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UCI: Brain Disorders Final
Review Slides Terminology
275
Psychology
Undergraduate 4
12/08/2010

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Term
Pre-Occipital Notch
Definition
The notch that forms the dividing line between the temporal and occipital lobes
Term
Cell Body
Definition
The main portion of a cell that contains the nucleus, mitochondria, and other organelles necessary for the cell to survive
Term
Myelin Sheath
Definition
A layer of protective tissue wrapped around axons of nerve cells to hasten the transmission of action potentials
Term
Axon Hillock
Definition
The base of the axon, where it meets the cell body of the neuron
Term
Node of Ranvier
Definition
The small gaps between myelin sheaths in the myelinated axons
Term
Dendrite
Definition
The branched portion of a neuron set for sending depolarizations towards the cell body
Term
Pia Mater
Definition
the thin, shiny, inner protective layer of the meninges that "shrink wraps" the brain
Term
Corpus Callosum
Definition
the main connection of white matter that is integral for communication between the two cerebral hemispheres
Term
Neuron
Definition
the basic cell in the brain that processes and transmits information in the form of electrical and chemical signals
Term
Axon
Definition
the long nerve fiber that sends depolarizations away from the cell body of the neuron
Term
Cerebral Spinal Fluid
Definition
the fluid surrounding the brain and spinal cord that cushions the nervous system
Term
Meninges
Definition
the three protective layers of tissue between the brain and the skull
Term
Dura Mater
Definition
the durable, leathery outer protective layer of the meninges
Term
Arachnoid Mater
Definition
the spider web-like middle protective layer of the meninges that is filled with cerebral spinal fluid
Term
Frontal Lobe
Definition
The anterior portion of the cerebral cortex, involved in emotion, cognition, and executive control
Term
Central Sulcus
Definition
The sulcus dividing the frontal and parietal lobes, surrounded on each side by the motor and sensory cortex
Term
Lateral Fissure
Definition
the gap that divides the temporal from the frontal and parietal lobes
Term
Parieto-Occipital Sulcus
Definition
the sulcus that divides the parietal and occipital lobes
Term
Axial
Definition
A horizontal slice of the brain cut from left to right, giving a view from the top or bottom of the brain
Term
Coronal
Definition
A vertical slice of the brain cut from superior to inferior, giving a view from the front or back of the brain
Term
Parietal Lobe
Definition
the superior posterior portion of the cerebral cortex, superior to the occipital and temporal lobes, posterior to the frontal lobe
Term
Temporal Lobe
Definition
the inferior portion of the cerebral cortex, anterior to the occiptial lobe and inferior to the others
Term
Medial
Definition
A vertical slice of the brain cut down from the center, anterior to posterior, giving a view from left to right
Term
Sagittal
Definition
A vertical slice of the brain cut down from the center, from anterior to posterior, giving a view from left to right.
Term
Lateral
Definition
A vertical slice of the brain cut down from the center, anterior to posterior, giving a view from left to right
Term
Caudal
Definition
towards the bottom of the brain
Term
Inferior
Definition
towards the bottom of the brain
Term
Dorsal
Definition
towards the top of the brain
Term
Ventral
Definition
towards the bottom of the brain
Term
Rostral
Definition
towards the front of the brain
Term
Cerebellum
Definition
the small, highly ridged portion of brain that sits inferior to the cerebral cortex and posterior to the brain-stem
Term
Anterior
Definition
towards the front of the brain
Term
Posterior
Definition
towards the back of the brain
Term
Superior
Definition
towards the top of the brain
Term
Gyrus
Definition
A ridge of the cerebral cortex
Term
Sulcus
Definition
A valley of cerebral cortex
Term
Cortical Sheet
Definition
the outer, surface covering of cerebral cortex, composed of gray matter (neuron cell bodies)
Term
Cerebral Cortex
Definition
The large, folded part of the brain that sit above the cerebellum and brain-stem, made up of gray and white matter
Term
Traumatic Brain Injury
Definition
Damage to the brain as a result of external physical force
Term
Phineas Gage
Definition
Spike through frontal lobe, caused emotional changes.
Term
Thrombus
Definition
A clot or arterial plaque obstructing blood flow
Term
Embolus
Definition
A moving clot
Term
Aneurysm
Definition
A localized, blood-filled bulge of a blood vessel
Term
Brodmann's Areas
Definition
Histologically defined areas of the brain, grouped by similar cell types. Used to refer to the locations in the brain.
Term
Ischemia
Definition
restriction in blood supply
Term
Hemorrhagic Stroke
Definition
A stroke resulting from the blood bleeding into the brain, damaging tissue.
Term
Ischemic Stroke
Definition
A stroke resulting from restriction of blood flow into the brain.
