Term
| 4 functions of Endothelium |
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Definition
| Barrier Function, Antithrombotic activity, Effect on Vascular Tone, Smooth Muscle Cell proliferation. |
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Term
| Factors that recruit leukocytes |
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Definition
chemoattractant nature of modified LDL, expression of cytokines by injured endothelial cells (TNF, MCP), Expression of cell adhesion molecules (VCAM-1,
ICAM-1). |
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Term
| Order of high frequency atheroschlerosis |
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Definition
| 1. abdominal and iliac arteries 2. proximal coronary arteries 3. thoacic aorta, femoral, popliteal arteries 4. internal carotid arteries 5. vertebral, basilar & middle cerebral arteries. |
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Term
| What are signs and symptoms of CAD |
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Definition
| dyspnea, diaphoresis, nausea, cool and clammy skin |
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Term
| What are the 4 componenets of a lipoprotein? |
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Definition
| cholesterol, triglyceride, phospholipid, apoprotein. |
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Term
| What are the lipid risk factors for CAD? |
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Definition
| increased LDL, increase in apoB, increased Lp (a), decreased HDL, reduction in apo A-I, increased TG |
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Term
| Familial hypercholesterolemiz |
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Definition
| Defect in gene encoding LDL receptors. Autosomal dominant disorder. |
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Term
| 3 ways HDL is a therapeutic chemical |
|
Definition
| increase APO 1 production, promote reverse cholesterol transport, delay catabolism of HDL |
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