified by relative contributions from each gaze center
Term
which 2 cranial nerves does the paramedian pontine reticular formation work with to make horiztonal eye movements
Definition
abducens and oculomotor
Term
does the paramedian pontine reticular formation innervate the ipsilateral or contralateral abducens nucleus
Definition
ipsilateral
Term
what are the 2 types of neurons in the abducens nucleus
Definition
lower motor neurons, internuclear neurons
Term
what do lower motor neurons in the abducens nucleus do
Definition
innervate the lateral rectus muscle ipsilaterally
Term
what do internuclear neurons in the abducens nucleus do
Definition
send axons across the midline to the contralateral oculomotor nucleus
Term
through what tract does the internuclear neuron of the abducens send axons to the oculomotor nucleus
Definition
medial longitudinal fasciculus
Term
what is the medial longitudinal fasciculs
Definition
small axon that goes between cranial neurons to coordinate things
Term
How does the paramedian pontine reticular formation work in conjunction with the abducens and oculomotor nuclei to generate a horizontal saccade to the right
Definition
1. Neurons in the right PPRF innervate cells in the right abducens nucleus. 2a. LMNs in the R abducens nucleus innervate the R lateral rectus. 2b. Internuclear neurons travel from the R abducens nucleus to the L oculomotor nucleus via the medial longitudinal fasciculus. 3. the L oculomotor nucleus contains LMNs that innervate the L medial rectus muscle
Term
what is the result of activation of the PPRF on the right side of the brainstem
Definition
horizontal movements of both eyes to the right
Term
how does activation of the R PPRF affect muscles that oppose eye movements toward the right
Definition
activation of the PPRF on the right results in a reduction of activity of LMNs whose muscles oppose eye movements to the right via inhibitory neurons
Term
How do visual stimuli activate the appropriate gaze center? In other words, how does visual sensory information concernint the location of a visual target initiate accurate saccadic eye movements?
Definition
projections to the gaze center from the frontal eye fields and superior colliculus
Term
what 2 important structures project to the gaze centers?
Definition
frontal eye fields, superior colliculus
Term
what do both the frontal eye fields and superior colliculus contain?
Definition
cells that respond to visual stimuli
Term
what do the cells that respond to visual stimuli in the frontal eye fields and superior colliculus do immediately prior to saccades?
Definition
discharge
Term
what does the frontal eye field project to
Definition
superior colliculus AND contralateral PPRF
Term
what does the superiro colliculus project to
Definition
contralateral PPRF
Term
how can the frontal eye field control eye movements independent of the superior colliculus
Definition
frontal eye field projects to superior colliculus as well as to contralateral PPRF
Term
how are the frontal eye field and superior colliculus redundant
Definition
they both project to the PPRF control for saccades
Term
if you injure the frontal eye field on the R side of your brain, what will happen
Definition
you will have diffuclty making eye movements towards your L side
Term
what does injury to a frontal eye field result in
Definition
inability to make saccades to contralateral side
Term
what does injury to superior colliculus result in
Definition
delays in the accuracy and velocity of saccades
Term
if you lose either a frontal eye field or a superior colliculus, what will happen
Definition
over time, one will compensate for the loss of the other
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