Term
Transient Ischemic Attack
Definition
Mini strokes, same symptoms of a stroke, but temporary
Term
Middle Cerebral Artery
Definition
The artery that supplies the lateral cerebral cortex and anterior temporal lobes
Term
Anterior Cerebral Artery
Definition
The arteries that supply oxygen to the most medial portions of the frontal lobes and superior medial parietal lobes
Term
Stroke
Definition
a rapid loss of brain tissue and function as a result of disruption of the blood supply to the brain
Term
Hemorrhage
Definition
Bleeding, the lost of blood from the circulatory system
Term
Circle of Willis
Definition
A circle of arteries that supply blood to the brain
Term
Carotid Artery
Definition
one of the two arteries that supply the head and neck with oxygenated blood, the artery you take a pulse from on the neck
Term
Vertebral Artery
Definition
One of two blood vessels that run up the back of the neck and join at the base of the skull to form the basilar artery
Term
Basilar Artery
Definition
the artery that supplies the pons, cerebellum, posterior cerebrum, and inner ear
Term
Ventricle
Definition
CSF-filled cavaities in the brain, four total (left, right, third, and fourth)
Term
Choroid Plexus
Definition
The tissue in the ventricles responsible for the creation of CSF
Term
Lumbar Puncture
Definition
A method to withdraw CSF in a safe, low part of the spinal cord
Term
Arachnoid Granulations
Definition
The bubble-like portions of the arachnoid mater in the superior gap between the hemisphere that are responsible for the removal of CSF from around the brain to be recycled
Term
Hydrocephalus
Definition
A developmental disorder in which too much CSF is created, causing head enlargement, developmental problems, changes in eye gaze, and if left untreated, death. It is primarily treated with a shunt to siphon CSF away from the brain into the abdomen.
Term
Alzheimer's Disease
Definition
The most common form of dementia, characterized by the loss of memory, cognitive abilities, and widespread neurodegeneration
Term
Meningitis
Definition
Viral or bacterial infection of the meninges. Symptoms includes: rash, stiff neck, headache, vomiting, mental status change
Term
Encephalitis
Definition
Usually a viral infection of the brain tissue. Symptoms include personality changes, seizures, weakness
Term
Epilepsy
Definition
Chronic neurological disorder that is characterized recurring seizures
Term
Autism
Definition
Diffuse development disorder that impairs social interaction and communication
Term
Computed Tomography (CT) scan
Definition
x-ray scan used to create structural images of tissue
Term
Edema
Definition
Swelling due to excess fluid
Term
Neurodegeneration
Definition
Progressive loss of structure of function of neurons, including death of neurons
Term
Atrophy
Definition
Loss of cells
Term
Dementia
Definition
progressive decline in cognitive function due to damage or disease in the brain
Term
Prion
Definition
Infectious protein molecules
Term
Differential Diagnosis
Definition
A systematic method of diagnosis a disorder
Term
Mental Status
Definition
Psychological and Behavioral functioning determined through observation and questioning
Term
Structural Magnetic Resonance Imaging (MRI)
Definition
3 types.
Term
T1 MRI
Definition
Weighting with a contrast dye. Useful for evaluating brain tumor, ischemia, hemorrhage, and infection/inflammation.
Term
T2 MRI
Definition
Diffusion Weighting, meaning without contrast agent. Useful for evaluating brain tumor, ischemia, stroke, changes in myelination, chronic epilepsy, scarring, and edema.
Term
Functional Magnetic Resonance Imaging (fMRI)
Definition
Scanning that detects changes in blood flow in the brain to see which areas are functionally active. Useful for detecting early stroke and cognitive disorders (i.e. dementia)
Term
Electroencephalogram (EEG)
Definition
Uses electrodes placed either above (in most cases) or below the scalp (rarely in humans), electrical activity in the brain is recorded. Useful for evaluating seizures, level of arousal, delirium, and brain death.
Term
Positron Emission Tomography (PET)
Definition
Measures metabolism by using radioactively tagged metabolic molecules that have been injected into the bloodstream. Useful for disorders that have metabolic problems, such as dementia, stroke, and brain tumor.
Term
Fovea
Definition
the center of vision, where vision is most acute and color vision is best. Cone photoreceptors are most prevalent here.
Term
Retina
Definition
The back of the eyeball, considered a part of the brain, where light hits the photoreceptive cells and visual information begins being processed.
Term
Optic Nerve
Definition
Where the axons of the retinal ganglion cells leave the retina and head back towards the optic chiasm in the brain, taking with them visual information. This nerve is the reasons humans have a blindspot, because no photoreceptors cells exist where the optic nerve enters the eye.
Term
Retinal ganglion cells
Definition
Cells in the retina that receive input from modulatory neurons (which get input from photoreceptor cells) and transmit the information down the optic nerve to the brain.
Term
Photoreceptor Cells
Definition
Cells that line the back of the retina and have parts that change shape when they are hit with photon, allowing them to detect light in a certain part of the visual field. Humans have two main types, rods and cones, and there are three different subtypes of cones.
Term
Rods
Definition
Photoreceptor cells that are located outside the fovea. They are responsible for low-light vision (highly sensitive to light) and useful for detecting movement, but at the cost of visual acuity. They do not differentiate between colors.
