Term
| What are the three possible mechanisms for vasculitis? |
|
Definition
ANCA
immune complex
T-cell |
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Term
| What must you do to diagnois a vasculitis disease prior to treating with corticosteriods? |
|
Definition
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Term
| What are the two vasculitis studied that effect larger vessels? |
|
Definition
Giant Cell (temporal) Arteritis
Takayasus Arteritis |
|
|
Term
| Which of the large vessel vasculitis is more common in older women? |
|
Definition
|
|
Term
| What is the most common adult vasculitis? |
|
Definition
| giant cell (temporal) arteritis |
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|
Term
| What is the pathologic process of giant cell arteritis? |
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Definition
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Term
| In giant cell arteritis what do you need to specifically biopsy in order to make a diagnosis? |
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Definition
|
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Term
| What is the pathalogic progression of the lesions in giant cell arteritis? |
|
Definition
| granulomatous early to nonspecific fibrosis later |
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Term
| What disease presents with polymyalgia rheumatica? |
|
Definition
|
|
Term
| What disease presents with amaurosis fugax and why is it important to find quickly? |
|
Definition
giant cell arteritis
important to find quickly b/c it will progress to blindness |
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|
Term
|
Definition
|
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Term
| What disease presents with fever and unilateral headaches? |
|
Definition
|
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Term
| In polymyalgia rheumatica what type of muscle atropy is there and what two parts of the body are achy? |
|
Definition
type II atropy
Shoulders and back |
|
|
Term
| What is true of teh ESR in Giant cell arteritis? |
|
Definition
|
|
Term
| What is the main characteristic finding in Takayasu arteritis? |
|
Definition
| pulseless upper extremities |
|
|
Term
| Which vasculitis presents with jaw claudation? |
|
Definition
|
|
Term
| What type of inflammatory response has giant multinucleated cells? |
|
Definition
|
|
Term
What causes palpable purpura?
What causes non-palpable purpura? |
|
Definition
fibrous necrosis
hemorrhage |
|
|
Term
| A young eastern lady comes into your office with a vasculitis associated with an absent pulse, what does she have? |
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Definition
|
|
Term
| What vasculitis involves the muscular arteries? |
|
Definition
|
|
Term
| What type of inflammation is present in Polyarteritis nodosa? |
|
Definition
|
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Term
| What vasculitis disease presents with lesions of different ages occuring at once? |
|
Definition
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|
Term
| Which vasculitis is associated with HEP B 30% of the time? |
|
Definition
|
|
Term
| What is the immune process in polyarteritis nodosa? |
|
Definition
|
|
Term
| What vasculitis will often lead to infarction? |
|
Definition
|
|
Term
| What is the pathologic process in polyarteritis nodosa? |
|
Definition
|
|
Term
| What type of kidney disease will be present in a patient with polyarteritis nodosa? |
|
Definition
| Arteritis causes renal HTN |
|
|
Term
| What disease has a unique sign of livedo reticularis and what is livedo reticularis? |
|
Definition
it is found in polyarteritis nodosa
livedo reticularis is a linear purple lesion on the skin |
|
|
Term
Which vaculitis commonly leads to aneurysms?
Where are they most likely to be found? |
|
Definition
polyarteritis nodosa
aneurysms found in GI tract and kidney |
|
|
Term
| YOu have a patient with vasculitis presenting with polyneuropathy and renal HTN, what is the most likely dx? |
|
Definition
|
|
Term
What are the two types of ANCAs?
