Term
|
What are the Negative Symptoms of schizophrenia? |
|
Definition
lack of emotion
poor self care
reduced speech output
attention impairment |
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Term
What are the positive Symptoms of schizophrenia? |
|
Definition
Auditory hallucinations
Delusions |
|
|
Term
How is Schizophrenia diagnosed (American Psychiatric Ass.) |
|
Definition
Patients with 2 or more of the following:
- delusions
- halucinations
- disorganised speech
- catatonic behaviour
- negative symptoms |
|
|
Term
What are the typical antipsychotics? |
|
Definition
|
Phenothiazines: chlorpromazine, thiodazine, fluphenazine, trifluperazin
Butyrophenones: haloperidol, benperidol
Thioxanthenes: flupentixol
Benzamides: amisulpride |
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|
Term
What are the Atypical antipsychotics? |
|
Definition
Clozapine
Risperidone
Olazapine
Quetiapine |
|
|
Term
What was the traditional treatment for acute schizophrenia? |
|
Definition
Chlorpromazine po
Thioridazine po
Trifluoperazine po
Haloperidole im or iv |
|
|
Term
What drug may be given to counter the extrapyramidal effects of haloperidole? |
|
Definition
|
|
Term
What do more recent guidelines for the treament of acute schizophrenia recommend? |
|
Definition
Risperidone po
Quetiapine
Olanzapine |
|
|
Term
When should atypical be changed? |
|
Definition
IF unacceptable side-effects
or
IF no effect after 6-7 weeks |
|
|
Term
What drugs are given in relapse prevention of schizophrenia in patients with GOOD compliance?
(hospitalised etc) |
|
Definition
Trifluoperazine po
Haloperidole po
Thioridazine po
Risperidone po |
|
|
Term
What drugs are given in relapse prevention of schizophrenia in patients with POOR compliance |
|
Definition
depot agent:
Flupentixol decanoate
Haloperidole decanoate
Fluphenzine decanoate
Inj. risperidone or olanzapine |
|
|
Term
What are the cons associated with depot agents? |
|
Definition
May take several months to reach steady state.
Not always consistant plasma drug level
Variable side effects.
Extrapyramidal effects common. |
|
|
Term
Where is depot agent injected? |
|
Definition
deep, outer, upper quadrant of buttock |
|
|
Term
Summary of major side effects of antipsychotics? |
|
Definition
Extrapyramidal - dystonia, parkinson like symptoms, tardive dyskinesia
Postural hypotension
Photosensativity
Sedation
Anticholinergic |
|
|
Term
What antipsychotic may cause sunburn? |
|
Definition
|
|
Term
Which antipsychotic is associated with a reduction in visual acuity and impairment of night vision |
|
Definition
|
|
Term
Which antipsychotic is particularly associated with dystonic reactions and akathisia? |
|
Definition
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