Term
Cones
Definition
Photoreceptor cells that are located primarily in the fovea. They are responsible for high acuity vision, but take more photons of light to activate (good for daytime vision). There are three types, each most responsive to different wavelengths of light (corresponding to red, green, and blue), which, when combined, allow for color vision.
Term
Parvocellular
Definition
A visual processing stream that pools over fewer receptors. The cells involved (midget cells) have a sustained response and are involved in processing color, fine details, textures, and depth.
Term
Magnocellular
Definition
A visual processing stream that pools over many receptors, whose cells (parasol cells) fire in bursts and are useful for detecting motion
Term
Optic Chiasm
Definition
Where the optic nerves cross in the brain, allowing information from the left visual field (from both eyes) and the right visual field (from both eyes) to be separated and directed to the appropriate contralateral hemisphere.
Term
Thalamus
Definition
A part of the brain involved in sensory information from sensory organs to processing areas of the cerebral cortex.
Term
Lateral Geniculate Nucleus (LGN)
Definition
A part of the halamus where the visual processing streams pass through on their way to the optic radiations and primary visual cortex.
Term
Optic Radiation
Definition
Nerve pathway along the visual processing stream from LGN to primary visual cortex.
Term
Scotoma
Definition
An area of impaired or lost vision in the visual field
Term
Blind-sight
Definition
A phenomenon where people who are perceptually blind demonstrate some response to visual stimuli (because only part of their visual system is impaired, other parts my still function)
Term
Dorsal Pathway
Definition
Made up of multiple visual areas, it is one of two main visual processing streams after primary visual cortex. This pathway is involved in the perception for action.
Term
Ventral Pathway
Definition
Made up of multiple visual areas, it is one of two main visual processing streams after primary visual cortex. This pathway is involved in perception for recognition.
Term
Visual Agnosia
Definition
Inability to recognize and identify objects or persons despite having knowledge of the characteristics of the objects or persons.
Term
Apperceptive Agnosia
Definition
A disorder characterized by the inability to name, copy, or recognize visually represented objects. Shape perception and figure-ground segregation is impaired, but basic visual functions (color discrimination, luminance discrimination, visual acuity) and object identification based on non-visual cues are preserved.
Term
associative agnosia
Definition
A disorder in which visual object recognition is impaired (e.g. naming of visually presented objects, categorization, matching by function), but more or less preserved is elementary visual perception (e.g. matching and copying of visually presented forms and objects, drawing objects from memory, and non-visual object recognition.
Term
Object Agnosia
Definition
A disorder in which visual object recognition is impaired. (e.g. naming of a visually presented objects, categorization, matching by function), but more or less preserved is elementary visual perception. (e.g. matching and copying of visually presented forms and objects, drawing objects from memory, and non-visual object recognition)
Term
Prosopagnosia
Definition
A disorder in which faces cannot be recognized, but other forms of object recognition are unimpaired.
Term
Capgras Syndrome
Definition
The delusional belief that an acquaintance has been replaced by an identical-looking impostor. It may be seen in schizophrenia, dementia, and brain trauma.
Term
Fregoli Syndrome
Definition
The delusional belief that different people are in fact a single person who changes appearance or is in disguise, generally viewed with paranoia (that the "shape-shifting" person is out to get them).
Term
Cornea
Definition
The transparent dome-shaped anterior portion of the outer covering of the eye that covers the iris and pupil and is continuous with the sclera
Term
Lens
Definition
Situated behind the iris of the eye, it focuses light entering the eye into the retina
Term
Sclera
Definition
The white part of the eye that, with the cornea, forms the protective outer covering of the eye
Term
Iris
Definition
The colored portion of the eye, a muscular diaphragm that controls the size of the pupil, which in turns controls the amount of light that enters the eye.
Term
Cataract
Definition
An opacity in the lens that blocks light from reaching the retina
Term
Unilateral field loss
Definition
loss of an entire eye's vision due to tumor or trauma that results from the disconnection of the optic nerve
Term
Hemianopsia
Definition
Blindness in one half of the visual field in one or both eyes
Term
Bitemporal hemianopsia
Definition
Blindness in the other halves of the visual fields in both eyes, due to damage to the optic chiasm (Tumors are often the culprit)
Term
Binasal Hemianopsia
Definition
Blindness in the middle halves of the visual field in both eyes, due to damage to uncrossed fibers(often due to calcification of the carotid arteries, associated with hydrocephalus)
Term
Homonymous Hemianopsia
Definition
Blindness in the same hemisphere of the visual field in both eyes, due to damage to one hemisphere of cortex(often from stroke or trauma)
Term
Simultagnosia
Definition
A deficit with scene perception, with normal visual fields
Term
Dorsal Simultagnosia
Definition
A deficit in scene perception where the patient can only perceive one stimulus at a time.
Term
Ventral Simultagnosia
Definition
A deficit in scene perception where the patient can see multiple objects bu cannot recognize them (can navigate and count, but cannot read)
Term
Rod Monochromat
Definition
A person whose cone photoreceptors in the retina cannot absorb light and therefore relies only on rod vision (Sees in black and white with low visual acuity)
Term
Central Achromatopsia
Definition
An Impairment of color vision in the entire visual field that arises from cortical lesions.
