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Understanding Pathophysiology Chapter 3
Altered Cellular and Tissue Biology
43
Nursing
Undergraduate 1
07/24/2013

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Term
Hyperplasia
Definition
Increase in cell numbers
Term
Dysplasia (Atipical Hyperplasia)
Definition
Increase in cell numbers that are becoming undifferentiated
Term
Atrophy
Definition
Decrease in cell size
Term
Hypertrophy
Definition
Increase in cell size
Term
Metaplasia
Definition
A cell type that changes to a different cell type
Term
Hormonal Hyperplasia
Definition
Occurs mostly in uterus or breast
Term
Hypoxia
Definition
Lack of sufficient oxygen
Number one reason for cellular injury
Term
Ischemia
Definition
Lack of blood flow
Term
Anoxia
Definition
Total lack of oxygen
Term
Germ Cells
Definition
Can replicate and can grow back after dead or injured
Term
Somatic Cells
Definition
Cannot replicate (Neurons, Cardiac Myoocytes) and once dead will never grow back
Term
Hypoxic Injury
Definition
Decrease in ATP, causing failure of sodium-potassium pump and sodium-calcium exchange; Cellular swelling
Term
Free Radicals
Definition
Electrically uncharged atom or group of atoms having an unpaired electron that damage:Alteration of proteins, Alteration of DNA, Mitochondrial damage
Term
Lead
Definition
Infiltrates the blood, and increases intracellular calcium concentration
Term
Carbon Monoxide
Definition
Has an affinity for hemoglobin 300x that of O2
Skin will be bright red, O2 saturation will be 98%-100%, they will have altered mental status or severe headache, and HR BP and RR will be elevated
Term
Chemical Injury
Definition
Lead, carbon monoxide, ethanol (ETOH)
Term
Ethanol
Definition
Alcohol
Term
Mercury
Definition
Caused nowadays by fish and dental amalgams
Term
Social or street drugs
Definition
Opioid, Sedative Hypnotic, Psychomotor Stimulants, Phencyclidine-like drugs, Cannabinoids, Hallucinogens
Term
Blunt Force Injury
Definition
Application of mechanical energy to the body resulting in the tearing, shearing, or crushing of tissues
Contusion(Bruise) vs. hematoma(collection of blood), Abrasion(Scrape), Laceration(Jagged cut), Fractures
Term
Sharp Injuries
Definition
Incised wounds
Stab wounds
Puncture wounds
Chopping wounds
Term
Gunshot wounds
Definition
KE(kinetic injury) = ½ MV2
Entrance wounds:
Contact range entrance wound
Blow-back and muzzle imprint
Intermediate range entrance wound
Tattooing and stippling
Indeterminate range entrance wound
Exit wounds
Shored exit wound
Term
Asphyxial injuries
Definition
Failure of cells to receive or utilize oxygen appropriately
Suffocation (choking asphyxiation), Strangulation (hanging), Chemical asphyxiation (cyanide and hydrogen sulfide), Drowning
Term
Physiologic Atrophy
Definition
Thymus gland shrinking (expected)
Term
Pathologic Atrophy
Definition
Disuse atrophy (unexpected)
Term
Chronic Hypertension
Definition
Hypertrophy and cardiomegaly due to the heart having to work harder.
Term
COPD
Definition
Metaplasia; can turn into dysplasia and cancer
Term
Partial Liver Removal
Definition
Hyperplasia to make up for the lost tissue
Term
Cellular accumulations
Definition
Infiltrations; Accumulate in a cell unnaturally
Water, lipids, carbohydrates, glycogen, proteins, pigments, calcium, urate
Term
Prostoglandins
Definition
Primary inflammatory mediator
Term
Necrosis
Definition
Sum of cellular changes after local cell
Term
Coagulative Necrosis
Definition
Kidneys, heart, adrenal glands
Protein denaturation
Term
Liquefactive Necrosis
Definition
Neurons and glial cells of the brain
Hydrolytic enzymes
Bacterial Infection (Staph, Strep, E-Coli)
Term
Caseous Necrosis
Definition
Tuberculosis pulmonary infection
Combination of coagulative and liquefactive necrosis
Term
Fat Necrosis
Definition
Breast, pancreas, and other abdominal organs
Action of lipases
Term
Gangrenous Necrosis
Definition
Death of tissue from severe hypoxic injury
Dry vs. wet gangrene (Clostridium)
Term
Accumulation of injurious events
Definition
Theory of aging that states that accumulation of oxidants causes aging
Term
Genetically controlled program
Definition
Theory of aging that states that every time a cell divides we lose little pieces of information
Term
Cellular aging
Definition
Atrophy,
Term
Sarcopenia
Definition
Wasting away of muscle tissue
Term
Somatic death
Definition
Death of an entire person
Term
Antimortem changes
Definition
Decreased temperature, respiratory decrease, mottling
Term
Postmortem changes
Definition
Algor mortis(cooling of the body), Livor mortis(mottling), Rigor mortis(hardening), Postmortem autolysis
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