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Unit 3 - Drugs of Abuse
Test 1
129
Nursing
Undergraduate 3
06/13/2014

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Term
What is addiction?
Definition
A compulsive, uncontrollable craving for and dependence on a substance to such a degree that cessation causes severe emotional, mental, or physiologic reactions
Term
What is a craving?
Definition
Subjective need for substance after decreased use or abstinence
Term
What is dependence?
Definition
Reliance on a substance that has reached a sufficiently high level so that its absence will cause an impairment in function
Term
What is drug abuse?
Definition
Overindulgence in and dependence on a substance that has a negative impact on psychologic, physiologic, and social functioning of an individual
Term
What is drug misuse?
Definition
Indiscriminate use of a drug for purposes other than those for which it is intended
Term
What is relapse?
Definition
Return to substance use during abstinence
Term
What is tolerance?
Definition
Decreased effect of a substance that results from repeated exposure.
Term
What are the addictive states?
Definition
-Intoxication
-Detoxification
-Withdrawal syndrome
-Cessation and maintaining abstinence
Term
What is intoxication?
Definition
A state of being influenced or affected by a drug or other toxic substance
Term
What is detoxification?
Definition
Involves treating an intoxicated client to diminish or remove drugs or their effects from their body
Term
What is withdrawal syndrome?
Definition
A group of s/s that occurs in a physically dependent person when drug use is stopped
Term
When is addictive treatment NOT a priority?
Definition
when client is in pain
Term
What should you do when addict is getting surgical treatment?
Definition
-Normal amounts of drugs may not be enough
-Anesthetic agents may have prolonged effect due to liver damage
-Increased doses of pain medication may be required with opiate addiction
-Increased risk for bleeding and post op complications and infection
-Withdrawal symptoms from CNS may be delayed for 5 days because of anesthetic and pain meds
Term
What is a serious concern among nurses?
Definition
Chemical impairment
Term
What is mandatory reporting?
Definition
House Bill 315 : Employers of RNs who suspected or observed a nurse of working impaired/or have diverted medications, to notify the Georgia Board of Nursing Board.
Term
What are the contributing factors to nurse impairment?
Definition
-chronic fatigue
-stress
- illness
-responsbility for clients responses to illness/dying
-professional dissatisfaction
-access to drugs
-martial and child issues,
-downszing
Term
What are the characteristics of nurse impairment?
Definition
Changes in personality, behavior, job performance, and attendance.
Term
What is the management of nurse impairment?
Definition
Largely dependent on state policies.
-Employment termination
-Rehabilitaion of nurses
Term
What are the stimulants?
Definition
-Nicotine
-Cocaine/amphetamines
-Benzphetamine
-Dextroaphetamine
-Methamphetamine
-Methylphenidate (Ritalin)
-Pemoline
-Phenmetrazine
-Caffiene
Term
What are the nicotine replacement agents?
Definition
-Gum
-Losenges
-Patch
-Nasal Spray
-Inhaler
Term
What are the s/e of nicotine?
Definition
-Increased arousal/alertness
-Performance enhancement
-Increase HR, output and BP
-cutaneous vasoconstriction
-fine tremor
-decreased appetite
-antidiueretic effect
-increased gastric mobility
Term
What are the s/e of other stimulants?
Definition
-Eupohria
-grandiosity
-mood swings
-hyperactivity
-hyperalertness
-restlesness
-anorexia
-insomnia
-hypertension
-tachy
-vasoconstriction
-tremor
-dysrhythmia
-seizures
-sexual arousal
-dilated pupils
-diaphoresis
Term
What is the safe amount of caffeine per day? adults
Definition
400 mg/day
Term
What is the safe amount of caffeine per day? chillens?
Definition
100 mg/day
Term
What are the complications from drug abuse?
Definition
Wernicke's encephalopathy and Krosakoff's Psychosis
Term
What is Wernicke's encephalopathy
Definition
Thiamine (vitamin B-1) deficiency causes inflammation, hemorrhage, and degeneration of brain.
Term
What is Korsakoff's psychosis?
Definition
late neuropsychiatric manifestation with short term memory loss, confabulation, and inability to learn.
Term
What is the treatment for drug abuse?
Definition
-Drug therapy for alcohol withdrawal
-Rehabilitation and sustained abstinence for everything
Term
What does C.O.P.E.S. stand for in alocholism?
Definition
C - Coping mechanisms
O - Orient to community resources
P - Plan may include antabuse
E - Encourage vitamin B, folic aicd
S - Seizures
Term
What is Revia?
Definition
Used for alcohol and narcotic dependence
Term
What does B.E.A.T. stand for with Revia?