What diseases studied are associated with each? |
|
Definition
c-ANCA: Wegener's Granulomatosis
p-ANCA: microscopic polyarteritis
Churg Strauss Syndrome |
|
|
Term
| What is the mechanism of destruction for the ANCA? |
|
Definition
the ANCA's are anti-neutrophilic cell antibodies that will seek out neutrophils and destroy them
this causes the release of neutrophil granules and destruction of tissue and damage to endothelium |
|
|
Term
| What is the pattern of distribution c-ANCA and what is the antibody against in the neutrophil? |
|
Definition
| it is diffuse and against protienase |
|
|
Term
| What is the pattern of distribution and the antibody that p-ANCA is directed against? |
|
Definition
| perinuclear and against myeloperoxidase |
|
|
Term
| What vasculitis diseases studied attack small vessels? (5) |
|
Definition
microscopic polyarteritis
wegeners granulomatosis
churg strauss syndrome
Henoch-Schonlein
Lupus |
|
|
Term
| What two general locations are the granulomatosis found in Wegener's Granulomatosis? |
|
Definition
|
|
Term
| What ist he classic triad for involvement for Wegener's granulomatosis? |
|
Definition
granulomatosis in upper respiratory tract
granulomatosis in lung
pacci immune renal disease |
|
|
Term
| What is pacci immune tell you? |
|
Definition
| no immune complexes in kidney seen on immunofluoresence |
|
|
Term
| Which vasculitis is pacci immune? |
|
Definition
|
|
Term
| What disease can present with sinusitis, oral ulcerations, dypsnea, cough, hemoptysis? |
|
Definition
|
|
Term
| Out of the three ANCA vasculitis which two have the most likely chance to involve the kidney? |
|
Definition
| Wegeners and Microscopic polyangiitis |
|
|
Term
| What vasculitis is it classic to discover upon new onset of asthma or rhinitis? |
|
Definition
|
|
Term
| What vasculitis is there the presence of >10% eosinophils in the blood? |
|
Definition
|
|
Term
| What is the most common cause of death in Churg Strauss syndrome? |
|
Definition
|
|
Term
| Which vasculitis presents with pulmonary infiltrates, skin nodules, and motor/sensory neuropathy? |
|
Definition
|
|
Term
| What three vasculitis have granulomatous involement? |
|
Definition
Giant Cell Arteritis
Wegener's Granulomatosis
Churg-Strauss Syndrome |
|
|
Term
| What vasculitis looks very similar to Polyarteritis nodosa but occurs in smaller vessels? |
|
Definition
|
|
Term
| What five organs does microscopic polyangiitis often involve? |
|
Definition
| skin, kidney, PNS, lungs, muscle |
|
|
Term
| What vascuilitis is the most common in children? |
|
Definition
|
|
Term
| What is the pathologic response in Henoch Schonlein purpura? |
|
Definition
|
|
Term
| What is the immunogic response in Henoch-Schonlein Purpura? |
|
Definition
|
|
Term
| What is Henoch-Schonlein Purpura usually preceded by? |
|
Definition
|
|
Term
| What is the prognosis for Henoch-Schonlein Purpura? |
|
Definition
|
|
Term
What is leukocytoclastic vasculitis?
What vasculitis is it present in? |
|
Definition
the breakdown of neutrophils creating nuclear dust
Henoch Schonlein Purpura |
|
|
Term
| What disease is the renal disease that can be present more severe in adults? |
|
Definition
|
|
Term
| What are the three common symptoms of Henoch-Schonlein Purpura? |
|
Definition
skin (palpable purpura)
Joints (althralgia)
GI (GI bleed, diarrhea, pain) |
|
|
Term
| What type of vessels does Henoch Schonlein purpura effect? |
|
Definition
|
|
Term
| What two vasculitis diseases are immune complex disorders? |
|
Definition
Polyarteritis Nodosa
Henoch-Schonlein Purpura |
|
|
Term
| What vasculitis is responsible for acute M.I. in young children? |
|
Definition
|
|
Term
| Where is Kawasaki most common in the world? |
|
Definition
|
|
Term
| What is the leading cause of acquired heart disease in children? |
|
Definition
|
|
Term
| What types of vessels does Kawasaki vasculits effect? |
|
Definition
|
|
Term
| What disesae is strongly associated with smoking? |
|
Definition
|
|
Term
| What disease makes one prone to autoampuation of fingers? |
|
Definition
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