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the Glyoxylate cycle
glyoxylate cycle enzymes, reactions, substrates.
39
Biology
Undergraduate 1
05/01/2008

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Term
glyoxylate cycle
Definition

-modified version of the TCA cylce, made for plants and some microbes

-allows for bypass of decarboxylation rxns so no CO2 is lost

-allows plants to use fatty acids as Carbon for biosynthesis

Term
2 reactions unique to the glyoxylate cycle
Definition

Isocitrate lyase(cleaves isocitrate to yields succinate and glyoxylate)

Malate synthase( adds 2 Cs to glyoxylate to yield malate)

Term
location of the Glyoxylate cycle
Definition
glyoxysome
Term
location of the TCA cycle
Definition
Mitochondrion
Term
location of gluconeogenesis
Definition
cytosol( malate to glucose)
Term

true or false

Malate synthase is regulated by the action of a kinase.

Definition
false
Term

Contains a nicotinimide ring.

Diffuses in aqueous portions of the cell

Definition
NAD+
Term
Can contain one, two, or four irons.
Definition
iron sulfur center
Term
Cycles between Fe2+ and Fe3+.
Participates in the direct transfer of electrons without protons
Definition
Iron Sulfur center and heme
Term
Can carry either one or two electrons.
Definition
Ubiquinone (CoenzymeQ), FAD and FMN
Term
prochiral molecule
Definition
symmetric molecule that react asymmetricallly
-citrate
Term
unique intermediate of the glyoxylate cycle
Definition
glyoxylate
Term
outer membrane of the mitochondria
Definition
permeable to small molecules and ions
Term
matrix of the mitochondria
Definition
permeable to small molecules and ions
contains -PDH complex
-TCA cycle enzymes
-fatty acids beta oxidation enzymes
-aa oxidation enzymes
-soluble metabolic intermediates
-DNA ribosomes
Term
inner membrane of the mitochondria
Definition
contains respiratory electron carriers (complexes 1-4)
ADP ATP translocase
Term
amytal
Definition
Oxidized: Ubiquinone
Oxidized: Cua center in complex IV
reduced: Fe-S Centers in Complex 1
Oxidized: Cytochrome c1
Term
Antimycin A
Definition
Oxidized: Cytochrome c1
Reduced: Fe-S Centers in Complex 1
Reduced: Coenzyme Q
Oxidized: Cua center in complex IV
Term
Cyanide
Definition
Reduced: Coenzyme Q
Reduced: Cytochrome c1
Reduced: Cua center in complex IV
Reduced: FMN in Complex 1
Term
Oligomycin
Definition
Reduced: Cytochrome a
Reduced: FMN in Complex 1
Reduced: Coenzyme Q
Reduced: Cytochrome c
Term
FCCP
Definition
Cycling between oxidized and reduced: FMN in Complex 1
Cycling between oxidized and reduced: Cytochrome c
Cycling between oxidized and reduced: Coenzyme Q
Cycling between oxidized and reduced: Cytochrome a3
Term
most abundant protein on earth
Definition
RUBISCO
Ribulose 1,5 Bisphosphate carboxylase
ribulose + CO2 ---->3phosphoglycerate
Term
regulation of rubisco
Definition
light availability
active in the day
inactive at night
pH Mg+
Term
stage two of calvin cycle
Definition
reduction of coenzymes and synthesis of hexose
Term
stage three of calvin cycle
Definition
regeneration of rubisco
Term
only membrane bound enzyme in the TCA cycle
Definition
Succinate dehydrogenase
Term
NAD+-specic isocitrate dehydrogenase is a key regulatory enzyme of the citric acid cycle. It is regulated by
Definition
Ca 2+, activator and AMP, activator.
Term
Contains a benzoquinone ring
Definition
ubiquinone
Term
Participates in the direct transfer of electrons without protons.
Definition
iron sulfur center and heme
Term
Typically contain bonds between Fe ions and Cys residues in the protein.
Definition
iron sulfur center
Term
Typically a protein prosthetic group.
Definition
Iron-Sulfur Center, Heme, FAD and FMN
Term
Can carry either one or two electrons
Definition
Ubiquinone (CoenzymeQ), FAD and FMN
Term
F1
Definition
Contains the catalytic subunits for ATP synthase
Term
F0
Definition
Contains the protein that confers oligomycin sensitivity
Term
structure linking F1 and F0
Definition
Contains the protein that confers oligomycin sensitivity
Term
FCCP,dinitrophenol

Definition
Uncoupling of electron transport and oxidative phosphorylation.
Term
amytal, rotenol
Definition
Inhibition of NADH - Q Reductase (complex I).
Term
CN-, CO
Definition
Blocks electron flow in cytochrome oxidase (complex IV)
Term
atractyloside
Definition
Inhibition of ADP-ATP translocase
Term
respiratory coupling or control
Definition
Regulation of electron transport by ADP availability
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