Term
| HAART (Highly active antiretroviral therapy) |
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Definition
-combination therapy
-NRTI (nucleotide reverse transcriptse inhibitors
-NNRTI (nonnucleotide reverse transcriptase inhibitor
-PI (protease inhibitor)
-drug resistance is a challenge |
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Term
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Definition
- decreases viral load to undetectable
-stabilizes or increases # of CD 4 + T cells
-reduce incidence of opportunistic infections
-minimize SE of antiviral therapy
-improve quality of life, survival |
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Term
| NRTI (nucleotide reverse transcriptase inhibitors) |
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Definition
-block viral
-SE: hepatic steatosis (fatty)
-lipoatrophy, peripheral neuropathy, pancreatitis, lactic acidosis, n/v/d can last 2 wk |
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Term
| *Zidovudine (Retrovir, AZT) |
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Definition
-NRTI, treat HIV & prevent maternal-fetal HIV transmission
-$6500/yr
-dose: 200 mg po
-SE: neuropathy, rash, pruritis, insomnia, confusion, bluish-brown bands on nails
-Adverse: anemia, neutropenia, seizures
-watch renal/hepatic issues |
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Term
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Definition
NRTI, HIV drug
-take on empty stomach |
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Term
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Definition
-NRTI, HIV drug
-30-40 mg |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| NNRTI (Non-nucleotide reverse transcriptase inhibitors) |
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Definition
-prevent viral replication
-drug resistance is a challenge |
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Term
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Definition
-NNRTI, HIV drug
-$7725/yr
-dose: 600 mg at bedtime, increased absorption w/ high-fat meal
-SE: dizzy, sedation, loss of concentration, nightmares, diarrhea
-Adverse: convulsion, suicide, aggression, liver failure, neuropathy |
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Term
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Definition
-NNRTI, HIV drug
-dose: 200 mg
SE: rash, hepatotoxic, Steven-Johnson syndrome |
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Term
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Definition
-act at end of HIV cycle to block production of HIV viruses
-improved sustained viral response, improved survival |
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Term
| *Lopinavir/ritonavir (Kaletra) |
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Definition
-PI, HIV drug
-$11,000/yr
-dose: 400 mg w/ food
-SE: n/v/d, hyperglycemia
-Adverse: DM
-caution if hx of pancreatitis
-drug-drug: azole antifungals, statins, St. John's wort |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
-entry inhibitor, HIV drug
-expensive
-dose: 90 mg SQ
SE: rash, diarrhea, injection site reaction |
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Term
| HIV/AIDS drugs Nursing Measures |
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Definition
-asses for weight loss, chronic diarrhea
-assess for immune suppression ie opportunistic infections (fever, malaise, thrush)
-give emotional support
-educate on transmission of virus
-monitor adherence to med regimen
-assess labs (CBC, CD4 counts)
-hand washing |
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