Term
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Definition
Anticoagulant rodenticide
- 1st generation, outdated
**LD50 in Dog = 20-300 mg/kg
- often contain 0.05%
- absorbed orally
- plasma half life = 14 hr (short)
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
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Definition
Anticoagulant rodenticide
- "tomcat", "Ramik", "Mousemaze"
- 1st generation, often contains 0.05%
**LD50 in dog = 0.9 -8 mg/kg**
- absorbed orally
- plasma half life = 4.5 days
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
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Definition
Anticoagulant rodenticide
- "Rozol"
- 1st generation, often contains 0.05%
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
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Definition
Anticoagulant rodenticide
- 2nd generation **most commonly sold and HIGHLY toxic!!**
~~LD50 in Dogs = 0.22-4 ~~
- used for warfarin resistance
- typical concentration 0.05%
- absorbed orally
- plasma half life = 6 days (much longer than warfarin)
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
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Definition
anticoagulant rodenticide
- 2nd generation (for warfarin resistance)
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
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Definition
Anticoagulant rodenticide
- 2nd generation, 0.05% concentration, for warfarin resistance
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- inhibits vitamin K epoxide reductase
- coagulopathy dose dependent |
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Term
| Anticoagulant Rodenticides |
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Definition
- accumulate and metabolized in liver
- excreted in urine, bile, milk, placenta
- absorbed orally
- MOA:blocks recycling of vitamin K from epoxide to reduced form (reduced is the active form)
- factors VII (early) and Factor IX (late) are affected
*inhibits vitamin K epoxide reductase*
delayed effect: depletion of clotting factors = clinical coagulopathy 3-6 days from ingestion
PT then PTT drops
- effects are dose dependent
- clinical signs= hemorrhage, blood loss, weakness, anemia, dyspena, epistaxis, melena, lameness, ataxia.
Tx: Supportive, Vitamin K1, blood/plasma transfusion
Dx: increased clotting time, PT, PTT, PIVKA, active ingredient present in blood/liver.
-whole blood = live sample
-liver = necropsy sample |
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Term
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Definition
Vitamin D3
-1 IU D3 = 25 ng cholecalicerfol
- delayed toxicosis in rodents 2-3 days post ingstion
-absorbed rapidly in SI> to liver & kidney> bile/feces excretion
-toxicity = 1-3 mg/kg
-Causes increase serum calcium
DX: increased Ca, P, BUN, Creatinine, USG 1.002
TX: saline, furosemide, pred, biphosphates |
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Term
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Definition
Vitamin D3 analog
- more potent than chloecalciferol
toxicity = 50 ug/kg
- causes increased serum calcium
DX: increased Ca, P, BUN, creatinine, USG 1.002
TX: saline, furosemide, pred, biphosphates |
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Term
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Definition
Rodenticide
- more toxic w/food
- Ph3 blocks cytochrome oxidase and membrane ion transport (myocardium)
- Difficult to Dx
- variable clinical signs
- dead fish/garlic odor
- volatile (freeze and seal tissue samples)
- TX: detox/suportive & prevent more liver damage |
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