Term
Akinetopsia
Definition
The inability to perceive motion that arises from a stroke, trauma to v5/MT, and from antidepressants
Term
Thalamus
Definition
The sensory relay station int he brain (located subcortically) for all sense except olfactory.
Term
Primary Somatosensory Cortex (S1)
Definition
A strip of cortex just posterior to the central sulcus, where the primary control of sensation occurs
Term
Primary Motor Cortex (M1)
Definition
A strip of of cortex just anterior to the central sulcus, where the primary control of motor movements occurs
Term
Phantom Limb Syndrome
Definition
A disorder characterized by having sensations (usually pain) in a limb that is no longer attached to the body.
Term
Cotard Syndrome
Definition
The delusional belief that one is dead, does not exist, is putrefying or has lost his/her blood or internal organs
Term
Olfactory Epithelium
Definition
A sheet of cells lining part of the nasal passages that contains olfactory receptors
Term
Olfactory Bulb
Definition
Located on the ventral surface of the brain, it is the first part of the central nervous system in olfaction
Term
Anosmia
Definition
Lack of the ability to smell
Term
Hyposmia
Definition
Decreased ability to smell
Term
Phantosmia
Definition
"Hallucinated smell", often unpleasant
Term
Dysosmia
Definition
Things smell differently than they should
Term
Hypersomia
Definition
An abnormally acute sense of smell
Term
Ageusia
Definition
Loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami.
Term
Premotor Cortex (PMA)
Definition
Located just anterior to M1 and inferior to SMA, it controls postural/trunk and large limb muscles, the planning of actions based on sensory cues, and refinement of movements based on sensory input with cerebellum.
Term
Primary Motor Cortex (M1)
Definition
Located just anterior to the central sulcus, in the frontal lobe, controls the execution of movement
Term
Supplementary Motor Area (SMA)
Definition
Located just anterior to M1 and superior to PMA, it is involved in planning learned sequences of movements, activity just prior to movement, and has strong connections with subcortical structures.
Term
Posterior Parietal Cortex (PPC)
Definition
Located posterior to sensorimotor cortex, it integrates sensory and motor portions of the brain, processes position of the body and objects in space, and controls eye movements.
Term
Corticospinal Tract
Definition
The fibers that connect cortex through the spinal cord to motor neurons throughout the body
Term
Upper Motor Neurons
Definition
Originate in motor region of the cerebral cortex and carry motor information down to a specific spinal cord level
Term
Lower Motor Neurons
Definition
Bring the nerve impulses from the upper motor neurons out to the muscle
Term
Hemiparesis
Definition
Weakness on one side of the body
Term
Anosognosia
Definition
A disorder where the patient is unaware of and denies their disability, often associated with paralysis and right dorsal parietal damage
Term
Hemispatial Neglect
Definition
A syndrome where patients are unaware of the world on one side of space, usually from damage to right posterior parietal cortex
Term
Gerstmann's Syndrome
Definition
A syndrome where patients have finger agnosia, problems with left/right differentiation, and problems with calculation and writing
Term
Apraxia
Definition
A disorder of motor planning involving the loss of the ability to carry out learned purposeful movements, despite having the desire and the physical ability to perform the movements
Term
Basal Ganglia
Definition
A group of cell bodies below cortex interconnected with the cortex, thalamus and brainstem that is involved in motor control, cognition, emotions and learning
Term
Hypokinetic
Definition
Decreased movement
Term
Hyperkinetic
Definition
Increased movement
Term
Parkinson's Disease
Definition
A disease characterized by slowly or loss of movement, muscle rigidity, and tremor at rest due to a loss of dopamine neurons in the basal ganglia
Term
Huntington's Chorea
Definition
A genetic neurological disorder due to a loss of cortical neurons (Especially in the inhibitory pathway of basal ganglia) causing a decline in mental abilities and uncoordinated, jerky body movements
Term
Hemiballismus
Definition
A disorder characterized by involuntary flinging motions of the extremities that increase with activity, due to loss of the inhibitory pathway of the motor loop.
Term
Ossicles
Definition
The ossicles (Also called the auditory ossicles) are the three smallest bones in the human body. They are connected within the middle ear space and serve to transmit sounds from air to the fluid-filled cochlea. The absence of auditory ossicles would constitute a moderate-to-severe hearing loss.
Term
Malleus
Definition
The malleus or hammer is a hammer shaped small bone or ossicles of the middle ear which connects with the incus and is attached to the inner surface of the ear drum.
Term
Incus
Definition
The incus or anvil is the anvil-shaped small bone or ossicle in the middle ear. it connects the malleus to the stapes.
Term
Stapes
Definition
The stapes or stirrup is the stirrup-shaped small bone or ossicle in the middle ear which is attached to the incus and oval window.
Term
Tympanic Membrane
Definition
The tympanic membrane is a thin membrane that separates the external ear from the middle ear whose function is to transmit sound from the air to the ossicles inside the middle ear.
