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Test #4 Chapters 28-40
Vaccines
15
Pharmacology
Undergraduate 2
03/27/2011

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Cards

Term
Active immunity
Definition
-body makes antibodies (immunoglobulins) in response to bacteria or virus
Term
Acquired immunity
Definition
-exposure to antigen or by passive injection of immunoglobulins (vaccine)
Term
Natural immunity
Definition
-geneticall determined in specific populations
Term
Vaccination
Definition

-administering small amount of antigen

-stiumlate immune response

-does not give disease

-inactivated, attenuated, toxoid, conjugate, recombinant subunit

Term
Inactivated vaccine
Definition
-whole or part of killed microorganism
Term
Attenuated vaccine
Definition
-live, weakened microorganism
Term
Toxoid
Definition
-inactivated toxins, disease-producing substance produced by microorganism
Term
Conjugate vaccine
Definition
protein or toxoid from unrelated microorganism that links to the outer coat of disease-causing microorganism, creating a substance that is recognized by immature immune system (infants-Haemophilus influenza B)
Term
Recombinant subunit vaccine
Definition
-insert some of the genetic material (DNA) of a pathogen into another cell/organism, producing antigens; antigens then used as vaccine in place of the whole pathogen (Hepatitis B)
Term
Passive Immunity
Definition

-person receives antibodies against a particular pathogen from another source (newborn infant recieves maternal antibodies via placenta), (administration of antibodies)

-short-lived (weeks-months, then no longer present)

-no immune response experienced

-used if own immune response incapable of producing effective immune response

-exposed person at high risk of complications from exposure

-used when time does not permit active vaccination

Term
Childhood immunizations
Definition

-check prescription, OTC use

-food & drug allergies

Term
Adult immunizations
Definition
-Tetanus
Term
Foreign travel immunizations
Definition

-typhoid

-yellow fever

-specific to travel area

Term
Reporting Adverse Reactions to Vaccines
Definition

-chart lot# when vaccination given

-adverse reaction reported to VEARS (Vaccine Event Adverse Reporting System)

Term
*Varicella (Varivax)
Definition

-vaccine for chicken pox

-may provide prophylaxis w/ exposure or 3-5 days

-dose: 0.5 ml SQ, 2 doses (1st @ 12-15 months, 2nd @ 4-6 yr)

SE: injection site reaction, fever, chickenpox-like rash (mild)

-Adverse: encephalitis, Steven-Johnson syndrome, thrombocytopenia, anaphylaxis

CI: immune-compromised, pregnancy or possibility of, active/untreated TB, moderate-severe illness

-drug-drug: No salicylates for 6 wk (Reye syndrome), no high dose steroids, no vaccine for 5 months if transfusion or immune globulins

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