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Unit 4 Non-Specific Defenses
Unit 4 Non-Specific Defenses
19
Anatomy
Intermediate
06/08/2017

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Term
Pathogens
Definition
organisms that cause disease
Term
First line of defence includes
Definition
skin, stomach acid, tears and mucus in the trachea
Term
Second line of defence is non-specific eg
Definition
phagocytosis and Natural Killer Cells
Term
Third line of defence is specific eg
Definition
response by T-Lymphcytes and production of antibodies
Term
Mast cells are produced
Definition
from the same stem cells as white blood cells
Term
Mast cells release
Definition
histamine
Term
Histamine is a chemical that causes
Definition
blood vessels to vasodilate and makes capillaries more permeable
Term
An inflammatory response provides
Definition
additional blood to an injured area and causes it to swell up
Term
Cytokines are
Definition
cell signalling protein molecules secreted by many types of cell including white blood cells
Term
Phagocytes are attracted
Definition
by cytokines to the site of damaged tissue
Term
Blood clotting at an injured site
Definition
stops blood loss, prevents further infection and starts the tissue repair process
Term
Phagocytes detect
Definition
surface antigens on a pathogen and move towards it
Term
Phagocytes engulf the invader by
Definition
infolding of the cell membrane to create a vacuole
Term
Lysosomes in the phagocytes cytoplasm
Definition
fuse with the vacuole and release enzymes which digest the invader
Term
Pus is an accumulation of
Definition
dead bacteria and phagocytes
Term
Pores in a target cells membrane allow a
Definition
“signal” molecule from the NK cell to enter the target cell and trigger a genetically controlled series of events
Term
Target cells switches on
Definition
suicide genes and suicide proteins are released
Term
Suicide proteins function as
Definition
self-destructive enzymes break down cells DNA and vital proteins into useless fragments and the cell shrinks and dies
Term
Apoptosis is the
Definition
process of programmed cell death
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