Term
Oval Window
Definition
The oval window is a membrane-covered opening which leads from the middle ear to the vestibule of the inner ear.
Term
Cochlea
Definition
The coiled and channeled main structure of the inner ear, which contains three fluid-filled canals that run along its entire convoluted length; the fluid-filled canals are separated by membrane, on which thousands of hair cells (auditory receptors) are arranged and are stimulated by the vibration of the stapes.
Term
Otosclerosis
Definition
abnormal growth of the middle ear which can result in hearing loss. Seen in .5% - 10% of the population, usually starts in middle age. Exact causes are unclear - genetic factors play a role, viruses like measles may be involved as well. Treated with hearing aids and/or surgery to remove the stapes.
Term
Basilar Membrane
Definition
The basilar membrane which the cochlea of the inner ear is a stiff structural elemental that separates two liquid-filled tubes that run along the coil of the cochlea, forming a base for hair cells to transduce the sound waves in the cochlear fluid to electrical signals in the brain.
Term
Hair cells
Definition
the sensory receptors of the auditory system located on the basilar membrane in the cochlea that convert sound waves to nerve signals by having their hair-like stereocilia being physically moved by sound waves in the cochlear fluid.
Term
Organ of Croti
Definition
The organ of Croti is the organ in the inner ear of mammals that contains the hair cells (the auditory sensory cells).
Term
Superior Olive
Definition
A small body in the mid-pons section of the brainstem involved in the localization of sound by determining differences in the intensity and timing of neural responses from each ear for a particular sound
Term
Lateral Sulcus
Definition
The lateral sulcus (Also called sylvian fissure or lateral fissure; fissure = large sulcus) is the sulcus that divides the frontal and temporal lobes of the brain.
Term
Superior Temporal Gryus
Definition
The most superior gyrus in the temporal lobe, situated just below the lateral sulcus, on which much of auditory cortex.
Term
Superior Temporal Sulcus
Definition
The most superior sulcus in the temporal lobe, situated just below the superior temporal gyrus.
Term
Primary Auditory Cortex (A1)
Definition
The main area of cortex which first processes auditory information in the brain, situated on the inferior surface of the lateral sulcus.
Term
Conductive Hearing Loss
Definition
Mechanical hearing loss, resulting from blockage in the ear canal, a ruptured eardrum, or restriction of movement of tiny bones in the middle ear, which prevents sound vibrations being transferred to the cochlea. Seen in otosclerosis.
Term
Sensorineural Hearing Loss
Definition
Hearing loss caused by damage to sensory cells and/or nerve fibers of the vestibulocochlear nerve (auditory nerve / Cranial Nerve VIII), the inner ear, or central processing centers of the brain. Seen in many forms of congenital and acquired deafness.
Term
Tonotopic
Definition
Tones close to each other in terms of frequency are represented in topologically neighboring neurons in the brain
Term
Aphasia
Definition
From Greek for "Lack of Speech" that is not a result of deficits in sensory, intellectual, or psychiatric functioning, nor muscle weakness.
Term
Broca's Aphasia
Definition
Aphasia characterized by slow, effort-full speech output lacking function words, problems with grammar and articulation, in which patients rely on high-frequency content words. Patients have deficits in repetition, naming, and fluency, but can comprehend normally.
Term
Wernicke's Aphasia
Definition
Aphasia characterized by fluent, meaningless speech with many semantic errors and little understanding (often with anosognosia). Patients have deficits in repetition, naming, comprehension, and have paraphasic fluency.
Term
Paraphasia
Definition
a condition in which one loses the ability to speak correctly, substiuting one word for another, and changing words and sentences in an inappropriate way (e.g, "television for "telephone")
Term
Arcuate Fasciculus
Definition
The neural white matter pathway connecting Broca's area and Wernicke's areas.
Term
Conduction Aphasia
Definition
Aphasia due to damage to the arcuate fasciculus resulting in poor repetition and naming, but normal comprehension and fluency.
Term
Transcortical Sensory Aphasia
Definition
Apasia that is similar to Wernick's apasia, except that patients are able to repeat (but still do not comprehend)
Term
Trascortical Motor Aphasia
Definition
Aphasia associated with right hemiparesis that is similar to Broca's Aphasia, except patients are able to repeat and may have mild comprehension problems.
Term
Global Aphasia
Definition
Apasia, associated with right hemiparesis, characterized by severe communication difficulties in both speech and comprehension
Term
Transcortical Mixed Aphasia
Definition
Similar to global Aphasia, but patients are still able to repeat.
Term
Anomic Aphasia
Definition
Aphasia in which word-finding is severely impaired, usually from damage to parietal and/or temporal lobes, and patients resort to circumlocution.
Term
Amusia
Definition
Agnosia for music. It involves loss of the ability to recognize musical notes, rhythms, and intervals and the inability to experience music as musical.
