Term
What are some cholecalciferol containing products?
What is the typical concentration? |
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Definition
Rampage, Quintox, Ortho Mouse-B-Gone
0.075% |
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Term
| What is the typical clinical signs of cholecalciferol poisoning? |
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Definition
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Term
| What are the toxicokinetics of cholecalciferol? |
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Definition
It is a form of vitamin D3, which is significantly more potent than vitamin D
Calcipitriol is a more baddass one
1mg equivalent to 40,000 IU of vitamin D
Lethal dose: - cholecalciferol is >5mg/kg
- calcipitriol is 50ug/kg
Susceptibility: Cats>Pups>Dogs |
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Term
| What is the mechanism of action of Cholecalciferol? |
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Definition
Cholecalciferol acts through normal vitamin D to (3):
1) increase Ca and P absorption through the gut
2) Causes PTH to increase osteoclast bone resorption
3) Renal retention of Ca via distal tubule resorption |
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Term
| What are the clinical signs of cholecalciferol toxicity? |
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Definition
| Conduction dysfunction, Hypertension, Polyuria, Azotemia |
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Term
| What are the blood values expected for Cholecalciferol? |
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Definition
| Elevated calcium (>12mg/dL), phosphorous (>7mg/dL), BUN, Creatinine, Hyposthenuria |
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Term
What are the clinical signs fo cholecalciferol toxicity?
When do they occur? |
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Definition
Initially anorexia, vomiting, depression, muscle weakness.
Progresses to renal tubular necrosis and mineralization of kidney, heart, lungs, stomach, intestine
Occurs 12-36hours after ingestion |
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