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The Cell Cycle
Biology 1201: Chapter 12
46
Biology
Undergraduate 1
10/21/2012

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Term
Cell Division
Definition
The reproduction of cells
Term
Cell Cycle
Definition

An ordered sequence of events in the life of a cell

 

Term
Genome
Definition
Total DNA content of a cell or organelle.
Term
Chromosome
Definition
Condensed chromatin
Term
Chromatin
Definition
DNA in a complex with proteins
Term
Somatic Cells
Definition
Body cells
Term
Gametes
Definition
Sex or reproductive cells
Term
Sister Chromatids
Definition
Two copies of replicated chromosomes held together by a centromere
Term
Centromere
Definition
A region containing specific DNA sequences where the chromatid is attached most closely to its sister chromatid
Term
Mitosis
Definition
The division of the genetic material in the nucleus
Term
Cytokinesis
Definition
The division of the cytoplasm
Term
Mitotic Spindle
Definition
Begin to form in the cytoplasm during prophase
Term
Centrosome
Definition
The microtubule organizing centers
Term
Aster
Definition
A radical array of short microtubules
Term
Kinectochore
Definition
A structure of proteins associated with speficif sections of chromosomal DNA at each centromere
Term
 Metaphase Plate
Definition

An imaginary structure located at a plane midway between the two poles of a cell in metaphase on which the centromeres of all the duplicated chromosomes are located

 

Term
Cleavage
Definition
Cytokinesis in eukaryotic cells
Term
Cleavage Furrow
Definition
A shallow in the cell surface near the old metaphase plate
Term
Cell Plate
Definition
A memebrane-bounded, flattened sac located at the midline of a dividing plant cell, inside which the new cell wall forms during cytokinesis
Term
Binary Fission
Definition
A method of asexual reproduction
Term
Origin of Replication
Definition
 Site where the replication of a DNA molecule begins
Term
Cell Cycle Control System
Definition
A cyclically operating set of molecules in the cell that both triggers and coordinates key events inthe cell cycle
Term
Checkpoint
Definition
The control point where stop and go-ahead signals can regulate the cycle
Term
G0 Phase
Definition
A nondividing state occupied by cells that have left the cell cycle, somethimes reversibily
Term
Cyclin
Definition
A protein that gets its name from its cycally fluctuating concentration in the growing cell
Term
Cyclin-Dependent Kinases (Cdks)
Definition
A protein kinase that is active only when attached to a particular cyclin
Term
MPF
Definition
The cyclin-Cdk complex that was discovered first (in frog eggs)
Term
Growth Factor
Definition
A protein released by certain cells that stimulates other cells to divide
Term
Density-Dependent Inhibition
Definition
A phenomenon in which crowded cells stop dividing
Term
Anchorage Dependence
Definition
The requirement that a cell must be attacked to a substratum in order to initiate cell division
Term
Transformation
Definition
The process that converts a normal cell to a cancer cell
Term
Benign Tumor
Definition
Nonlife threatening tumor
Term
Malignant Tumor
Definition
Cells whose genetic and cellular changes enable them to spread to new tissues and impair the functions of one or more organs
Term
[image]
Definition
Anaphase
Term
[image]
Definition
G2 of Interphase
Term
[image]
Definition
Metaphase
Term
[image]
Definition
Prometaphase
Term
[image]
Definition
Prophase
Term
[image]
Definition
Telophase and Cytokinesis
Term
G2 of Interphase
Definition

 

  • A nuclear envelope encloses the nucleus
  • The nucleus contains 1+ nucleoli
  • 2 centrosomes have formed by duplication of a single centrosomes
    • Centrosomes: regions in animals cells that organize the microtubules of the spindle
    • Each centrosome contains two centrioles
  • Chromosomes, duplicated during S Phase

 

Term
Prophase
Definition
  • The chromatin fibers becomes more tightly coiled
  • The nucleoli disappear
  • Each duplicated chromosome appears as 2 sister chromatids joined at their centromeres
  • The miotic spindle begins to form
    • Composed of: centrosomes and microtubules
  • Microtubules extend from centrosomes called asters
  • Centrosomes move away from themselves
Term
Prometaphase
Definition
  • The nuclear envelope fragments
  • The microtubules extending from each centrosomes can now invade the nuclear area
  • Chromosomes are even more condensed
  • Each of the two chromatids of each chromosomes has a kinetochore
  • Microtubules attach to the kinetochore which cause a push and pull with the chromosomes
  • Nonkinetochore microtubules interact with those from the opposite pole of the spindle
Term
Metaphase
Definition
  • Centromeres are opposite of the cell
  • Chromosomes convene at the metaphase plate
  • Chromosomes' centromeres are at the metaphase plate
  • For each chromosome, te kinetochores of the sister chromatids are attached to kinetochore microtubules coming from opposite poles
Term
Anaphase
Definition
  • Shortest phase state of mitosis
  • Begins when the cohesin proteins are cleaved
  • Allows the two sister chromatids of each pair to part suddenly
  • Each chromatid thus becomes a full-fledged chromosome
  • Chromosomes begin moving towards opposite ends of the cell
  • Kinetochore microtubules shorten
  • Cell elongates and nonkinetochore microtubules lengthen
Term
Telophase
Definition
  • 2 daughter nuclei form
  • Nuclear envelopes arise from fragments of parent's nuclear envelope
  • Nucleoli reappear
  • Chromosomes become less condensed
  • Remaining spindle microtubules are depolymerized
  • Mitosis is now complete
Term
Cytokinesis
Definition
  • The division of the cytoplasm is usually well under way by late telophase, so the two daughter cells appear shortly after the end of mitosis
  • In animal cells, cytokinesis involves the formation of a cleavage furrow, which pinches the cell in two.
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