Term
Speech Apraxia
Definition
A developmental or acquired problem with speech production not associated with the muscle weakness. Its symptoms include difficulty putting sounds and syllables together in the correct order to form words.
Term
Stuttering
Definition
A speech disorder characterized by flow of speech that is disrupted by involuntary repetitions and prolongations of sounds, syllables, words or phrases, and involuntary silent pauses.
Term
Cluttering
Definition
A fluency disorder characterized by problems with rate, word confusion, and disorganized thoughts. Patients often are most clear at the start of utterances, but rate increases and intelligibility decreases towards the end, and are often unaware of the disorder.
Term
Spoonerism
Definition
A type of cluttering; phonemic substitution, such as "Three cheers for our queer old dean!" (Dear old queen, referring to Queen Victoria)
Term
Malapropism
Definition
A type of cluttering; wrong word substitution, such as "Create a little dysentery among the ranks." ('dysentery' instead of 'dissent')
Term
WADA Test
Definition
A procedure to put one hemisphere of the brain to sleep for about a minute by injecting sodium amobarbital (a sedative) into one of the carotid arteries, used to determine whether specific functions are lateralized.
Term
Split Brain Patient
Definition
A patient who has had the corpus callosum, the major white matter tract connecting the two hemispheres, severed, cutting off communication between the hemispheres. The procedure is used as a last resort in cases of severe epilepsy to contain the seizures.
Term
Synesthesia
Definition
A phenomenon where stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway.
Term
Cross-Modal
Definition
Cross-Modal perception occurs when perception involves interactions between two or more different sensory modalities.
Term
Long Term Memory
Definition
Relatively permanent traces of experiences that happened more than 18-30 seconds ago. It's the "hard-drive" of human memory.
Term
Short Term (Working) Memory
Definition
Limited, active, transient traces of experiences that happened in the very recent past (no longer than a few seconds ago). It's the "RAM" of human memory.
Term
Declarative/Explicit Memory
Definition
Memory that can be consciously declared (facts)
Term
Semantic Memory
Definition
Factual Knowledge independent of time and place.
Term
Episodic Memory
Definition
Theoretical knowledge of a specific moment in time and place
Term
Procedural/Implicit memory
Definition
Memory for procedures, skills, and actions
Term
Amnesia
Definition
Memory Loss with inability to imagine the future, which can be caused by brain trauma, infection, surgery, or psychological factors.
Term
Anterograde Amnesia
Definition
Memory loss where new events are not stored in long term memory
Term
Retrograde amnesia
Definition
memory loss with the inability to recall some memory or memories of the past, beyond ordinary forgetfulness
Term
Transient Global Amnesia
Definition
Temporary memory Loss, generally for less than 24 hours
Term
Hippocampus
Definition
A "curly" structure in the medial temporal lobe, one on each side, which is very important in episodic memory and spatial navigation
Term
Long Term Potentiation
Definition
A 'coincidence detector' that changes neuron structure and is thought to underlie the formation of long term memories
Term
Amygdala
Definition
A structure located in the medial temporal love near the hippocampus that plays a key role in the emotions, such as fear and pleasure
Term
Dienchephalon
Definition
The curved portion of the brain that includes the thalamus and mamillary bodies and is part of the limbic system.
Term
Mamillary bodies
Definition
A pair of small round bodies, located on the undersurface of the brain, that form part of the limbic system.
Term
Korsakoff's syndrome
Definition
A syndrome characterized by abnormal eye moments, loss of coordination, tremors, confusion, confabulation apathy, and severe anterograde and some retrograde memory memory impairment. It usually caused by vitamin deficiency in alcoholism, or lesions to the thalamus and mamillary bodies.
Term
Baddeley and Hitch Model
Definition
A short-term/working memory model with three main components.
Term
Visuospatial Sketchpad
Definition
Part of the Baddeley and Hitch Model, this component stores the visuospatial information.
Term
The Phonological Loop
Definition
Part of the Baddeley and Hitch Model, this component stores the auditory information.
Term
The Central Executive
Definition
Part of the Baddely and Hitch Model, this component performs operations on things stored in the sketchpad or loop.
Term
Mild Cognitive Impairment (MCI)
Definition
Transition Stage between the mild cognitive decline of normal aging and more serious problems of dementia; about 50% progress to dementia.
Term
Dementia
Definition
Progressive decline in cognitive function due to damage or disease in the body beyond what might be expected from normal aging
Term
delirium
Definition
The acute, common symptomatic manifestation of early brain dysfunction, for any reason; rapid, fluctuating course
Term
Alzheimer's disease (AD)
Definition
the most common form of dementia, with initial problems in learning, memory, and planning that expand to include language, recognition, personality changes, and motor deficits
Term
Wandering
Definition
In this context, the tendency for someone with dementia to wander with a lack of apparent purpose, often becoming confused or disoriented
Term
Sundowning
Definition
An alteration in behavior in sync with the circadian rhythm that co-occurs with wandering, which may be due to sensory deprivation from low light conditions in the evening and fatigue
Term
Dementia with Lewy Bodies (DLB)
Definition
Dementia characterized by fluctuating cognition with great variation in attention and alertness from hour to hour, recurrent visual hallucinations, and the motor features of parkinsonism. Lewybodies are clumps of proteins in neurons.
