"Fuck The Rna Positive Cali and Coronavirus"

Flaviviridae (env. icos.)

Togaviridae ('' '')

Retroviridae (" ")

Picornaviridae (naked icos.)

Calicivirus (naked icos.)

Astrovirus (naked icos.)

Coronaviridae (env. heli)

Paramyxoviridae

Filoviridae

Orthomyxoviridae

Rhabdoviridae

Arenaviridae

Bunyaviridae

Orthomyxoviridae

Retroviridae

"BOAR"

Bunyaviruses :3 segments

Orthomyxovirus : 8

Arenavirus : 2

Reovirus : 10 or 11

"PAP"

Parvovirus

Adenovirus

Papovavirus

DR. P-olitically C-orrect

Deltavirus

Reovirus

Picornavirus

Calcivirus

HHAPPPy

Herpesviridae

Hepadnaviridae

Adenoviridae

Papovaviridae

Parvoviridae

Poxviridae

TORCHeS

Toxoplasmosis

Other infections

Rubella

Cytomegalovirus

Herpes, HIV

Syphilis

Herpes Virus

Hepadnavirus

non-lytic release from host cell

lipoprotein envelope from host nuclear membrane

Orthomyxovirus

Bio: ss (-)RNA, segmented (8), lipid envelope, helical shape, replicates in nucleus

Virulence: HA and NA held by M-protein

Path: Flu, secondary bacterial pneumonia, Reye's syndrome

Treat: vaccine (egg grown); amantadine & rimantidine to prevent type-A uncoating; sanamavir + oseltamivir are NA inhibitors

Paramyxovirus

Bio: ss (-) RNA, unsegmented, lipid envelope, helical symmetry, cytoplasm replication

Virul: glycoprotein with combined HA & NA; F-protein (fusion) causing synctial cells

Path: Upper resp. tract infection; viral pneumonia; Croup (child barking and larynx swelling); bronchiolitis in kids

Treat: supportive

Paramyxovirus

Bio: ss (-) RNA, unsegmented, lipid envelope, helical symmetry, cytoplasm replication

Virul: No HA or NA; F-protein

Path: most common pneumonia in infants; acute otitis media in children

Treat: Palivizumab (monoclonal antibody prophylaxis); Respigam (gamma globulin); (passive immunity) + Ribavirin

Paramyxovirus

Bio: ss (-) RNA, unsegmented, lipid envelope, helical symmetry, cytoplasm replication

Virul: glycoproteins with HA & NA; F-protein

Path: Parotid swelling; testicular inflammation; meningitis; encephalitis

Treat: MMR vaccine (measles, mumps - rubella)

Paramyxovirus

Bio: ss (-) RNA, unsegmented, lipid envelope, helical symmetry, cytoplasm replication

Virul: HA but no NA; F-protein

Path: Prodrome (high fever, hacking cough, conjunctivitis); Koplik's spots; Rash (head to toe); Subacute Sclerosing Panencephalitis (SSPE) slow form of encephalitis over years

Treat: MMR vaccine

Herpes simplex virus - 1

(HSV-1)

Bio: ds linear DNA; enveloped; icosahedral sym

Transmission: mucous membrane contact; STD

Path: Gingivostomatitis; reactivation via stress; Herpetic keratitis (corneal blindness); encephalitis

Treat: Acyclovir; trifluridine (topical); Famciclovir

Diag: Tzanck prep for syncytial cells; viral culture; PRC; serology; direct flourescent antibodies (DFA)

Herpes simplex virus-2

(HSV-2)

Bio: DS linear DNA; enveloped; icosahedral sym

Path: Genital herpes; reactiviation; neonatal herpes (ToRCHeS)

Treat: Acyclovir; condom use

Diag: Tzanck prep, viral culture, PCR, DFA

Varicella-zoster virus

(VSV)

Bio: DS Linear DNA; enveloped; icosahedral

Transmiss: Aerosolized resp. secretions; contact with ruptured vesicles; Zoster- reactivation form dorsal root ganglia

Path: 2 week incubate Varicella (chickenpox), crop of rash (dew drop rose petal), fever, headache; Zoster (shingles) vesicles isolated to dermatome, blindness if CN5

Treat: acyclovir, zoster immune globulin

Diag: tzank prep, examining rash

Cytomegalovirus

(CMV)

Bio: DS linear DNA, evenlope, icosahedral

Transmiss: milk, saliva, urine, tears; day-care centers; STD; ToRCHeS

Path: asymptomatic infection (latent); ToRCHeS; CMV mononucleosis; reactivation in immunocomp.: retinitis (AIDs); Pneumonia (bone marrow trans); esophagitis

Treat: for immune comp Foscamet;Ganciclovir;cidofovir; fomivirsen. Support for regs, DO NOT GIVE AMPICILLIN

Epstein-Barr virus

(EBV)

Bio: DS linear DNA; envelop; icosahedral

Trans: "kissing bug"

Path:infectious mononucleosis, fever, sore throat, lethargy, enlarged lymph nodes and spleen; Burkitt's B-cell lymphoma

Treat: If person is thought to have strep. and given ampicillin, patient will get rash

Human Herpesvirus 6

(HHV-6)

Trans: saliva

Path: Roseola (exanthem subitum) high fever followed by rash on trunk

Human Herpesvirus 8

(HHV-8)

Trans: STD via homosexual men

Path: Kaposi's sarcoma

vertical transmission, mother to child

TOxoplasmosis

Others

Rubella

Cytomegalovirus

HErpes, HIV

Syphilis

Hepatitis A

(HAV)

Bio: Picoma virus; SS (+) RNA; Naked; Icosahedral; Fecal-oral

Path: Acute viral hepatitis, fever, jaundice

Treat: new HAV vaccine, pooled immune serum

Serology: Anti-HAV IgM (active disease); Anti-HAV IgG (old, non-active disease)

Hepatitis B

(HBV)

Bio: Hepadna virus; DS circular DNA; enveloped; icos; "Dane particle" (intact virus)

Trans: blood trans; needle stick; sex

Path: acute viral hep; fulminant (acute + rapid destruction); chronic hep; co-infect w/ HDV; liver cancer

Treat: vaccine, interferon-alpha; nucleoside analogs

Sero: HBsAG (diseased), Anti-HBsAG (immune); IgM anti-HBcAG (new inf.); IgG anti-HBcAG (old inf.); HBeAG (high infect.); Anti-HBeAg (low infect.)

Hepatitis C

(HCV)

Bio: Flavivirus; SS (+) RNA; env. icos

Trans: blood trans; needle stick; sex

Path: most common cause of chronic hep; increased risk of primary hepatocellular carcinoma; genotype 1 is more US common; leading cause of liver transplants

Treat: interferon + ribavirin

Hepatitis D

(HDV)

Bio: incomplete RNA virus requires HBV env; helical

Trans: blood trans; needle stick; sex

Path: coinfection with HBV + HDV (anti-HBV cure); superinfection (chronic HBV with HDV, patient cant prod. anti-HBV)

Hepatitis E

(HEV)

Bio: Hepevirus; ss (+)RNA; naked

Trans: fecal-oral

Path: acute viral hep, similar to HAV