Term
| ANCA associated vasculitis |
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Definition
affect both sexes, all ages (50 median)
WG more common caucasians of Euro descent
RF: s. aureus in upper airway, particulate silica, winter>summer, gentic, med- PTU, hydralazine, minocycline
hx: recent drug exposures, hx of hepatitis, disorder ass w/ vasculitis? |
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Term
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Definition
patient with systemic sx + single/ multi organ dysfuction
common s/sx: fatigue, weakness, arthralgias, abdominal pain, HTN, RI, neuro dysfunction |
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Term
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Definition
allergic rhinitis + asthma+ peripheral eosiniphilia
manifestations: pulmonary nodules or infiltrates, glomerulonephritis, skin, purpura, peripheral nervous system involvement
dx: peripheral blood eosinophilia, P-ANCA, bx
tx: prednisone |
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Term
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Definition
most common systemic vasculitis of sm & med vessels/ venules & arterioles
sx: URT, LRT, kidnesys, rhinitis--> saddle nose, pulomary nodules, aveolar hemorrhages, renal & vascuiliits
Dx: + C-ANCA, incr ESR, CXR, bx |
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Term
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Definition
pulmonary infiltrates/ nodules, aveolar hemorrhage, glomerulonephritis, skin-purpura
dx: + P-ANCA, CXR, tissue bx |
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Term
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Definition
induction= cyclophoshamide, glucocorticoids
maintenance- MTX, mcyophenolate mofteil, azathioprine |
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Term
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Definition
large vasculitis
most common systemic vascuiltiis in adults >50
most serous complication= blindess
sxL HA, PMR, jaw claudication, visual sx
dx: temporal artery bx, PMR- clinical, elevated ESR
tx: GCA= prednisone, vision loss- admit for IV steroids, PMR- prednisone taper |
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Term
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Definition
large vessel
women during reproductive years (mid 20s)
sx: absent pulse, bruit, claudication, HTN, FUO, fatigue, pain w/ exercise
dx: angiography, MRA, bx or aorta/affect vessel, elevated ESR/CRP, anemia
tx: prednisone 1mg/kg for 1 mo then taper, or other rheum drugs |
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Term
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Definition
medium vessel
+ HBV
sx: wt loss >4 kg, livedo reticularis, teste pain, myalgias, neuropathy, diastolic BP >90, elevated BUN/Cr, HBV
dx: anemia, thrombocytopenia, incr CRP/ESR, bx, angiography
tx: prednison 1 mg/kg, cyclophoshamide |
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Term
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Definition
medium vessel
active tobacco use
sx: non specific pain in calf/ foot/ toes--> severe pain/ amputation
dx: angiogrpahy
tx: smoking cessation, pain control |
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Term
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Definition
small vessel
oral ulceration + genital ulcers, eye lesion, skin lesions, + pathergy test
tx: topical steroids/ dapsone for oral ulcers, systemic steroid for vision, IF for refractory MM lesions |
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Term
| hypersenstivity vascuiltis |
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Definition
small vessel
onset <16, meds, palpable purpura, maculopapular rash
dx: elev ESR, bx
tx: remove offending agent, NSAIDs, persistant dz--> colcicine, hydroxycholorquine, dapsone, prednisone |
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Term
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Definition
small vessel
non thrombocytopenia purpura
deposition of IgA in walls of vessels
tetrad= pupura, arthritis, glomeruonephritis, abdominal pain
<20 y/o
tx: NSAIDs, dapsone, steroid? |
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Term
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Definition
+ HCV
Ig that precipatates in cold
tx: tx underlying viral infection, NSAID for arthralgias, steroids for vsaculitis, higher dose if necrotizing |
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