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Vascular and Peripheral Vascular Disease
Clinical Medicine Module 6
76
Medical
Graduate
07/29/2009

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Term
55 yo male smoker w/htn, hyperlipidemia, claudication, decreased distal pulses, bruit, ulceration, LE pain/pallor that is worse w/elevation and improves w/dependency, numbness. Pulses heard by dopler, ABI below 0.9. What do you suspect? What tests do you order?
Definition
arterial occlusive dz. order ct, mra, or invasive angiography. (also color flow us. also interventional radiology)
Term
nml/abnml abi? how do you perform test?
Definition
nml 1-1.2; abnml below 0.9 cause for concern: ratio of systolic bp at ankle compared w/brachial artery in upper arm: ankle/brachial. pulses heard by doppler
Term
how do you tx arterial occlusive dz concervatively?
Definition
smoking cessation, weight loss, exercise program, reduction of risk factors, tight control of htn and diabetes, lowering lipid levels, phosphodiesterase inhibitor, cilostazol (used in tx of claudication)
Term
what is cilostazol
Definition
used in tx of claudication : inhibits platelet aggregation and provides arterial vasodilation
Term
when is sx tx indicated for arterial occlusive dz?
Definition
used to relieve the obstruction in pts w/sig dz that appears to be worsening, incapacitating, or interfering w/adls.
Term
2 types of bypass grafting and use of procedure
Definition
autogenous v. synthetic; used for arterial occlusive dz
Term
thromboendarterectomy: what is it and for what is it used?
Definition
sx removal of the atherosclerotic plaque. arterial occlusive dz
Term
endovascular surgery: what is it and for what is it used?
Definition
most helpful in lesions less than 10 cm long and in pts participating in aggressive risk factor modification; post-procedure antiplatelet medication usually required. arterial occlusive dz.
Term
what is subintimal angioplasty and when is it used?
Definition
transverse occluded vessel segments w/wire and re-enter true lumen distally
Term
etiology of acute arterial occlusion
Definition
embolus or thrombus of a dz atherosclerotic plaque enters into circulation and occludes an artery.
Term
3 dz involved w/acute arterial occlusion
Definition
atrial fibrillation, valvular dz, ischemic heart dz- mural thrombus
Term
most common location of occlusion
Definition
lower extremities (50%). other: cerbrovascular circulation (20%). upper extremities, mesenteric arteries, renal arteries (30%).
Term
Pt presents w/sudden onset of extremity pain, numbness and paralysis, absence of distil pulses, pallor worse w/elevation, cool extremity, and mottled color of skin. what do you suspect and how do you tx?
Definition
acute arterial occlusion. emergent revascularization, heparin (lmwh is better), aggressive anticoagulation, revascularization. (revascularization is key)
Term
What are 2 considerations for emergent revascularization? What does this tx?
Definition
open vs. endovascular procedure. sx vs. chemical thrombosis. acute arterial occlusion.
Term
What tx of acute arterial occlusion prevents clot propogation?
Definition
heparin
Term
What is still required as definitive tx w/metabolic acidosis as seroius complication?
Definition
acute arterial occlusion
Term
What is nml infrarenal aorta size? With what size do aneurysms present? At what size does it become problematic?
Definition
2cm. >3cm. >5cm.
Term
What age and sex of pt w/ what hx and what symptoms commonly present w/aaa?
Definition
55yo male w/hx smoking and asymptomatic to aaa. commonly found during routine pe: 80% of 5cm infrarenal aneurysms are palpable during abdominal examination.
Term
When do abdominal aortic aneurysms become symptomatic?
Definition
dissection
Term
55yo male pt w/hx of smoking, tachycardia, hypotension, diaphoresis, and pallor c/o mid-abdominal "tearing" pain radiating to lower back. what do you suspect?
Definition
aaa dissection
Term
3 p's of compartment syndrome
Definition
1. paresthesias. 2. pain out of proportion w/passive motion. 3. pulselessness.
Term
Half of detected aneurysms are under 5 cm in diameter. How many of these will increase sufficiently in size to require repair?