Term
Fronto-Temporal Lobar Dementia (FTLD)
Definition
heterogeneous dementia disorders associated with atrophy in the frontal lobes and temporal lobes, with sparing of the parietal and occipital lobes. Symptoms include personality changes, problems with executive function and language problems with naming or fluency. (Subtypes: fronto-temporal, semantic, progressive non-fluent)
Term
Posterior Cortical Atrophy (PCA)
Definition
A dementia with initial prominent visual symptoms such as problems with visual field defects, contrast sensitivity, color discrimination, and feature recognition of complex objects, acalculia (loss of math skills), and little initial decline in memory
Term
Vascular/Multi-Infarct Dementia
Definition
A dementia with symptoms including problems with recent memory, wandering, shuffling walk, loss of bladder or bowl control, emotional liability, difficultly with instructions, and problems handling money.
Term
Dementia Pugilistica (Chronic Traumatic Encephalopathy)
Definition
A severe form of chronic traumatic brain injury, resulting in declining mental ability, problems with memory, parkinsonism, tremors, lack of coordinations, speech problems, unsteady gait, and inappropriate or explosive behavior.
Term
Wernicke's Encephalopathy
Definition
the abrupt onset of encephalopathy (brain disorder), ophthalmoplegia (eye paralysis), and ataxia (loss of coordination) induced by thiamine deficiency, usually from extreme dietary deficiency, often associated with chronic alcoholism
Term
Creutzfeld-Jakob Disease (transmissible spongiform encephalopathy)
Definition
The most common human prion disease, with symptoms including decline in cognition with memory loss, personality changes, hallucinations, and problems with speech, gait, or coordination.
Term
Depression
Definition
Mental Disorder characterized by a pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.
Term
anhedonia
Definition
the inability to experience pleasure or interest in formerly pleasurable or satisfying activities.
Term
Major Depressive Disorder (Unipolar Depression)
Definition
Mental Disorder characterized by having 5 or more depressive symptoms that last without remission for at least two weeks.
Term
Melancholic Depression
Definition
A type of major depressive disorder that is characterized by a loss of pleasure in most or all activities, psychomotor retardation, weight loss, guilt, and insomnia.
Term
Dysthymia
Definition
A less severe, but long-lasting depression that lasts for at least two years.
Term
Minor Depressive Disorder
Definition
Mental Disorder characterized by having 2 or more depressive symptoms for at least two weeks.
Term
Adjustment Disorder with Depressed Mood
Definition
A mood disturbance appearing as a psychological response to an identifiable event or stressor or where resulting emotional or behavioral symptoms are significant but do not meet the criteria for a major depressive episode.
Term
Catatonic Depression
Definition
A rare and severe form of major depression involving disturbances of motor behavior and other symptoms. The patient is mute, immobile or exhibits purposeless or even bizarre movements.
Term
Season Affective Disorder (SAD)
Definition
A depressive disorder where depressive episodes come on in autumn or winter and resolve in spring.
Term
Atypical Depression
Definition
A type of depression with mood reactivity and positivity, significant weight gain or increased appetite, hypersomnia, a sensation of heaviness in the limbs, and a significant social impairment from hypersensitivity to perceived interpersonal rejection.
Term
Postpartum Depression
Definition
An intense, sustained and sometimes disabling depression experienced by women within three months after giving birth that can last as long as three months.
Term
Cognitive Model
Definition
A model of depression that states that depressed patients hold pessimistic views of themselves, the world, and the future with recurrent patterns of depressive thinking, resulting in disordered information processing(Led to cognitive behavioral Therapy)
Term
Cognitive Behavioral Therapy
Definition
An empirically tested and widely used therapy for treating depression, in which patients typically meet in groups and are taught to alter their recurrent patterns of depressive thinking so that they can restore normal information processing.
Term
Learned Hopelessness Theory
Definition
A model of depression that states that the patient loses hope that life will get better, possibly based on early life experiences, and they believe that negative experiences are due to stable, global reasons.
Term
Monoamine Oxidase Inhibitors
Definition
Antidepressant medication that results in a general increase in monoamines, but carries dietary risks
Term
Tricyclic Antidepressant
Definition
Antidepressant medication used to treat depression named for its three-ring chemical structure.
Term
Selective Serotonin Reuptake Inhibitors (SSRI)
Definition
Antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain.
Term
Noradrenergic Serotonergic Reuptake Inhibitors (NSRI)
Definition
Antidepressant drug that acts similarly to SSRIs
Term
Electro-convulsive Shock Therapy
Definition
Electric Shock Therapy done by inducing an electrical current in the brain, but cannot reach very deep.
Term
Anxiety
Definition
Diffuse, vague feelings of fear and apprehension
Term
Anxiety Disorder
Definition
Normal anxiety response inappropriately provoked by homeostatic imbalance.
