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Definition
| Movement of drug molecules from site of administration into sytemic circulation. |
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Definition
| Movement of drug from the sytemic circulation into tissues. |
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| Effects drugs have while in the body. |
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Definition
| Ideal range of drug concentrations within the body. |
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| A dose designed to raise the drugs concentration to therapeutic range in a short amount of time. |
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| Amount of drug given to equal the amount lost via elimination. |
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Definition
| Random movement of drug molecules from an area of high concentration to an area of low concentration or down the concentration gradient. |
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Definition
Passive transport across cell membranes that involves a carrier molecule within membrane.
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| Carrier molecules within the membrane move the drug, and require energy in order to reset the carrier after transport. |
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Definition
| A molecule having a permanent electric dipole moment. |
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Definition
| Protein within cell membrane that changes when drug mole combines with it. "AKA" Carrier Protein. |
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Definition
| Graduated difference in concentration of solute per unit distance through a solution. |
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Definition
The max speed at which a transport molecule can work.
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Definition
| Absorption, Distribution, Metabolize, Elimination. |
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Definition
The proportion of a drug dose that enters the systemic circulation.
(i.e. IV drugs have 100% bioavailability) |
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| The time from administration till absorption is complete. |
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| The pH at which a drugs molecules will be in equilibrium between the ionized and non-ionized forms. |
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Definition
| Injection of fluid into blood vessel in order to reach an organ or tissues. |
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| Tiny holes between cells of most capillaries. |
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Definition
| Capillaries in some tissues have no holes. These are called tight junction. |
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| Process of drug movement from one tissue→back into the blood→and then to the second tissue. |
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Definition
| Drugs having a substantial concentration still within the circulation, and act as a reservoir. |
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| Principle protein within plasma-made by the liver. |
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Definition
| Class of compounds used for hypnotic or sedative effects. |
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Definition
| The value used to describe how much of body a drug is distributed to. |
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Definition
| How the body changes drugs. Liver is the main organ for this. |
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Definition
| Rate at which a volume of blood is cleared of drug. Eliminated. |
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| A protein within the cell membrane that combines with the drug. |
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Definition
| Produces an effect in a cell. |
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Definition
| Will block the receptor- the agonist can't attach, so the agonist has no effect. |
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Definition
| Compare to a dimmer switch-may be somewhere in between. |
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Definition
| Compounds used as drugs that physically combine with ion or other compounds in the environment to produce their effects. |
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Term
| Autonomic Nervous System- |
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Definition
Sympathetic N.S.
Parasympathetic N.S. |
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Definition
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| Are in the heart-Increase rate-Increase strength of contraction. |
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Definition
| Are in the smooth muscle surrounding vessels in muscles/terminal bronchioles in the lungs. |
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Definition
| In smooth muscle surrounding vessels in skin and GI tract. |
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