Definition
nearly 2/3
Term
nml size of infrarenal aorta; size for aneurysm?
Definition
2 cm=nml. >3cm=aneurysm
Term
Abdominal aneurysms originate where most frequently?
Definition
over 90% originate below renal arteries, and many extend into the common iliac arteries
Term
4 dx studies for aaa
Definition
plain radiograph, us, cat, cat w/iv contrast
Term
pt w/ back pain over 50 and you suspect kidney stone. what do you have to rule out before you can dx kidney stone?
Definition
aaa. (hypotension key). most are initially misdx.
Term
What imaging study for aaa is not dx but may id the aortic calcifications that suggest this pathology?
Definition
plain radiographs
Term
What's worse symptomatic aaa pt w/ bp of 100/60 or 160/100?
Definition
if they're sx they're leaking. low bp means they've lost more blood, high bp means they'll lose more blood.
Term
What dx study for aaa is the dx study of choice to id an aaa and obtain an initial dx?
Definition
us
Term
what imaging modality for aaa is test of choice to eval the diameter of the aneurysm?
Definition
cat scan
Term
What imaging study for aaa is ideal for planning for sx repair b/c of the ability to id vasculature above and below the aneurysm?
Definition
cat scan w/iv contrast
Term
how do you tx aaa<5.5cm
Definition
watchful waiting and tight control of underlying medical conditions
Term
how do you tx aaa 5.5 cm or >5mm expansion in 6 mos?
Definition
elective repair: open sx repair, endovascular repair
Term
how do you tx aaa symptomatic pts?
Definition
urgent operative repair is requried: endovascular- considered if the rupture is confined to the retroperitoneal space (tamponade effect); open sx approach- extremely high mortality
Term
Which is more common: aaa or taa? which is more lethal? are they more prevalent in m or f?
Definition
aaa more common. taa less common, but more lethal. male more than female.
Term
on what is pt outcome for taa dependent?
Definition
dependent upon size and onset of sx. like aaa most are asymptomatic
Term
55yo m presents w/chest pain that felt like "someone was tearing their chest open" radiating to the back, tachycardic, pale, hypertensive, cough, dysphagia, hoarseness. what might you suspect and what dx studies might you order?
Definition
taa. cxr: look for *widened mediastinum* and aortic calcifications, cat. (ddx: mi)
Term
Which dx study for taa is highly suggestive but not dx, showing aortic calcifications and widened mediastinum?
Definition
cxr
Term
what dx study for taa demonstrates anatomical position and size?
Definition
cat scan
Term
on what is tx of taa dependent?
Definition
location, size, rate of growth, and general medical condition of pt
Term
What size of taa are considered appropriate for sx repair? What 2 sx approaches might be considered?
Definition
6cm/larger. endovascular- preerred in aneurysms of descending thoracic aorta. open sx approach.
Term
What is the most common complication for taa vs. aaa tx?
Definition
aaa: pulmonary. taa: pulmonary
Term
tall slender male w/long fingers presents w/chest pain radiating to back, cough, dysphagia, hoarseness. what might you suspect?
Definition
dissecting taa; marfans pt
Term
5 etiologies for chronic venous insufficiency
Definition
dvt, trauma, obesity, superficial venus reflux, varicose vv
Term
Pt shows progressive "lower extremity" edema, changes in skin pigmentation, sub-q liposclerosis, ulcerations. what do you suspect? how might you tx? how might you tx the ulcerations?
Definition
chronic venous insufficiency. prevention of underlying conditions, compression stockings, avoid prolonged sitting and standing, leg elevation. ulcerations: control edema, increase venous circulation through compression ("pumping action of calf")
Term
What involves "dilated, tortuous vv in lower extremities"?
Definition
varicose vv
Term
what vv are primarily involved w/varicose vv?
Definition
greater saphenous vein and its branches
Term
What are s/s of varicose vv?
Definition
commonly asymptomatic but may be associated w/an aching type of discomfort, edema, venous stasis ulcers, or skin hyperpigmentation
Term
For what should every pt w/varicose vv be evaluated?
