Term
| Giant-cell (temporal) arteritis |
|
Definition
| Granulomatous inflammation; frequently involves the temporal artery. Usually occurs in patients older than age 50 and is associated with polymyalgia rheumatica. |
|
|
Term
|
Definition
| Granulomatous inflammation usually occurring in patients younger than age 50 |
|
|
Term
|
Definition
| Necrotizing inflammation typically involving renal arteries but sparing pulmonary vessels |
|
|
Term
|
Definition
| Arteritis with mucocutaneous lymph node syndrome; usually occurs in children. Coronary arteries can be involved with aneurysm formation and/or thrombosis. |
|
|
Term
|
Definition
| Granulomatous inflammation involving the respiratory tract and necrotizing vasculitis affecting small vessels, including glomerular vessels. Associated with PR3-ANCAs. |
|
|
Term
|
Definition
| Eosinophil-rich granulomatous inflammation involving the respiratory tract and necrotizing vasculitis affecting small vessels. Associated with asthma and blood eosinophilia. Associated with MPO-ANCAs. |
|
|
Term
|
Definition
| Necrotizing small-vessel vasculitis with few or no immune deposits; necrotizing arteritis of small and medium-sized arteries can occur. Necrotizing glomerulonephritis and pulmonary capillaritis are common. Associated with MPO-ANCAs. |
|
|
Term
| Giant-cell (temporal) arteritis |
|
Definition
| Large arteries (Aorta, aortic arch vessels to head, neck, extremities) |
|
|
Term
|
Definition
| Large arteries (Aorta, aortic arch vessels to head, neck, extremities) |
|
|
Term
|
Definition
| Medium arteries (usually renal arteries, sparing pulmonary) |
|
|
Term
| Kawasaki disease - Vessel Size |
|
Definition
| Medium arteries - possibly coronary |
|
|
Term
|
Definition
| Small arteries - including glomerular |
|
|
Term
|
Definition
| Immune complex mediated medium vessel vasculitis |
|
|
Term
|
Definition
| Anti-endothelial cell antibody mediated medium vessel vasculitis |
|
|
Term
|
Definition
| Small vessel vasculitis, few immune complexes, with eosinophilia, asthma and granulomas |
|
|
Term
|
Definition
| Small vessel vasculitis without few immune complexes, with eosinophilia, asthma and granulomas |
|
|
Term
|
Definition
| Small vessel vasculitis with few immune complexes, granulomas, no asthma |
|
|
Term
|
Definition
| Small vessel vasculitis with few immune complexes, without asthma or granulomas |
|
|
Term
|
Definition
| Small vessel vasculitis with immune complexes of IgA |
|
|
Term
|
Definition
| Small vessel vasculitis with immune complexes and cryoglobulin |
|
|
Term
|
Definition
| Medium vessel vasculitis with anti-endothelial cell antibodies |
|
|
Term
|
Definition
| Medium vessel vasculitis with immune complexes |
|
|
Term
| Giant Cell (Temporal) Arteritis |
|
Definition
| Affects primarily arteries in the head |
|
|
Term
| Giant Cell (Temporal) Arteritis |
|
Definition
| Medial granulomatous inflammation that leads to elastic lamina fragmentation |
|
|
Term
| Giant Cell (Temporal) Arteritis |
|
Definition
| Inflammatory lesions are non-continuous, with stretches of relatively normal artery. |
|
|
Term
| Giant Cell (Temporal) Arteritis |
|
Definition
| Occurs predominantly in older age individuals, with vague symptoms or facial pain and headache, sometimes involving the eye |
|
|
Term
| Giant Cell (Temporal) Arteritis |
|
Definition
| Degenerated internal elastic lamina and nodular intimal thickening |
|
|
Term
|
Definition
| Ocular disturbances and weakening of the upper extremity pulses |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Transmural fibrous thickening of the aorta, and luminal narrowing of the arotic arch vessels |
|
|
Term
|
Definition
| Shares many attributes with giant-cell arteritis, and diagnosis is often on the basis of age being less than 50 |
|
|
Term
|
Definition
| Classically involves the aortic arch |
|
|
Term
|
Definition
| Histological appearance is indistinguishable from giant-cell arteritis |
|
|
Term
|
Definition
| Younger ages, non-specific symptoms, with extremity weakness and ocular disturbances |
|
|
Term
|
Definition
| Medium artery vasculitis with segmental necrosis and without ANCA |
|
|
Term
|
Definition
| Medium artery vasculitis sometimes associated with hepatitis B |
|
|
Term
|
Definition
| Hepatitis B Antigen-Antibody complexes found in affected medium arteries |
|
|
Term
|
Definition
| Segmental transmural necrotizing inflammation of small to medium-size arteries |
|
|
Term
|
Definition
| Commonly involves medium arteries in the kidneys, heart and liver |
|
|
Term
| Giant Cell (temporal) Arteritis -or- Takayasu Arteritis |
|
Definition
| Infiltrate consists of CD4+ and CD8+ T-cells and multinucleated giant cells |
|
|
Term
|
Definition
| Transmural inflammation of the arterial wall with a mixed infiltrate of neutrophils, eosinophils, and mononuclear cells and fibrinoid necrosis |
|
|
Term
|
Definition
| Initial Fibrinoid necrosis followed by fibrous thickening of the wall of medium arteries |
|
|
Term
|
Definition
| Medium sized artery disease, only part of the circumference of the vessel wall affected |
|
|
Term
|
Definition
| Young person with severe hypertension due to renal artery vasculitis |
|
|
Term
|
Definition
| Acute, febrile, usually self-limited illness of infancy or childhood |
|
|
Term
|
Definition
| Child with fever and acute myocardial infact |
|
|
Term
| Giant-Cell (Temporal) Arteritis |
|
Definition