Term
Generalized Anxiety Disorder
Definition
Chronic anxiety, worry, and tension independent of external cause for at least 6 months.
Term
Obsessive-Compulsive Disorder
Definition
An anxiety disorder most commonly characterized by obsessive, distressing, intrusive thoughts and related compulsions which attempt to neutralize the obsessions
Term
Panic Disorder
Definition
A disorder characterized by recurring panic attacks (feelings of helpless terror) and fear of having them, often developing agoraphobia
Term
Agoraphobia
Definition
An anxiety disorder, often precipitated by the fear of having a panic attack in a setting from which there is no easy means of escape. As a result, suffers of agoraphobia may avoid public and/or unfamiliar places.
Term
Post-Traumatic Stress Disorder (PTSD)
Definition
An anxiety disorder in which patients have nightmares, flashbacks, increased arousal (sleeplessness, hypervigilance), depression, irritability, and avoidance of stimuli associated with a traumatic event such as war, rape, or assault.
Term
Phobia
Definition
An intense, irrational fear that interferes with normal behavior.
Term
Phineas Gage
Definition
A railroad foreman who had a railroad rod shoot through his prefrontal cortex (and face) that survived and had drastic personality changes as a result.
Term
Lobotomy
Definition
A procedure where ice picks are placed in the orbital sockets, up into the prefrontal cortex and wiggled around, destroying tissue, in order to treat a wide variety of mental illnesses
Term
Dorsolateral Prefrontal Cortex
Definition
The highest cortical area responsible for motor planning, organization, and regulation, which is involved in the integration of sensory and memory information and the regulation of intellectual function and action, and is also involved in working memory.
Term
Frontal Convexity Syndrome
Definition
A disorder characterized by apathy, indifference, occasional outbursts, stimulus-bound behavior, lacking of planning, psychomotor retardation, motor perseveration and programming deficits, poor word list generation, poor abstraction and categorization, and working memory deficits.
Term
Medial Frontal Syndrome
Definition
A syndrome characterized by the paucity of spontaneous movement and gesture, sparse verbal output, lower extremity weakness and loss of sensation, and incontinence.
Term
Orbitofrontal Cortex
Definition
The cortex that is involved in sensory integration, affective value of reinforcers, decision making, expectation, taste, flavor, and regulates planning behavior associated with sensitivity to reward and punishment
Term
Orbitofrontal Syndrome
Definition
A syndrome characterized by disinhibited, impulsive behavior, inappropriate jocular affect, emotional lability, poor judgement and insight, sexual disinhibition, lack of concern for others, and distractibility.
Term
Antisocial Personality Disorder
Definition
A disorder characterized by a failure to conform to social norms with respect to lawful behaviors, deceitfulness, impulsivity, failure to plan ahead, irritability, aggressiveness, reckless disregard for safety of self or others, consistent irresponsibility, lack of remorse, rationalization of crimes, superficial charm, and substance abuse.
Term
Tourette's Syndrome
Definition
A syndrome characterized by patients exhibiting multiple motor tics and at least one vocal tic (the tics are stereotypic, temporarily suppressible, nonrhythmic, and often preceded by an unwanted premonitory urge, and they wax and wane)
Term
Schizophrenia
Definition
A disorder characterized by hallucinations, delusions, disorganized speech and thought, absence of normal cognition or affect, flat affect, poverty of speech, and lack of motivation.
Term
Hallucination
Definition
A perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. (Think Sensory Disorder)
Term
Delusion
Definition
A fixed, false belief, in psychiatry considered a result of an illness (think thought disorder)
Term
Over-Inclusion
Definition
Jumping from idea to idea without the benefit of logical association
Term
Paralogic
Definition
Surface logic, but really seriously flawed
Term
Flat Affect
Definition
No emotion at all in face or speech
Term
Inappropriate Affect
Definition
Laughing at very serious things, crying at funny things
Term
Catatonic Behavior
Definition
Unresponsiveness to environment, usually marked by immobility for extended periods
Term
Echolaia
Definition
Parrot-Like repetition of speech
Term
Dopamine
Definition
A neurotransmitter that affects mood, energy, sexual desire and motor coordination
Term
Tardive Dyskinesia
Definition
A possibility permanent disorder of involuntary, repetitive, purposeless movements as a side effect of long-term or high-dose use of dopamine antagonists, usually antipsychotics
Term
Schizoaffective Disorder
Definition
A disorder in the schizophrenic spectrum characterized by mood changes and psychosis
Term
Schizophreniform Disorder
Definition
A disorder in the schiziphrenic spectrum characterized by symptoms of schizophrenia for less than 6 months, less social dysfunction than schizophrenia, and a more likely recovery
Term
Shizotypal Personality Disorder
Definition
A disorder in the schizophrenic spectrum characterized by symptoms of paranoia, social anxiety, inappropriate and reduced affect, lack of close relationships, magical thinking, and vague metaphorical speech
Term
Schizoid Personality Disorder
Definition
A disorder in the schizophrenic spectrum characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, and emotional coldness.
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