Term
| Clinical Presentation: Ulcerative Colitis |
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Definition
- Rectal bleeding
- Tenesmus (incomplete evacuation)
- Diarrhea (bloody, mucopurulent, watery)
- Crampy abdominal pain
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Term
| Clinical Presentation: Crohn's Disease |
|
Definition
- Diarrhea (50% bloody)
- Crampy abdominal pain
- Perianal lesions
- Growth retardation
- Weight loss
- Fever Nausea
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Term
| Where do lesions predominate in Ulcerative Colitis? |
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Definition
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Term
| Nonpharmacological IBD Treatment |
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Definition
1. Nutrition Support
- Eliminate foods observed to exacerbate symptoms
- Parenteral nutrition support with active severe disease may be necessary
2. Surgery
- UC -- proctolectomy -- curative
- CD -- resection of damaged bowel sections, surgical fistula correction or abscess drainage -- non-curative
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Term
| Pharmacologic Therapy for IBD |
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Definition
1. Aminosalicylates
- Sulfasalazine
- Mesalamine
- Olsalazine
- Balsalazide
2. Antibiotics
- Metronidazole
- Ciprofloxacin
3. Corticosteroids
4. Immunomodulators
- Azathioprine
- 6-MP
- Methotrexate
- Cyclosporine
5. Biologic Response Modifiers
- Infliximab
- Adalimumab
- Certolizumab
- Natalizumab
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Term
| First line class of drugs for mild to moderate UC and Crohn's |
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Definition
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Term
| Site-Specific Pharmacotherapy: Colon |
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Definition
- Sulfasalazine derivatives
- Mesalamine derivatives
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Term
| Site-Specific Pharmacotherapy: Ileum |
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Definition
| Modified release mesalamine (pentasa, asacol) |
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Term
| Site-Specific Pharmacotherapy: Jejunum |
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Definition
| Modified release mesalamine (pentasa, asacol) |
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Term
| Site-Specific Pharmacotherapy: Duodenum and above |
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Definition
| May require systemic corticosteroids |
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