| Unexplained predilection for a single vascular site |
|
|
Term
|
Definition
| T-Cell cytokines and B-Cell autoantibodies injuring endothelial cells and smooth muscle cells of medium arteries |
|
|
Term
|
Definition
| Predilection for branch points and partial circumference lesions |
|
|
Term
|
Definition
| Necrotizing vasculitis that affects capillaries as well as arterioles and venules |
|
|
Term
|
Definition
| Also called Leukoclastic vasculitis |
|
|
Term
|
Definition
| All lesions tend to be the same age in a given patient |
|
|
Term
|
Definition
| Necrotizing glomerulonephritis |
|
|
Term
|
Definition
| Necrotizing glomerulonephritis and pulmonary involvment. |
|
|
Term
|
Definition
| Necrotizing vasculitis of medium and small vessels with "pauci-immune" lesions |
|
|
Term
|
Definition
| Segmental fibrinoid necrosis of media with focal transmural necrotizing lesions, but sparing of medium and larger arteries |
|
|
Term
|
Definition
| Hematuria, palpable purpura and hemoptysis aftter a course penicillin |
|
|
Term
|
Definition
| "Allergic granulomatosis" |
|
|
Term
|
Definition
| Small vessel vasculitis associated with asthma, allergic rhinitis, lung infiltrates, peripheral hypereosinophilia and extravascular necrotizing granulomas |
|
|
Term
|
Definition
| Asthma, eosinophilia, and palpable purpura |
|
|
Term
|
Definition
| Asthma, eosinophilia, and cardiomyopathy |
|
|
Term
|
Definition
| sometimes pANCA positive, can cause cardiomyopathy but not infarction |
|
|
Term
|
Definition
| Acute necrotising granulomas of upper respiratory tract, small-medium vessels, focal necrotizing crescentric glomerulonephritis |
|
|
Term
|
Definition
| Necrotizing granuloma, limited forms may be restricted to the respiratory tract |
|
|
Term
|
Definition
| PR3-ANCAs usually present |
|
|
Term
|
Definition
| Small vessel vasculitis affecting respiratory tract, cANCA positive (PR3) |
|
|
Term
|
Definition
| Ulcerative lesion of the nose |
|
|
Term
|
Definition
| Necrosis of glomerular capillary loops leading to parietal cell proliferation crescents |
|
|
Term
|
Definition
| Males affected more than females, average age around 40 |
|
|
Term
|
Definition
| 35 year old man with pneumonitis, bilateral nodular cavitary infiltrates and chronic sinusitis |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| Segmental, thrombosing, acute and chronic inflammation of medium and small arteries, often tibial and radial arteries |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| Male heavy cigarette smokers 20-40 years old |
|
|
Term
| Thromboangiitis Obliterans |
|
Definition
| Both genetic and smoking related |
|
|
Term
| Thromboangiitis Obliterans |
|
Definition
| Sharply segmental acute and chronic vasculitis of medium and small arteries, with thrombus and microabcesses |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| Inflammatory process uniquely extends into contiguous veins and nerves |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| Raunaud's Phenomenon, nodular phlebitis and pain in the medial foot |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| Foot pain induced by exercise and raunaud phenomenon |
|
|
Term
| Thromboangiitis Obliterans (Buerger Disease) |
|
Definition
| 30 year old male with ulceration of the toes, pain at rest and history of smoking |
|
|
Term
|
Definition
| Old man with hepatitis C and Raynaud phenomenon. |
|
|
Term
|
Definition
| 35 year old IV drug abuser with chronic hepatitis B, positive p-ANCA titer, blood pressure 230/140 and acute renal failure. |
|
|
Term
| Henoch–Schonlein purpura |
|
Definition
| 12 year old recently recovered from upper respiratory infection now has abdominal pain, joint pain, palpable purpura of the lower extremities and hematuria. |
|
|
Term
|
Definition
| 67 year old woman with recent pain chewing, headaches and blurred vision, with normal head CT and MRI. |
|
|
Term
Wegener Granuloma - cANCA (PR3) 95% cases, likely contributive
Churg-Strauss - pANCA (MPO) ~50% cases, probably contributive when present
Microscopic Polyangiitis - pANCA associated hypothesis
Kawasaki - anti-entothelial hypothesis |
|
Definition
| Vasculitides that may involve autoantibody mediated mechanisms |
|
|
Term
Giant Cell Arteritis
Takayasu Arteritis |
|
Definition
| The two major large vessel vasculitides |
|
|
Term
|
Definition
| A strictly small-medium vessel vasculitis |
|
|
Term
Giant Cell Arteritis
Takayasu Arteritis
Wegener Granuloma |
|
Definition
| Vasculitides with characteristically granulomatous lesions |
|
|
Term
|
Definition
| Affects large to medium, and sometimes small, arteries. |
|
|
Term
|
Definition
| Affects small or medium muscular arteries, but not arterioles, capillaries, or venules. |
|
|
Term
1) Polyarteritis Nodosa - "typically involving renal and visceral vessels but sparing the pulmonary circulation"
2) Takayasu Arteritis - about half of patients
3) Giant Cell - rare cases- "Giant Cell Aortitis"
4) Microscopic Polyangiitis - unlikely but possible (medium arteries)
5) Kawasaki unlikely but possible (medium arteries) |
|
Definition
| Vasculitides capable of producing renovascular hypertension, in order of likelihood |
|
|
Term
Polyarteritis Nodosa
Kawasaki Disease |
|
Definition
| Medium vessel vasculitis usually involving transmural inflammation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| anti-myeloperoxidase antibodies present, associated with Hepatitis B |
|
|
