Term
| List the 4 steps in wound healing |
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Definition
1. Hemostasis
2. Inflammatory Phase
3. Proliferation Phasae
4. Maturation |
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Term
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Definition
| Hemostasis occurs immediately after the initial injury. Involved blood vessels constrict and blood clotting begins through platelet activation and clustering. Shortly after the brief period of constriction, the same blood vessels dilate and capillary permeability increases which allows plasma and blood components to leak out into the area that is injured forming a liquid called *Exudate* |
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Term
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Definition
| Fluid that accumulates in a wound; may contain serum, cellular debris, bacteria and white blood cells |
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Term
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Definition
| The inflammatory phase follows hemostasis and usually last about 4-6 days. WBCs (typically leukocytes and macrophages) move to the wound. Leukocytes arrive first to ingest bacteria and cellular debris. About 24 hours later, macrophages enter the wound area and remain for an extended period; they are essential to the healing process. Not only do the macrophages ingest debris but they also release growth factors that necessary for the growth of epithelial cells and new blood vessels. These growth factors also attract fibroblasts that help to fill in the wound, which is necessary for the next stage of healing. |
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Term
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Definition
| Increased number of WBCs in the blood |
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Term
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Definition
| Proliferation phase is also known as the fibroblastic, regenerative or connective tissue phase. The proliferation phase last for several weeks. New tissue is built to fill the wound space, primarily through the action of fibroblasts. The new tissue called *granulation tissue* forms the foundation for scar tissue development. It is highly vascular, red, and bleeds easily. In wounds that heal by first intention, epidermal cells seal the wound within 24 to 48 hours, so the granulation tissue is not visible. By the end of the 2nd week following the injury, the majority of the WBCs have left the area and wound is lighter in color. |
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Term
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Definition
| The final stage of healing begins about 3 weeks after the injury (with the possibility to continue for months or even years). All of the collagen that was just previously dumped in the wound is now being remodeled, which makes the healed wound stronger and more like the adjacent tissue. New collagen continues to be deposited which compresses the blood vessels in the healing wound so that the scar, an avascular collagen tissue that does not sweat, grow hair or tan in sunlight, eventually becomes a thin flat line. Scar tissue is strong but less elastic than uninjured tissue. |
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