Term
|
Definition
study of biochemical and physiological effects of drugs. relationship between the concentration at the receptor site and the response of the tissue to that drug. EX: liodcaine on heart muscle and the duration of the action potential of fibers.
> receptor binding, post receptor effects, chemical interactions. |
|
|
Term
|
Definition
| look at drug movement throughout body. Relationship between drug dose and drug blood level. Drug absorption, bioavailability, distribution, metabolsim, elimination. |
|
|
Term
| Five pharmacological parameters for serum drug concentration |
|
Definition
| Drug liberation, absorption, distribution, metabolism, excretion. |
|
|
Term
|
Definition
| SOME drugs is metabolized from the portal circulation reducing bio availability. fraction of drug that is absorbed and actually reaches the blood. Low bioavailability: quickly metabolized by liver, imeediately after being absorbed in the small intestine. |
|
|
Term
|
Definition
| point at which the concentration of the drug is in equilibrium with the rate of dose adminstration and the rate of elimiation. |
|
|
Term
|
Definition
| Oral dosing intervals give peaks and troughs in the dose response curve, while intravenous is constant. |
|
|
Term
|
Definition
|
|
Term
| Intravenous drugs model of elimination.. |
|
Definition
| biphasic/ two compartment with serum level rapidly falling in the first phase. Tissue vs blood/good tissues (profused). Ex: digixon. Lots can be accumulated in the tissues while target is fine. Oral route is uniformly distribution. One compartment. |
|
|
Term
| Aminoglycoside antibiotics... why pay attention to it? |
|
Definition
| Highly toxic, must perform peak and trough measurements. Concentrates at the kidneys bro! Toxic can damage kidneys and hearing. |
|
|
Term
|
Definition
| Rf values match with standards. Comparison to see what drugs it can contain. |
|
|
Term
|
Definition
| whole blood (trace element tube blue) with AAS.It intereferes with heme synthesis by binding to ALA's sulhydrl group. Navy blue top for others. |
|
|
