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Details

Viruses
Creighton University School of Medicine
11
Medical
Professional
01/17/2013

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Cards

Term
dsDNA (nucleus)
Definition
Herpes = envelope/icosahedral
Adenovirus = no envelope/icosahedral
Papilloma = no envelope/icosahedral
Polyomavirus = no envelope/icosahedral
Term
dsDNA (cytoplasm)
Definition
Poxvirus = unique complex capsid
Term
ssDNA
(some viruses packaged with a + strand while others packaged with a – strand)
Definition
Parvovirus = no envelope/icosahedral
(causes Fifths disease w/ red cheeks)
Term
+ RNA coding for one-genome-size RNA
Definition
Picornavirus (HAV) = no envelope/ icosahedral
Flavivirus =
Term
+ RNA coding for one or more subgenomic mRNAs
Definition
Coronavirus = envelop/helical
Togavirus =
Term
Diploid + ssRNA genome
Definition
retroviruses (HIV) - envelope, icosahedral
Term
Non-segmented – RNA viruses
Definition
Paramyxoviruses = envelope/ helical (e.g. RSV, measles, mumps)
Rhabdovirus (rabies) = envelope/ helical
Filovirus (ebola) = envelope/helical
Term
Segmented – RNA viruses
(mixing of segments in host cell can make new virions -> pandemics)
Definition
Orthomyxoviruses (influenza A)
- envelope/helical segments
- M2 = ion channel protein
- Acidification of virion via M2 allowing H+ inside -> conformation change of M proteins -> dissociation from NP proteins -> viral genome leaves endosome for cytoplasm

Bunyaviruses
- envelope/helical segments
- arthropod-borne
- encephalitis, hemorrhagic fevers, hantavirus pulmonary syndrome
- NO MATRIX (M) PROTEIN
Term
dsRNA viruses
Definition
Reovirus

Rotavirus
- No envelope/icosahedral
- 40-60% of diarrhea in children <2 years of age
- Most significant cause of severe gastroenteritis in young children (lethal in areas of malnutrition)
Term
Relaxed circular partially duplexed DNA
Definition
Hepadnaviruses (HBV) -enveloped, icosahedral
Term
Ambisense RNA viruses
Definition
Arenavirus
- Envelope/2 ssRNA circles
- Lymphocytic choriomeningitis (LCM)
- Endemic to tropics of Africa and South America
- Most asymptomatic and cause persistent infections
- Examples: LCM, Lassa
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