Term
| What is the primary limitation to giving larger doses of chemotherapry? |
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Definition
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Term
| Which drugs in particular have steep dose responses? |
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Definition
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Term
| What is the goal of Hematopoietic Stem Cell transplant? |
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Definition
| Engraph bone marrow stem cells to help regenerate bone marrow |
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Term
| What is the ideal transplant for treatment of an aggressive tumor? |
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Definition
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Term
| Autologous transplant uses patient's own stem cells and is most effective at treating what tumors? |
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Definition
|
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Term
| What is the determinant marker for hematopoietic stem cells? |
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Definition
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Term
| How are stem cells acquired for autologous transplant (from what tissue) |
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Definition
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Term
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Definition
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Term
| What is the benefit of Synergeneic transplant vs autologous? |
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Definition
| There are no contaminating tumor cells collected in the samples and given to the patient |
|
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Term
| What is the disadvantage of synergeneic transplant vs autologous? |
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Definition
| There is no immunologic attack on the tumor cells |
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Term
| What are the advantages of HLA-matched Allogeneic transplant? |
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Definition
| No malignant cells collected AND there is a chance for graft vs malignancy effect |
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Term
| What is the main disadvantage of Allogeneic transplants? |
|
Definition
| Hard to find a proper donor |
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Term
| Any transfusions given to immunosuppressed patients should undergo what process first? |
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Definition
| irradiation to kill off leukocytes |
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Term
| What are the three target organs for Acute GVHD? |
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Definition
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Term
| What population is Nonmyeloablative (reduced-intensity) transplant most useful for? |
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Definition
| The elderly, who are less likely to tolerate high dose chemotherapy |
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Term
| What four conditions normally cause elevation of PT but normal PTT? |
|
Definition
| 1) Vit. K deficiency, 2) Warfarin therapy, 3) Liver disease, 4) Factor VII deficiency |
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Term
| What factors may be affected if there is a normal PT but prolonged PTT? |
|
Definition
| Factors VIII, IX, XI, XII |
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Term
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Definition
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