Calcineurin inhibitors, such as _____ and ______, are the backbone of immunosuprresive regimens because they inhibit _____ and thereby block T-cell activation.

Cyclosporine

Tacrolimus

IL-2

Azathioprine

Mycophenolate

They inhibit T-cell proliferation

alters T-cell response to IL-2, but causes thrombocytopenia, anemia, and hyperlipidemia

reverse rejection by binding to antigen on T-lymphocytes (killer cells) and interfering with their function

Daclizumab

Besiliximab

naturally occuring hormones that prevent or suppress inflammation and humoral immune responses

Increase risk of infection and increase development of lymphoma and skin malignancies; associated with increase risk of congenital malformation and spontaneos abortions when used during pregnancy

Tacrolimus

Cyclosporine

Sirolimus

Do not get immunizations/vaccinations without the consent of your doctor. The use of live attenuated vaccines should definitely be avoided. Avoid contact with people who have recently oral polio vaccine or nasal flu vaccine

Patients are vulnerable to developing infections due to their suppressed immune system. Avoid contact with peole who have the flu or other contagious illness. Practice infection control techniques such as good hand washing.

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