Definition
occlusive arterial dz: claudication, diminished pulses
Term
How does the severity of symptoms correlate w/the no and size of the varicosities?
Definition
does not correlate: dull, aching heaviness or discomfort; fatigue
Term
nonsx vs sx tx of varicose vv
Definition
nonsx: compression stockings, sclerotherapy. sx: phlebectomy, endovenous ablation (radiofrequency, laser)
Term
What involves "induration, erythema, and tenderness along a superficial v"?
Definition
venous thrombophlebitis
Term
What is the tx and course of tx for venous thrombophlebitis?
Definition
moist heat, nsaids, limb elevation. usually brief and benign course of tx. observe for the complication of septic thrombophlebitis
Term
virchow's traid
Definition
1)stasis, 2) intimal injury, 3)hypercoaguability
Term
most likely to develop ulcerations d/t chronic venous insufficiency
Definition
medial malleolus
Term
who made the critical connection of dvt to pe in 1856 and defined the mechanism of intravascular thrombosis?
Definition
virchow
Term
30yo female pt has calf/thigh discomfort w/edema, erythema, and recently flew back east from California afer having a tumor sx removed. pt smokes and is on birth control.
Definition
dvt. asymptomatic 50% of time. you must have high degree of suspicion in every pt and practice good preventative medicine b/c s/s and pe techniques unreliable
Term
What is the vasculature most commonly involved in dvt?
Definition
deep vv of lower extremities or pelvis. however, they can occur anywhere. 80% of dvt's arise from deep veins of calf.
Term
what percent of dvts propogate into the popliteal and femoral vv?
Definition
10% propogate
Term
dx test of choice for dvt
Definition
doppler us
Term
lower extremity venous eval indicated for what?
Definition
suspect acute dvt and/or superficial vv thrombosis, chornic venous insufficiency (chronic venous obstruction and/or valvular incompetence)
Term
hx arterial vs. venous acute vascular insufficiency
Definition
aa: pvd. vv: dvt risk factors
Term
pain for aa v. vv acute vascular insufficiency
Definition
aa: severe pain in foot and toes. vv: moderate pain in upper or lower leg
Term
edema for aa v. vv acute vascular insufficiency
Definition
aa: no edema. vv: sig edema
Term
color aa v. vv acute vascular insufficiency
Definition
aa: pale. vv: cyanotic
Term
pulses: aa v. vv acute vascular insufficiency
Definition
aa: no pulses. vv: palpable pulses
Term
an excellend dx tool that accurately reports the extent of aa insufficiency or occlusive dz and localizes and quantifies stenoses w/in the lower extremities
Definition
lower extremity arterial eval
Term
venous thrombophlebitis: inflammation or infection? #1 cause?
Definition
inflammation primary component: not infection. irritation/inflammation. NO ABX
Term
non-pharmacologic dvt prevention
Definition
elevate hob. intermittent pneumatic compression of lower extremities. compression stockings. early ambulation/physical therapy.
Term
pharmacologic dvt prevention/tx
Definition
anticoag: low dose heparin, lmwh, warfarin (coumadin)
Term
what pharmacologic dvt prevention/tx involves moderate bleeding complications, and need to monitor ptt (1.5-2.0)?
Definition
low dose heparin
Term
what pharmacologic dvt prevention/tx is expensive w/no need to monitor ptt?
Definition
lmwh
Term
what pharmacologic dvt prevention/tx is started after anticoabluation has been est and risks of bleeding se have decreased; maintain for at least 6 mo duration?
Definition
warfarin (coumadin)
Term
what dvt prevention/tx traps potential pulmonary emboli and maintains caval patency?
Definition
inferior venacaval filter
Term
what is the goal of dvt prevention/tx?
Definition
prevention of a life-threatening pulmonary embolus- cerebrovascular emoblic stroke is also a possiblitiy but far less common
Term
% dvt's found below knees
Definition
10%. 80% start below calf, but they don't occlude until further up leg.
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