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test 1
overview, chemistry, and cells
279
Physiology
Undergraduate 1
02/03/2008

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Cards

Term
Anatomy
Definition
The study of the structure and relationships of the parts of the body *Concrete Science
Term
Gross Anatomy
Definition
Study of large body structures visible to the naked eye (can be viewed 3 different ways)
Term
Regional anatomy
Definition
All structures in one part of the body (ex: muscles, bones, blood vessels, nerves, etc. in the abdomen or leg)
Term

Systemic anatomy

Definition
Gross anatomy studied by systems (ex: cardiovascular, digestive)
Term
Surface anatomy
Definition
Internal structures as they relate to overlying skin (ex: feel pulse, identify muscles)
Term
Microscopic Anatomy                -ology =“study of”
Definition
Study of structure too small to be seen with naked eye
Term
Cytology
Definition
 study of the cells
Term

Histology

Definition
study of the tissues
Term
Developmental Anatomy
Definition
Traces structural changes throughout the body (including before birth)
Term
Embryology
Definition
study of developmental changes before birth
Term
Specialized branches of anatomy
Definition
pathology, radiology, and molecular anatomy
Term
Pathology
Definition
Study of structural changes caused by disease (ex: tumor , pus, hemorrhage, hypertrophy)
Term
Radiology
Definition
Study of internal structures by x-ray or scan (looking at: density, abnormalities, fractures, diseases)
Term
Molecular anatomy
Definition
Study of anatomical structures at a subcellular level (what cell is composed of: nucleic acid, proteins, carbs, fats, inorganic molecules)
Term

