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Translation
Biology 200 Lecture Notes
9
Biology
Undergraduate 2
07/20/2011

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Term
What do ribosomes catalyze?
Definition
Peptide bond formation.
Term
What does the A site hold?
Definition
An aminoacyl tRNA.
Term
What does the P site hold?
Definition
The tRNA with growing polypeptide attached.
Term
What does the E site hold?
Definition
A tRNA that will exit.
Term
What are the three phases of translation?
Definition
Initiation, elongation, termination.
Term
What is the first step of translational elongation?
Definition
An aminoacyl tRNA carrying the correct anticodon for the mRNA codon enters the A (acceptor) site.
Term
What is the second step of translational elongation?
Definition
A peptide bond forms between the amino acid on the aminoacyl tRNA in the A site and the growing polypeptide in the P (peptide-bond-forming) site.
Term
What is the third step of translational elongation?
Definition
The ribosome moves ahead three bases and all three tRNAs move down one position; the tRNA in the E (exit) site exits.
Term
What is needed to hold amino acids and interact with mRNA codons? Why doesn't transcription need this?
Definition
An adapter molecule. Transcription does not need this because NTPs and dNTPs can directly form base pairs.
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