Definition
B - Bleeding disorder, hepatic or renal impairment - Use w/ caution
E - Educate to avoid alcohol containing products
A - Addiction to alcohol or narcotics is the use
T - Take tablet w/ full glass of water or food
Term
What is antabuse used for?
Definition
Treatment of alcoholism. Disulfram rxn
Term
What is B.A.R.F. with antabuse?
Definition
B - bracelet should be worn (UE; N/V, weakness, sweating, liver toxicity)
A - acetaldehyde syndrome may occur. Watch for: respiratory arrest, cardiovascular depression, seizures, death
R - Remind client to avoid products containing alcohol
F - follow up w/ 12 step program
Term
What is Zolpidem Tartrate?
Definition
AMBIEN! A Sedative Hypnotic
Term
What teaching should be involved with Zolpidem (Ambien)?
Definition
Take just prior to going to bed as forgetfulness for events has been reported. 5mg dose for women; 10 mg dose for men.
Term
What does A.M.B.I.E.N. stand for w/ Zolpidem?
Definition
A Anxiolytic & hypnotic effects
M Morning drowsiness or hangover (modulates GABA
receptors to cause suppression of neurons)
B Beware of drug/drug effects w/Rifampin; Blurred vision
common side effect; Avoid tasks requiring driving
I Insomnia treatment
E Effects REM sleep pattern by suppressing it
N Non barbiturate; Not for long term use
Term
What are the pharmacokinetics of opiods?
Definition
The have the ability to activate the brain reward system, reinforcing their additive effect. They are taken orally, sniffed, smoked, injected sub q or intravenously. IV takes effects in seconds.
Term
What are the primary effects of opiods?
Definition
Analgesia
Drowsiness
Slurred speech
Detachment from the environment
IV - rush of feelings in the lower abdomen, warm skin flushing, and euphoria
Term
What is the antedote for opiod overdose?
Definition
Naloxone (Narcan)
Term
What are the symptoms of overdose?
Definition
-pinpoint pupils
-clammy skin
-respiration depression
-coma
-death
Term
What are the symptoms of opiod withdrawal?
Definition
Craving, abd cramps, diarrhea, n/v
Term
What is used to treat the withdrawal symptoms of opiods?
Definition
Methadone (Dolophine)
Clonidine (Catapres)
Term
What is an opiod antagonist?
Definition
Naltrexone (Trexan/ReVia)
Term
What is the antidote for benzodiazepines?
Definition
Flumazenil (Romazicon)
Term
What are the opioid drugs of abuse?
Definition
-Heroin
- Morphine
- Opium
- Codeine
-Fentanyl ( Sublimaze)
-Meperidine (Demerol)
-Hydromorphone (Dilaudid)
-Propoxyphene (Darvon)
-Oxycodone (OxyContin, Percocet)
-Methadone (Dolophine)
Term
What are the drug intrxns w/ opiods?
Definition
-CNS Depressants
alcohol
general anesthetics
sedatives/hypnotics
phenothiazines
antiemetics
-Mixed agonist/antagonist opiods
Term
What is used to treat opiod toxicity?
Definition
Opiod antagonist: Naloxone (narcan)
Term
What is used to treat withdrawal/dt from opioids
Definition
Opiod substitution: Methadone (Dolophine), Buprenorphine (Subutex), Cloidine (Catapres)
Term
What is used as maintenance therapy in opioid addiction?
Definition
Opiod Agonist: Methadone (Dolophine)
Opiod Antagonist: Neltrexone (ReVia)
Mixed: Buprenorphine (Subutex)
Term
What inhalants are abused?
Definition
-Volatile solvents
-Aerosols
-Anesthetic agents
-Nitrites
-Bath salts
Term
What do CNS sitmulants do?
Definition
Raise level of norepinephrine, serotonin, and dopamine
Term
What are the 3 categories of CNS stimulants?
Definition
-Amphetamines
-Analeptics, caffine
-Anorexiants
Term
What are the medically approved uses for CNS stimulants?
Definition
Attention deficit/hyperactivity disorder (ADHD)
Narcolepsy
Reversal of respiratory distress
Term
Which CNS stimulant treats ADHD?
Definition
-Amphetamines like ritalin,
Term
Which CNS stimulant treats narcolepsy?
Definition
-Amphetamines like Methyphendiate and modafinil (Provigil)
Term
Which CNS stimulant treats respiratory distress?
Definition
An analeptic like doxapram (Dopram)
Term
What is the pathophysiology of ADHD?
Definition
Disregulation of transmitters
Serotonin, norepinephrine, dopamine
Term
What is the epidemiology of ADHD?
Definition
Usually occurs in children before age 7
More common in boys
Term
What are the characteristics/symptoms of ADHD?
Definition
Inattentiveness, inability to concentrate, restlessness, hyperactivity, inability to complete tasks, impulsivity
Term
What are the characteristics of narcolepsy?