Physiology

Definition
Study of the function of the body parts
Term
Physiology relies on physics principles
Definition
Movement of ions- currentMuscles and bone movement- levers
Term
Principle of complementarity of structure and function
Definition
Function is a reflection of structure[image]      Bones; support and protect due to hardness[image]      Muscles; move due to contractile proteins
Term
Levels of organization
Definition
Chemical, cellular, tissue, organ, organ system, organism
Term
Chemical level
Definition
Atoms form molecules
Term
Cellular level
Definition
Molecules are organized into cells
Term
Tissue level
Definition
Similar cell types form a tissue
Term
Organ level
Definition
Tissues combined to form organs
Term
Organ system level
Definition
Different organs working together
Term
Organismal level
Definition
Total result of combined organ systems
Term
Necessary Life Functions
Definition
Maintaining boundaries, movement, responsiveness, digestion, metabolism, excretion, reproduction, growth
Term
Maintaining boundaries
Definition
Separate external and internal environmentCellular level- plasma membraneOrganism level- integumentary system (skin)
Term
Movement
Definition
Locomotion, peristalsis (tubes), contractility (muscle tissue)
Term
Responsiveness
Definition
Sense and respond to changes in the environment
Term
Digestion
Definition
Extract nutrients from the environment
Term
Metabolism
Definition
All the chemical reactions in the body. After digestion, the breaking down of food into the smallest component possible.
Term
Catabolism
Definition
process in which living cells break down into simpler substances
Term
Anabolism
Definition
energy-requiring building phase of metabolism in which simpler substances are combined to form more complex substances
Term
Excretion
Definition
Elimination of waste product
Term
Reproduction
Definition
Cellular- for body growth or repairOrganismal- creating a new person (reproduction system)
Term
Growth
Definition
Increase in size of a cell, body part, or organism
Term
Survival needs
Definition
Nutrients, oxygen, water, maintenance of body temperature, atmospheric pressure(All factors should be present in appropriate amounts to support life)
Term
Nutrients
Definition
Obtained from plants and animal sources                Carbs and fats- fuel                Proteins and fats- build cell structures                Minerals and vitamins- reactions, oxygen                 transport, bone structure, bone clotting
Term
Oxygen
Definition
Obtained from air                Oxidative reactions- to use nutrients
Term
Water
Definition
Obtained from food and liquids. 60-80% of body weight. Base for chemical reaction, base for body secretions(hormone) and excretion (urine)
Term
Maintenance of body temperature
Definition
98.6°F or 37°CDecrease- metabolism slowsIncrease- reaction rate increases, proteins denature, reaction stops
Term
Atmospheric pressure
Definition
Force being exerted on body surface, impactsBreathing air in and out of lungsGas exchange between lungs and blood
Term
Homeostasis
Definition
The ability to maintain a relatively stable internal environment even with changing external environment. Stable not static (not changing)
Term
Internal environment is in…
Definition
Dynamic equilibrium (balance)
Term
All organ systems work together to stay balanced
Definition
CVS- carries O₂ and CO₂Digestive system- provides nutrients to blood and           removes wasteUrinary system- removes wastePulmonary system- exchanges gases
Term
Stimulus
Definition
Change or something that causes environment to change
Term
Variable (factor or event being regulated)3 components
Definition
receptor, control center, effector
Term
Receptor
Definition
monitors environment, detects change, and sends information (input to the control center) along afferent pathway
Term
Control center
Definition
determines the set point (the level or range at which a variable is to be maintained) and determines response and sends output along efferent pathway
Term
Effector
Definition
provides a means o response to the change
Term
integumentary system
Definition
forms the external body covering; protects deeper tissues from injury; synthesizes vitamin D; site of cutaneous (pain, pressure, etc.) receptors, and sweat and oil glands
Term
skeletal system
Definition
protects and supports body organs; provides a framework the muscles use to cause movement; blood cells are formed within bones, stores minerals
Term
muscular system
Definition
allows manipulation of the environment, locomotion, and facial expression; maintains posture; produces heat
Term
lymphatic system/ immunity
Definition
picks up fluid leaked from blood vessels and returns it to blood; deposes of debris in the lymphatic stream; houses white blood cells (lymphocytes) involved in immunity. The imune response mounts the attack against foreign substances within the body
Term
respiratory system
Definition
keeps blood constantly supplied with oxygen and removes carbon dioxide; the gaseous exchanges occur through the walls of the air sacs of the lungs
Term
digestive system
Definition
breaks down food into absorbable units that enter the blood for distribution to body cells; indigestible foodstuffs are eliminated as feces
Term
nervous system
Definition
fast-acting control system of the body; responds to internal and external changes by activating appropriate muscles and glands
Term
endocrine system
Definition
glands secrete hormones that regulate processes such as growth, reproduction, and nutrients use (metabolism) by body cells
Term
cardiovascular system
Definition
blood vessels transport blood which carries oxygen, carbon dioxide, nutrients, waste, etc.; the heart pumps blood
Term
urinary system
Definition
eliminates nitrogenous waste from the body; regulates water, electrolyte and aicd-base balance of the blood
Term
male and female reproductive systems
Definition
overall function i production of offspring. testes produce sperm and male sex hormone; ducts and glands aid in delivery of sperm to the female reproductive tract. ovaries produce eggs and female sex hormones; remaining structures serve as sites for fertilization and development of the fetus. mammary glands of female breasts produce milk to nourish the newborn
Term
Matter
Definition
Occupies space and has mass
Term
Mass
Definition
Remains constant
Term
States of matter
Definition
1.       Solid- has volume and shape2.       Liquid-  has volume and assumes shape of container3.       Gas- no definite shape or volume
Term
Energy
Definition
The capacity to do work.[image]      Measured by its effect on matter[image]      Has no mass and takes up no space
Term
Kinetic energy
Definition
Energy in motion
Term
Potential energy
Definition
Stored energy or energy of position
Term
Kinetic and potential energy
Definition
Can be converted each into the other forms of energy
Term
Chemical energy
Definition
The energy stored in chemical bonds
Term
Electrical energy
Definition
Results from the movement of charged particles. In the body, electrical charges exist as ions.
Term
Mechanical Energy
Definition
Directly involving moving matter
Term
Electromagnetic or radiant energy
Definition
Travels in waves (heat, light x-ray, microwave, etc.)
Term
Composition of matter
Definition
atoms and elements
Term
Elements
Definition
[image]      All matter is composed of elements[image]      These are substances that cannot be broken down into other components by ordinary chemical means
Term
Atoms
Definition
[image]      The smallest particle to maintain the properties of an element[image]      Made up of protons, neutrons and electrons
Term
Nucleus
Definition
central core of an atom made up of protons and neutrons
Term
Proton
Definition
a particle with a positive (+) charge
Term
Neutron
Definition
a particle with no (0) charge
Term
Protons and neutrons
Definition
Each have the same approximate mass (1 amu)
Term
Atomic number
Definition
number of protons dictates the identity of the element
Term
Atomic mass
Definition
number of protons added to the number of neutrons
Term
Isotopes
Definition

Atoms of an element that have differing amu because of different numbers of neutrons.

