Term
| which is more potent T3 or T4? |
|
Definition
| T3 (3x's the strength of T4) |
|
|
Term
| HYPOthyroidism shows ___T4 and ___TSH |
|
Definition
|
|
Term
|
Definition
| dried animal thyroid gland |
|
|
Term
|
Definition
standardization
stability
ALLERGY |
|
|
Term
| Thyroglobulin USP is made from |
|
Definition
|
|
Term
|
Definition
standardization
stability
allergy |
|
|
Term
| Natural thyroid hormone preps |
|
Definition
Thyroid USP
Thyroglobulin USP |
|
|
Term
|
Definition
Liotrix
Liothyronin
levothyroxine |
|
|
Term
| what is composition of liotrix |
|
Definition
|
|
Term
|
Definition
|
|
Term
| which is more potent levothyroxime or liothyronine? |
|
Definition
|
|
Term
| AEs of liothyronine are < or > that of levothyroxine? |
|
Definition
|
|
Term
| levothyroxine is synthetic |
|
Definition
|
|
Term
| Liothyronine is synthetic |
|
Definition
|
|
Term
| Are all brands of levythyroxine formulations the same? |
|
Definition
NO!
vary by brand....substitutions can be significant |
|
|
Term
|
Definition
insomnia (not pm or hs dosing)
dysrythmias
hand tremor, HA
NVD, wt loss
mentrual irreg
rash |
|
|
Term
| levothyroxine OD resembles what |
|
Definition
HYPERthyroidism
nervousness irritability
N/V
sweating
angina |
|
|
Term
| what alters the absorbsion of levothyroxine |
|
Definition
cholestyramine
sucralfate
ANTACIDS!
**admin 2 hrs before or after** |
|
|
Term
| what decreases effect/levels of levothyroxine |
|
Definition
|
|
Term
| levothyroxine incr. levels of |
|
Definition
|
|
Term
| levothyroxine increases requirements for what |
|
Definition
oral hypoglycemic agents
aka diabetes drugs |
|
|
Term
| what are geriatric considerations for levothyroxine |
|
Definition
may need 25% less of drug
hypothyroid misdiagnosed (1/3 typical cold intol and wt gain)
also look for non spec s/sx (neuro) |
|
|
Term
| HYPERthyroidism shows ___T4 and ___TSH |
|
Definition
|
|
Term
| what causes HYPER thyroidism |
|
Definition
overprod of thyroid hormones
TSH tumor
graves |
|
|
Term
| how do you determine tx of HYPERthyroidism |
|
Definition
| based on severity and type |
|
|
Term
| what are the thiorea drugs? |
|
Definition
propylthiouracil (PTU0
methimazole |
|
|
Term
|
Definition
inhibits synth of thyroid hormone ->
stops oxidation of iodine in thyroid
Also stops periph conversion of T4->T3 |
|
|
Term
|
Definition
surgery prep or RAI
remission in 1/2
|
|
|
Term
| how should propylthiouracil be withdrawn? |
|
Definition
SLOWLY
monthly eval for 3 mos then q 3 mos |
|
|
Term
| does propylthiouracil effect hormones already circulating/stored? |
|
Definition
|
|
Term
|
Definition
pruritic macular rash
fever
hepatitis
arthralgias
SLE-like sx
decr WBC
agranulocytosis |
|
|
Term
| what should be monitored while on propylthiouracil? |
|
Definition
|
|
Term
| propylthiouracil shows cross sensitivity w/ what drug? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| drug interaction for propylthiouracil |
|
Definition
|
|
Term
|
Definition
inhibit synth of thyroid hormone.
|
|
|
Term
| does methimazole inhibit peripheral conversion of T3->T4? |
|
Definition
|
|
Term
| which acts more rapidly Methimazole or propylthiouracil? |
|
Definition
|
|
Term
| which takes longer to being working propylthiouracil or methimazole? |
|
Definition
|
|
Term
|
Definition
same as propylthiouracil
aceniform eruptions
incr. myelosuppression (> 40 mg/day) |
|
|
Term
| what dosage of methimazole incr myelosuppression |
|
Definition
|
|
Term
| what BB is used to tx HYPERthyroidism |
|
Definition
|
|
Term
|
Definition
| suppress symp s/sx of hyperthyroid |
|
|
Term
|
Definition
| symp relief of tachy, palpations, and dysrhythmias |
|
|
Term
| when is the onset of action for propranolol? |
|
Definition
|
|
Term
| Iodine salts for hyperthyroidism |
|
Definition
potassium iodine
saturated K iodine
radioactive iodine |
|
|
Term
| what is another name for saturated soln of k iodine (SSKI) |
|
Definition
|
|
Term
|
Definition
| inhibit release of thyroid hormones from thyroid gland |
|
|
Term
| when do you give K iodine pre-op |
|
Definition
|
|
Term
| what type of K iodine can escape suppression? |
|
Definition
|
|
Term
|
Definition
rash
salivary/parotid swelling
metallic taste
sore mouth/gums |
|
|
Term
|
Definition
|
|
Term
| who can administer radioactive iodine? |
|
Definition
|
|
Term
| who should not be given radioactive iodine? |
|
Definition
|
|
Term
| who should not be given propylthiouracil |
|
Definition
|
|