Definition
Recurrent attacks of drowsiness and sleep during daytime
Unable to control sleep


Falling asleep while
Driving
Talking
Eating
Standing
Term
What are Adderall/Dextroamphetamine (Dexedrine)?
Definition
Amphetamines
Term
What is the drug action of Adderall/Dextroamphetamine (Dexedrine)?
Definition
Stimulate release of norepinephrine & dopamine.
Term
What is Adderall/Dextroamphetamine (Dexedrine) used for?
Definition
-Increase wakefulness in narcolepsy.
-Increase attention span, cognition.
-Decrease hyperactivity, impulsiveness, restlessness of ADHD.
Term
What are the side effects of Adderall/Dextroamphetamine (Dexedrine)?
Definition
Tachycardia, palpitations, dysrhythmias, hypertension
Sleeplessness, restlessness
Irritability
Anorexia, dry mouth, weight loss, diarrhea, constipation
Impotence
Term
What are the amphetamine like drugs used to treat ADHD?
Definition
Methylphenidate (Ritalin)
-Available in may forms!
Methamphetamine (Desoxyn)
Term
What are the amphetamine like drugs used to treat narcolepsy?
Definition
Modafinil (Provigil)
Pemoline (Cylert)
Term
What is the drug action of Methylphenidate (Ritalin)?
Definition
Acts on cerebral cortex, reticular activity system
Term
What is Methylphenidate (Ritalin) used for?
Definition
ADHD, fatigue, narcolepsy
Term
What does Methylphenidate (Ritalin) interact with?
Definition
Caffeine may increase effects
Decreased effects of decongestants, antihypertensives, barbiturates
May alter insulin effects
Term
What are the s/e of Methylphenidate (Ritalin)?
Definition
Tachycardia, palpitations, dizziness, hypertension
Sleeplessness, restlessness, nervousness, tremors, irritability
Increased hyperactivity
Anorexia, dry mouth, vomiting, diarrhea, weight loss
Thrombocytopenia
Term
What are the nursing interventions r/t Methylphenidate (Ritalin)?
Definition
-Give b4 breakfast and lunch
-Report irregular heartbeat.
-Record height, weight, and growth of children.
-Avoid alcohol, caffeine.
-Use sugarless gum to relieve dry mouth.
-Do not stop abruptly; taper off to avoid withdrawal symptoms.
-Counseling must also be used.
Term
What is the action of anorexiants?
Definition
Suppress appetite
Term
What are anorexiants used for?
Definition
Obesity
Term
What are the side effects of anorexiants?
Definition
Nervousness, restlessness, irritability, insomnia, palpitations, hypertension
Term
What is an anorexiant?
Definition
Dextroamphetamine (Dexadrine)
Term
What is an analeptic?
Definition
Something used to stimulate the CNS
Term
What are some analeptics?
Definition
Caffeine (coffee, chocolate, cold medications), theophylline, NoDoz
Term
What is the medical use of an analeptic?
Definition
Stimulate respiration in newborns
Term
What are the s/e of analeptics?
Definition
Restlessness, tremors, twitching
Palpitations, insomnia
Tinnitus, nausea, diarrhea
Psychologic dependence
Term
What is the analeptic used to stimulate the respiratory system?
Definition
Doxapram (Dopram)
Term
How long does doxapram (do pram) need to work?
Definition
20-40 seconds. Peaking in 2 mins
Term
What are the side effects of Doxapram (Dopram)?
Definition
Hypertension, tachycardia, trembling, convulsions
Term
What are the 2 types of sleep?
Definition
-REM
- Non REM
Term
What happens if sleep is interrupted?
Definition
the cycle begins again with stage 1 of NREM sleep.
Term
What is insomnia?
Definition
The inability to sleep
Term
Who does insomnia effect more?
Definition
Women
Term
How is insomnia treated?
Definition
Sedative-hypnotics
Term
What are the nonpharmacologic treatments of insomnia?
Definition
No daytime naps
Warm fluids to drink
Caffeine avoided 6 hr before bedtime
Heavy meals and exercise avoided before bedtime
Warm bath, reading, listening to music
Term
What are the prescription sedative-hypnotics?
Definition
-Barbituates
-Benzodiazepine
-Nonbenzodiazepine
Term
What are the OTC sedative-hypnotics?
Definition
Nytol, Tylenol PM
Diphenhydramine (Benadryl)
Melatonin
Term
What are the general side effects of sedative-hypnotics?
Definition
Residual drowsiness (hangover)
Drug dependence
Drug tolerance
Excessive depression
Respiratory depression
Withdrawal symptoms
Term
What pregnancy class are barbiturates?
Definition
Class D
Term
What drug schedule are barbiturates?
Definition
Class II
Term
What are ultra-short acting barbiturates used for?