Example:

Carbon12 g 6 protons  6 neutronsCarbon13 g 6 protons  7 neutronsCarbon14 g 6 protons  8 neutrons
Term
Electrons
Definition
particles that carry a negative (-) charge that is equal in strength to the positive (+) charge of a proton[image]      Mass is negligible:  given an amu of 0[image]      Electrical balance: number of electrons equals the number of protons, so atoms are electrically neutral
Term
Models of atomic structure
Definition

Planetary model and orbital model (e-cloud)

                Know the difference
Term
Electron shell
Definition

Region occupied by e-clouds represent different energy levels. each shell holds a specific number of e-

Term
Chemical Bonds
Definition
1.       Chemical bonds involve sharing or transfer of e-2.       Only e- in the outermost shell participate in bonding.3.       Reactive elements have an unfilled outermost shell
Term
Atomic stability
Definition
is achieved when the outermost shell is full or has 8e-Atoms with a full outer shell are chemically inert
Term
Octet rule
Definition
Except for shell #1, atoms react in such a way as to obtain 8e- in their outermost shell The number of e- that can participate in bonding is limited to 8
Term
Valence shell
Definition
The outermost shell containing reactive e-
Term
Types of chemical bonds
Definition
1.       Ionic2.       Covalent3.       Hydrogen bonds
Term
Anion
Definition
The atom that gains e- attains a net (-) charge
Term
Cation
Definition
The atom that loses e- attains a net (+) charge
Term
Ionic bonds
Definition
The transfer of e- from one atom to another
Term
Formation of an ionic bond
Definition
Because the atoms have opposite charges, they are held in association with each other, resulting compound is called a salt, exists in the form of crystals rather than individual molecules. Most ionic bonds form between atoms with one or two valence e- and atoms with 7 valence e-. (i.e. metals and halogen)
Term
Covalent bonds
Definition
The sharing of pairs of e-. the shared e- occupy an orbital shared by both atoms
Term
Single covalent bonds
Definition
One pair of shared e-Examples:nHydrogen
H + H
® H2           (H-H)nCarbon + 4 Hydrogen 
C + 4H
® CH4 
Term
Double covalent bonds
Definition
Two pairs of shared e-Examples:nOxygen                                                                                               O + O ® O2            (O = O)nCarbon + 2 Oxygen
C +  2O
®  CO2                  (O = C = O) 
Term
Triple covalent bonds
Definition

Three pairs of shared e-

Examples:

Nitrogen
N + N
® N2        (N º N)
Term
Polarity is a result of…
Definition
The shape of a molecule and a characteristic of uneven electron sharing
Term
Covalent bonded molecules may be…
Definition
Polar of non-polar
Term
Non-polar molecules
Definition
Are electrically balanced and do not have (+) and   (-) poles
Term
Polar molecules
Definition
Have areas that are relatively more (+) or (-) charged. Often these molecules are asymmetrical
Term
Electronegative
Definition
An atom that is e- hungry, usually a small atom with 6 or 7 valence e-
Term
Electropositive
Definition
An atom with low e- attraction, usually 1 or 2 valence e-
Term
Hydrogen bonds
Definition
A function of polarity. H already covalently bound in a polar molecule as attracted to an electronegative atom (usually O or N).
Term
Hydrogen bonds are
Definition
1.       Responsible for the surface tension of water2.       Weaker than ionic and covalent bonds3.       More of an attraction or tendency than a true bond*IMPORTANT: Hydrogen bonds are responsible for many intra-molecular bonds that give molecules their specific shape.
Term
Chemical reactions  H  +  H  ®  H2Reactants         Products                            Subscript number = bonded atoms C  +  4H  ®  CH4     molecular formulaPrefix number = unjoined atoms
Definition
Occur when chemical bonds are formed, broken or rearranged
Term

