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Test 4 2007
Micro Test #4
65
Biology
Not Applicable
04/30/2007

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Term
acyclovir
Definition
a chemical mutagen that repalces guanine used in treatment of herpes virus
Term
vidarabine
Definition
a chemical mutagen that prevents formation of phos. Di backbone
Term
AZT
Definition
chemical mutagen that repalces T used in AIDS treatment
Term
nucleotide base analogues
Definition
chemical mutagen that prevents formation of intact DNA molecules
Term
transformation
Definition
uptake and insertion of “naked” DNA
Term
conjugation
Definition
mating and exchange of DNA by mating types
Term
transduction
Definition
DNA is carried by a virus from one cell to another
Term
Transformation
Definition
first discovered by Griffith studies of S. pneumoniae in 1929. Studied Smooth cells that have capsule. rough colonies lack capsule (not pathogenic)
Term
Conjugation
Definition
exchange of genetic material b/w mating types.

involves transer of plasmid DNA
Term
Fertility factors
Definition
transfer nuclear DNA
Term
R factors
Definition
(type of plasmid)

antibiotic resistant, encode for enzymes
Term
Col plasmids
Definition
(type of plasmid)

encode for killer proteins
Term
pili
Definition
organism of sex (in plasmids)
Term
episomes
Definition
plasmids that insert into nuclear DNA
Term
transposons
Definition
"jumping genes"

genes taht exchange places within a DNA molecule or move from one molecule to another
Term
B. McClintock
Definition
transposons were first studied by?
Term
plasmids
Definition
used as vectors to introduce foreign genes into bacteria ("gen. engineered")
Term
insulin
Definition
peptide hormone w/ a known AA sequence
Term
virual capsid
Definition
protein coat, protects teh N.acid functions in the recognition of teh virus. can be tissue specific
Term
organotropism
Definition
tissue specificity of a virus
Term
dermatotrophic
Definition
skin infecting virus
Term
viserotrophic
Definition
internal organ viral infector
Term
neurotrophic
Definition
CNS viral infector
Term
enterotrophic
Definition
intestinal viral infector (polio)
Term
pneumotrophic
Definition
respiratory tract viral infector
Term
Helical viruses
Definition
rod-shaped; the nucleic acid is surrounded by protein subunits called capsomeres that make up the capsid
Term
polyhedral viruses
Definition
capsid (made up of capsidmeres) forms an icosahedron or a 20-sided figure; example is the polio virus
Term
enveloped virus
Definition
a virus that contains a lipid bilayer, contains spikes
Term
hemagglutinin
Definition
attaches to red blood cells and causes them to agglutinate
Term
neuraminidase
Definition
an enzyme that attaches to neuraminic acid associated with respiratory cells; the enzyme destroys th
Term
bacteriophage
Definition
combo of helical and polyhedreal viruses. discovered by Twort and d'Herelle
Term
lysis or genetics alteration of host cell
Definition
what are the 2 viral infection outcomes
Term
eclipse period
Definition
the period during which virions are being assembled
Term
1 in a million
Definition
possibility that a single mutation will occur during DNA replication?
Term
1 in a trillion!
Definition
possibility that a double mutation will occur in unlinked genes
Term
reversion
Definition
can correct a initial mutation
Term
lysogenic virus
Definition
a type of virus that can alter the genetic potential of a host cell in the lysogenic conversion of a cell
Term
latent viruses
Definition
lysogenic viruses that infect animal cells

|examples|

herpes virus
Term
polio virus & rabies
Definition
examples of RNA virus
Term
AIDS
Definition
retro virus, HTLV, attacks T-helper cells
Term
herpes type I
Definition
type of latent virus that infects facial nerves, causes fever blisters
Term
latent virus
Definition
lysogenic viruses that infect animal cells (can reoccur over time) they are permanent genetic residents
Term
herpes type II
Definition
type of latent virus that infects facial nerve cells in the urogenital system (genital herpes)
Term
herpes zoster
Definition
typy of herpes that causes chicken pox in children (shingles in adults)
Term
1. latent
2. transforming
3. RNA Viruses
Definition
name the 3 types of viruses
Term
transforming virus
Definition
when an animal virus infect a cell and the transform it into a oncogenic cell
Term
apoptosis
Definition
normal cells undergo a genetically determined number of cell divisions after which the cells die

** CANCER CELLS ARE IMMORTAL
Term
Epstein-Barr virus (mono)
Definition
virus that causes swollen lymph nodes. becomes lysogenic or latent in throat cells and distributed in teh saliva and blood
Term
DNA virus
Definition
this virus uses RNA as their genetic material

example are polio and RV
Term
RNA virus
Definition
these virus have RNA as their genetic material,

examples polio virus RV
Term
special case of RNA virus
Definition
-Retro viruses- (type of transforming virus)

have reverse transtase. which copies DNA from the RNA virus

the virus that caues AIDS is a retro virus
Term
DNA
Definition
most viruses that cause human cancers are DNA or RNA?
Term
proto-oncogenes
Definition
normal cells that carry out normal cell functions such as cell division and apotosis
Term
inhibitor of viral uncoating
Definition
amantadine
Term
inhibitor of viral polymerases
Definition
foscamet
Term
inhibitor of reverse transcriptase
Definition
nevirapine
Term
stem cells in the bone marrow
Definition
where are immune system cells derived from?
Term
cell response to destruction of a viron
Definition
1. macrophages engulf and destroy the virion (preserved on surface of the macrophage)

2. T-killer lymphocytes interact with the infected macrophages to remove it

3. this interaction stimulates rapid division of the T-killer lymphocytes (then, move into lymphatic and vascular system and seek out and kill infected virus)

4. some of the are retained as memory to remember any subsequent virus infection in the future
Term
humoral response (antibodies)
Definition
too long and i dont' feel like typing it out. hhaha
Term
how does the flu virus avoid attacks from the immune system?
Definition
viral spikes!

these puppies can change (mutate) so that teh immune sys must begin a brand new response to teh mutated virus

** required time and extensive cell division

this is called ANTIGENIC DRIFT
Term
antigenic shift
Definition
the ability of a host to be infected with two different strains of flu virus simultaneously
Term
viroids
Definition
"naked" RNA molecules that cause viral-like symptoms in PLANTS
Term
prions
Definition
infectious protein particles
Term
a-helix
Definition
a normal brain protein occurs in the form?

1. B-sheet
or
2. a-helix

this is a virus like disease that can destroy brain cells and cause a loss of motor functions and severe wasting
Term
Kuru
Definition
disease from Prions that occurs in New Guinea natives (women get it from diseased dead women)
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