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Unit 10 neuro
Vestibular System
55
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Undergraduate 3
11/04/2014

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Term
what are the two types of otolith organs?
Definition
utricle
saccule
Term
otolith organs encode what stimulus?
Definition
linear acceleration
Term
utricle detects what acceleration?
Definition
horizontal
Term
saccule detects what acceleration?
Definition
vertical
Term
the vestibular system does what?
Definition
converts input energy of one form into output energy of another form
Term
what mechanism is used in VS transduction?
Definition
hair cells
Term
what two parts is the VS divided into?
Definition
peripheral
central
Term
the peripheral component of the VS includes what?
Definition
sensory receptors
8th cranial nerve
Term
what are the sensory receptors of the peripheral VS?
Definition
hair cells
Term
what happens after the hair cells are activated?
Definition
causes an AP that is delivered to the 8th cranial nerve and then to the brainstem
Term
where is the vestibular nuclei?
Definition
brainstem
Term
what are the three primary roles of the VS?
Definition
1) signals position and movement of the head
2) gives a sense of balance
3) coordinates movements of the head and eyes both stationary and moving and facilitates smooth postural transitions
Term
what is the key role of the VS?
Definition
maintain eye stability during positional changes
Term
where are the vestibular receptors located?
Definition
in the temporal bone
Term
what are the names of the two types of fluid in the vestibular receptors?
Definition
endolyph
perilymp
Term
characterize endolyph.
Definition
a potassium rich fluid separating the membranous and bony parts
Term
characterize perilymp.
Definition
a sodium rich fluid separating the membranous and the bony parts
Term
describe the depolarization during hair cell transduction.
Definition
when the hair cells move toward the kinocilium (longest hair cell in the group) there is a rush of K+ in causing depolarization. The influx of Ca++ into the cell triggers the AP (releasing the neurotransmitter by exocytosis), which goes to the 8th cranial nerve.
Term
what is the kinocilium?
Definition
taller hair cell in the group
Term
when does the AP occur in a hair cell?
Definition
when K+ rushes in
Term
what happens when the hair cells don't move toward the kinocilium, but in the opposite direction?
Definition
hyperpolarization
Term
T/F both sides are active at the same time.
Definition
false
when one side is active the other side is quite
Term
otolith organs are receptors that detect what?
Definition
force of gravity and tilts of the head
Term
semicircle canals have receptors that detect what?
Definition
head rotation
Term
T/F the vestibular Labyrinth is a set of interconnected structures.
Definition
true
Term
the semicircle canals detect what type of acceleration?
Definition
angular
Term
what is the mechanism the semicircular canals use to create an action potential?
Definition
mechanotransduction
Term
how does mechanotransduction work?
Definition
fluid moves hair cells->
either hyper polarizes or depolarizes->
AP if depolarization occurs->
exocytosis->
release of the neurotransmitter
Term
T/F the semicircular canals are an open system.
Definition
false
closed
Term
where are the hair cells in the semicircular canals?
Definition
clustered in the ampulla
Term
what happens to the fluid if the head is turing the right?
Definition
the fluid is moving left
Term
in the case of the head moving to the right, what occurs in the left and right VLs?
Definition
left-depolarization as the fluid forces the hair cells to the kinocilia

right-hyperpolarization as the fluid moves to the left, forcing the hair cells in the opposite direction of the kinocilia
Term
T/F in the VLs the opposite is always occur with the movement of the head.
Definition
true
Term
how are macula oriented in the utricle?
Definition
horizontally
Term
how are macula oriented in the saccule?
Definition
vertically
Term
how are macula arranged?
Definition
basement cells under hair cells that project into a gelatinous membrane with a gelatinous cap with tiny crystals
Term
what is the mechanism to cause an AP that the macula use?
Definition
machnotransduction
Term
macula can detect what?
Definition
head tilt
acceleration and deceleration
Term
even without head tilt you can sense acceleration and deceleration because?
Definition
the gelatinous membrane on the macula shifts causing the hair cells to shift
Term
explain the central vestibular pathways.
Definition
1) the axons of the VL project to the 8th cranial nerve and the vestibular nuclei.
2) the vestibular nuclei in the brainstem, the projects to the cranial nerves that either terminate in the spinal cord or in cranial nerves that cause eye movements.
Term
if the vestibular nuclei project to the spinal cord, what two pathways are used?
Definition
lateral vestibulospinal tract
medial vestibulospinal tract
Term
where is the lateral vestibulospinal tract located?
what is it in charge of?
Definition
located at all levels
innervating all major muscle groups involved in maintain posture
Term
where is the medial vestibulospinal tract located?
what is it in charge of?
Definition
at cervical levels
innervates in the cervical region, muscles involved with posture
Term
explain the vestibule-ocular reflex.
Definition
as the head turns to the right the eyes turn to the left,
innervate muscles that terminate in the eyes because as the head turns, the eyes lag.
Term
why do the eyes lag as the head turns in the vestibulo-ocular reflex?
Definition
to allow for the image to stay on the retina longer and to keep the visual image smoother
Term
damage to the VS can cause what?
Definition
difficulty fixating or stabilizing the visual target
create an unstable target
Term
why would damage to the VS cause one to feel like the world is spinning?
Definition
medial and lateral vestibulospinal tract
there are multiple things at the same time can mess with physical stability
Term
what does accurate vision require?
Definition
the image remain stable on the retinas even though the head is moving
Term
how does the VOR work?
Definition
works by sensing rotations of the head then immediately commanding compensatory movement of the eyes in the opposite direction
Term
what is important to note that the VOR is vestibular driven?
Definition
it works well in the dark or with they eyes closed
think about driving on a bumpy road, the image remains still because of eye movements to compensate
Term
T/F the vestibular system is an absolute reference system.
Definition
true
Term
when did rosenhall find in his cadaver studies?
Definition
that the average number of hair cells of the semicircular canals in individuals was 40% less compared to normal
Term
what was the big message of rosenhall's study?
Definition
decrease in reflexive activity with age
Term
how could you help rehabilitation for someone with loss of balance?
Definition
multiplane rehabilitation to stimulate he VS
Term
since the VS is an absolute reference system to other systems what happens with a decline in the system?

what can this cause in older people?
Definition
the system reduces the ability to resolve visual and somatosensory conflict (processing visual stimuli in conjunction with somatosensoy input

dizziness
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