Molecule

Definition
The formation of a chemical bond between 2 atoms forms a molecule
Term
Elemental molecule
Definition

A molecule formed by 2 atoms of the same element

H₂ = hydrogen molecule
Term
Compound
Definition

A molecule formed by bonding unlike elements

CH₄ = methane molecule
Term
Three basic types of mixtures
Definition
Solutions, colloids, and suspensions
Term
Solutions
Definition
A homogenous mixture (solid, liquid, or gas)
Term
Solvent
Definition
The component of a solution present in the great amount (ex: water)
Term
Solute
Definition
The component present in the smaller amount (ex: salt)
Term
Colloid (also called an emulsion)
Definition
[image]      Larger particles (heterogeneous )do not settle out[image]      Usually hazy in appearance (i.e. jello, intracellular fluid)
Term
Suspension (heterogeneous)
Definition
Large particles that tend to settle out (i.e. sand in water or blood)
Term
Concentration
Definition
Describes the amount o solute in a solution
Term
Percent concentration
Definition
Amount of solute per 100 parts solution (i.e. 3g of NaCl in 100cc = 3g% solution)
Term
Molarity
Definition
A description of concentration based on metric calculations[image]      Based on the atomic weight or molecular weight (combined atomic weights in a molecule)[image]      Mole: the atomic weight (or molecular weight) expressed in grams
Term

Avogadro’s number

6.02 X 10²³
Definition
A mole of a substance contains a fixed number of particles (atoms or molecules)
Term

Synthesis or combination reaction

 (Anabolic)
Definition
Involves bond formation; construction
Term

Decomposition reaction

(Catabolic)
Definition
The breaking of bonds; a degradation or deconstructive process
Term
Exchange or displacement reaction
Definition
Combines synthesis and decomposition; reactions change partners or proportions
Term

Oxidation/Reduction reaction

(Also called Redox)
Definition
A decomposition reaction in which e- are exchanged between reactionsOxidation: the e- donor is oxidizedReduction: the e- recipient is reduced(in some cases the e- is not completely exchanged but the e- sharing is altered in covalent bonds)
Term
Energy flow (reactions classified on consumption or release of energy)
Definition
Exergonic reaction: release energy, provide energy that can be used, products have less energy than reactants, catabolic or oxidativeEndergonic reaction: absorb energy, products contain more potential energy than reactants, typically anabolic reactions
Term
Reversibility of chemical reactions
Definition
All reactions are theoretically capable of running either way (reversibility)           
Term
Chemical equilibrium
Definition
Once the reaction reaches a “steady state” (no changes in amounts of reactants or products)
Term
Biochemistry
Definition
The chemical composition and reactions of living matter
Term
Compounds are classified as…
Definition
Organic (containing carbon except for CO₂) and inorganic (water, salts, no carbon)
Term
Inorganic compounds
Definition
Water, salts, Acids and bases
Term
Organic compounds
Definition
Carbohydrates, lipids (fats), and proteins
Term
proerties that make water vital
Definition

high heat capacity, high heat of vaporization, polar solvent properties, cushioning, and reactivity

Term
water's high heat capacity
Definition
relatively resistant to changes in temperature by internal or external means, redistributes heat in body
Term
water's high heat of vaporization
Definition
large amount of heat is required to break hdrogen bonds... important to sweat
Term
water's polar solvent properties
Definition
because of water's polaritty, ionic compunds dissociate in water; water forms hydration layers around large charged molecule (ie proteins); as a solvent water is the transport medium for nutrients, gases and metabolic products/wastes
Term
water's reactivity
Definition

hydrolysis- addind an H2O molecule to a molecular bond to break the bond

dehydration synthesis- extracting as H2O molecule to form a molecular bond

Term
water's cushioning
Definition
in membranes around body organs (ex: fluid around brain)
Term
electrolytes
Definition
all ions are electrolytes in that they carry electric current in solution
Term
acids
Definition