Definition
A general anesthetic. Ex: Thiopental sodium
Term
What are the short-acting barbiturates used for?
Definition
Induce sleep
No residual drowsiness
Term
What is a short acting barbiturate?
Definition
Pentobarbital (Nembutal)
Secobarbital (Seconal)
Term
Who is Secobarbital (Seconal) contraindicated in?
Definition
Resp. depression, severe hepatic disease, preg, nephrosis, hypersensitivity.
Term
What do intermediate acting barbituates do?
Definition
Induce and sustain sleep
Residual drowsiness (hangover effect)
Term
What are some intermediate acting barbs?
Definition
Amobarbital (Amytal), butabarbital (Butisol)
Term
What are long acting barbiturates used to treat?
Definition
Used to control seizures
Term
What is an example of a long-acting barbiturate?
Definition
phenobarbital (Luminal)
Term
What is the action of Secobarbital (Seconal)?
Definition
depression of CNS
Term
What is Secobarbital (Seconal) used for?
Definition
Short-acting to treat insomnia
Sedation
Preoperative medication
Term
What are the side effects of Secobarbital (Seconal)?
Definition
Hangover, dizziness, paradoxical excitement in older adults, respiratory distress, laryngospasm
Term
What does Secobarbital (Seconal) interact w/?
Definition
Decreased respirations with alcohol, CNS depressants, and MAOIs
Term
What are the nursing interventions associated w/ barbiturates?
Definition
-Raise side rails for older adults as confusion may occur.
-Teach client to use nonpharmacologic methods to induce sleep.
-Instruct client to avoid alcohol and CNS depressants.
-Advise client not to drive motor vehicles or operate machinery.
-Advise client to report adverse reactions.
-Instruct client to withdraw gradually to avoid withdrawal symptoms.
Term
What is the drug action of Benzodiazepine hypnotics?
Definition
Interacts with neurotransmitter GABA to reduce neuron excitability
Term
What are Benzodiazepine hypnotics used for?
Definition
-Reduce anxiety
-Treat insomnia
Term
What is an Benzodiazepine hypnotics?
Definition
Temazepam (Restoril)
Term
What is a NON-BENZODIAZEPINE HYPNOTIC>
Definition
Zolpidem (Ambien)
Term
How does Zolpidem (Ambien) work?
Definition
Neurotransmitter inhibition
Term
How long should Zolpidem (Ambien) be used?
Definition
Treat short-term (less than 10 days) insomnia
Term
What should you avoid when taking sedative-hypnotics?
Definition
Alcohol
CNS depressants
Term
What are the nursing interventions associated w/ sedative-hypnotics?
Definition
First use nonpharmacologic methods.
Be attentive to safety.
Avoid alcohol, other CNS depressants.
Take 15 - 45 minutes before bedtime.
Report hangover effect.
Monitor BP, R.
Withdraw gradually.
Term
What is the purpose of general anesthesia?
Definition
Analgesia, muscle relaxation, loss of consciousness, amnesia
Term
What is the purpose of local anesthesia?
Definition
Analgesia in limited area
DO NOT PUT ON PERIPHERAL DIGITS
Term
What are the routes of anesthetics?
Definition
Inhalation
IV
Topical
Local
Spinal
Term
Where is the local anesthetic needed for a spinal anesthetic?
Definition
Subarachnoid space at the 3rd/4th lumbar space
Term
What are the side effects of spinal anesthesia?
Definition
Hypotension, headache
Term
What can decrease the risk of a cerebrospinal fluid leak at the needle injection point?
Definition
Remaining flat after surgery
Term
What is a hypnotic anesthetic?
Definition
Zolpidem (Ambien)
Term
What is a narcotic analgesic or benzodiazepine given 1 hour pre-op anesthetic?
Definition
-Morphine
-Midazolam (Versed)
Term
What is an anticholinergic anesthetic given 1 hour pre-op?
Definition
Atropine
Term
What barbiturate is given as an anesthetic?
Definition
IV Thiopental Sodium (Pentothal)
Term
What is a muscle relaxant/paralytic given before surgery?
Definition
Succinylcholine (Anectine)
Term
Why is atropine given b4 surgery?
Definition
to decrease secretions.
Term
What are the side effects of anesthetics?
Definition
Respiratory depression
Hypotension
Dysrhythmias
Hepatic dysfunction
Term
What are the nursing interventions r/t anesthetics?
Definition
- Monitor LOC
- Monitor respirations, HR, BP
- Monitor urine output
- Adminster analgesics until client fully recovers
Term
What is R.E.G.I.O.N r/t anesthesia?
Definition
R - respiratory paralysis
E - elimination
G - GI
I - Inform of procedure
O - Observe for hypotension
N - No trauma to extremities
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