Term
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Definition
Leukocytosis
Neutrophilia
Monocytosis
Eosinopenia
Lymphopenia
See with steroid use |
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Term
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Definition
Produced in bone marrow
Involved in inflammatory reactions
Neutrophils most numerous
first line of defense
All function in tissues |
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Term
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Definition
Myeloblast
Progranulocyte
Myelocyte
Metamyelocyte
Band
Mature seg |
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Term
| Leukocyte Production - Time |
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Definition
Myeloblast myelocyte
takes 3-4 days
Myelocyte seg
matures in 3-4 days
Then stored 5-6 days
Whole process takes 10-11 days |
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Term
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Definition
Circulating pool- 9 -12 hours
where collect blood
Marginal pool- along caps
Equal amounts of segs
Excitement s segs in circulating pool
Storage pool - in marrow
30x segs in other pools
5 day supply in the dog
Function or die in tissues
Six hour half-life
Feedback mechanism
leukopoietin from cell death |
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Term
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Definition
Usually due to neutrophilia
Infections
Rapidly growing neoplasm
Trauma
Stress
Anemia/hemolysis |
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Term
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Definition
Depression
Degeneration
Depletion
Destruction |
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Term
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Definition
Marrow loses ability to make segs in response to peripheral demand
segs, no bands
can recover
seen in various infections |
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Term
| Leukopenia - Degeneration |
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Definition
Deficiency of marrow
Segs unable to mature
Large # immature bands
Nutritional deficiency
May recover if problem corrected |
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Term
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Definition
High peripheral demand
Storage pool exhausted
Degenerative left shift results
Improves in time if it lives
In overwhelming infections
i.e. pyometra |
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Term
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Definition
Blood forming cells destroyed
Decrease in all cell types
Due to chemical/physical agents
estrogen
chloramphenicol
radiation |
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Term
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Definition
Viral infections
Overwhelming bacterial infect
Gram negative endotoxemia
Poor nutritional state
Physical agents- i.e.radiation
Chemical agents- i.e. drugs |
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Term
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Definition
Granules stain neutral
may be light pink
Nucleus twisted, lobulated
May see filaments between lobes
Chromatin clumpy
Pale cytoplasm
AKA segs, polys, PMNs
Analogous to heterophils
redder granules in other species
12-15 microns in diameter
Active phagocytes |
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Term
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Definition
Hemocytometer
Manual counting
2 counting chambers
To count cells
primary squares
Multiplication factors
Use low light |
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Term
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Definition
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Term
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Definition
Neutrophil
•Twisted nucleus
•Clumpy chromatin
•Pale granules
–often invisible
–see in some
•Most frequent granulocyte |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Band neutrophil
•No nuclear indentations >1/3 width
–often U-shaped
•Less clumpy chromatin
•Slight cytoplasmic basophilia
•Normal immature cell
–1-2% of wbc’s |
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Term
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Definition
Toxic seg
•Usually toxemia present
•Basophilic cytoplasm
•Vacuoles
•Dark blue granules (Dohle bodies) |
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Term
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Definition
Eosinophil
•Round, red granules
–vary w/ species
•Nucleus less twisted
•May not see any
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Term
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Definition
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Term
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Definition
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Term
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Definition
Basophil
•Rarely seen
•Blue granules
–species variation
•pale to dark blue
–may obscure nucleus
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Term
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Definition
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Term
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Definition
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Term
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Definition
Lymphocyte
•Small, medium, large
•Round cell
•Round nucleus
–may have indentation
•Thin rim of blue cytoplasm
•Clumpy chromatin |
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Term
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Definition
Activated lymphs
•Deep blue cytoplasm
•Normal cells
•Due to antigenic stimulation
•Often see post vaccination
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Definition
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Definition
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Term
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Definition
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Term
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Definition
Metarubricyte
•Nucleated rbc
•Ý in regenerative anemias
•Confused with lymphocytes
•Counted as wbcs
–must correct leukocyte count
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Term
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Definition
Monocyte
•Largest leukocyte
•Variably shaped nucleus
–round, indented, twisted
•Pale gray blue cytoplasm
–often see vacuoles |
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Definition
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Definition
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Definition
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Definition
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Definition
Skipocytes
•All leukcocytes have a cytoplasm & nucleus
•Distorted cells
•Cell fragments
•Free nuclei
•Trash- dirty slide |
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Term
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Definition
Thrombocytes
•AKA platelets
•No nucleus
–cytoplasmic fragments
–may see granules
•Still considered a cell
•Usually small
–if large are immature |
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