(proton donors) release H+ ions

Term
bases
Definition
(proton acceptors) hydroxides release OH- in a solution. * other significant bases: HCO3- and NH3
Term

pH: acid/base concentration

ph= -log[H+]

Definition

aicdic: pH 0-6.99

neutral: pH 7

bascic: pH 7.01-14

Term
pH of blood
Definition
7.35-7.45
Term
neutralization reaction
Definition
mixture of acid and base, forming water and salt
Term
buffers
Definition
resist abrupt changes in pH; accept H+ in an acid solution; release H+ in a basic solution
Term
buffers are weak acids and bases
Definition
dissociate slow
Term
strong aicds and bases
Definition
dissociate fast
Term
organic compounds
Definition
(all carbon containing) carbohydrates, lipids, proteins, and nucleic acids *in all living cells
Term
carbohydrate
Definition
organic compound composed of hydrogen, carbon, and oxygen; includes starches, sugars, cellulose
Term
isomers
Definition
molecules with the same chemical formulas but different arrangement of the atoms and thus different chemical properties
Term
disaccharides
Definition
two monosaccharides jioned by dehydration synthesis
Term
polysaccharides
Definition
long chains of linked monosaccharides. relatively starch (storage CHO of plants) and glycogen (storage CHO of animals)
Term
starch and glycogen differ...
Definition
in the degree of branching
Term
polymers
Definition
chainlike molecules made of many similar units
Term
carbohydate funtions
Definition
redox reactions- glucose molecules are broken and release energy that is used to form ATP; When ATP supplies areadequate glucose is stored as glycogen and fat (some CHO are structural like in DNA, in RNA and sugars in cell membranes)
Term
lipids (fats)
Definition
neutral fats, phospholipids, and steriods. all contain C, H, and O with
O in smaller proportions than in carbohydrates
Term

neutral fats (triglycerides)

Definition

3fatty acids + 1glyerol

formed by dehydration synthesis

Term
glycerol
Definition
a modified simple sugar
Term
saturated chains...
Definition
...tend to form solids. only single covalent bonds between carbon atoms C-C
Term
unsaturated chains...
Definition

...tend to be liquid. one or more double covalent bonds between carbon atoms C=C

Term
phospholipids
Definition
modified triglycerides glycerol with 2 fatty acid chains (nonpolar) and one phosphorus containing group (polar)
Term
amphipathic molecules
Definition
have both polar and nonpolar regions
Term
steriods
Definition
a lipid with the structure of four interlocking rings
Term
cholesterol
Definition
dietary form of steroid and basic steriod in the body; source molecule for steriod hormones, vitamin D, bile, salts, and cell membranes
Term
eicosanoids
Definition

diverse lipids chiefly derived from a 20-carbon fatty acid (arachidonic acid) found in all cell membranes

*prostaglandins; important in blood clotting, inflammation, and labor contractions

Term
proteins
Definition
amino aicds linked by peptide bonds (20 different amio aicds occur commonly)
Term
amino acids contain...
Definition
an amine group(-NH2), a carboxyl group(-COOH), and a variable R group
Term
peptide bonds
Definition

bond joining the amine group of one amino acid to the acid carboxyl group of a second amino acid with the loss of a water molecule

 

2AA = dipeptide

3AA = tripeptide

10 or more AA = polypeptide

50AA = protein

Term
macromolecules
Definition
large, complex molecules containing from 100 to 10,000 amino acids
Term
primary protein structure
Definition
structure resembles strand of amino acid "beads", is the backbone of the protein molecule
Term
secondary protein structure
Definition

alpha helix- coiled

beta pleated sheet- folded in pleats

Term
tertiary protein structure
Definition
secondary struces folded together
Term
quaternary structure
Definition

two or more polypeptide chains aggregrate in a regular manner to form a complex protein

Term

fibrous protein

(structural proteins)

Definition
insoluble in water and stable (collagen, keratin, elastin)
Term

globular proteins

(functional proteins)

Definition
spherical, water soluble, functional (antibodies, hormones, enzymes)
Term
nucleic acids
Definition
largest molecules in body: carbon, hydrogen, oxygen, nitrogen, phosphorus
Term
nucelotide
Definition
structural base of nucleic acid consisting of three components: a nitrogen-containing base, a pentose sugar, and a phosphate group
Term
five major nitrogenous bases that contribute to nucleic structure
Definition
adenine, guanine, cytosine, thymine, and uracil
Term
purines: double ring
Definition
adenine and guanine
Term
pyrimidines: single ring
Definition
cytosine, thymine, and uracil
Term
pentose sugar
Definition
deoxyribose and ribose
Term

DNA deoxyribonucleic acid

Definition
genetic material; found in the cell nucleus; provides instructions for cellular protein synthesis and replicates itself before cell division
Term
DNA structure
Definition
double helix; cross linkage between pyrimidines and purines; A-T and G-C are complimentary bases
Term
RNA ribonucleic acid
Definition
carries DNA instructions, single strand, bases are A, G, C, and U
Term
Adenosine triphosphate (ATP) structure
Definition
adenine containing RNA nucleotide with two additional phosphates
Term
ATP functions- energy transfer
Definition
glucose is broken down; release of energy; energy from glucose is trapped in bonds of ATP
Term
ATP delivers energy to cellular processes
Definition
X + ATP -> XP + ADP
Term
also cleavage of phosphate from ATP releases energy + Pi
Definition
ATP -> ADP + Pi + energy
Term
cell theory
Definition

1. the cell is the structural and functional unit of life

2. the activity of an organism depends on the indivdual and collective activities of its cells

3. principle of complimentary

4. continuity of life has a cellular basis

Term
the cell: overview
Definition

all cells have a similar structure

plasma membrane, cytoplasm,organelles, nucleus

Term
plasma membrane
Definition
separates intracellular fluid from extracellular fluid
Term
cytoplasm
Definition
the intracellular fluid
Term
organelles
Definition
the small structures in the cytoplasm the perform specific functions
Term
Fluid mosaic model
Definition
depicts the PM as an exceedingly thin structure composed of a double layer, or bilayer, of lipid molecules with protein molecules dispersed in it
Term
Phospholipid bilayer
Definition
 a double layer of phospholipids lying tail to tail
Term
Heads are polar
Definition
hydrophilic (water loving)
Term
Tails are nonpolar
Definition
hydrophobic (water hating)
Term
Imbedded in the bilayer are...
Definition
cholesterol, glycolipids, proteins and glycoproteins
Term
Plasma Membrane inner and outer layers differ...
Definition
... in lipid content and type
Term
Glycolipids (5%)
Definition
found on the outer layer: (CHO + phospholipid)
Term
Cholesterol (20%)
Definition
acts to stabilize the membrane
Term
Unsaturated phospholipids
Definition
make up most of the PM; structure of unsaturated phospholipids causes the molecules to be loosely packed
Term
Lipid rafts
Definition
areas of more densely packed molecules formed with saturated fats such as sphingolipids and cholesterol
Term
proteins in plasma membrane are...
Definition
...imbedded/attached to PM; Account for about 50% of the PM; Responsible for most specialized functions 
Term
Two populations of proteins
Definition
integral proteins and peripheral proteins
Term
Integral proteins
Definition
firmly imbedded in the PM; Most integral proteins span the entire PM
Term

peripheral proteins

Definition
 loosely attached to PM; Help stabilize or modify shape (cytoskeleton); Enzyme or Enzyme systems; Serve as structural elements, linking sites, recognition sites
Term
Glycoproteins
Definition
(CHO + protein) are associated with the outer membrane
Term
Glycocalyx
Definition
CHO rich area surrounding the cell (glycolipids + glycoproteins)
Term
Functions of Membrane Proteins
Definition
Transport, Enzymatic activity(cause molecules to change shape), Receptors for signal transduction (sends something across membrane)Functions of Membrane Proteins, Intercellular adhesion, Cell-cell recognition, Attachment to cytoskeleton and extracellular matrix 
Term
Microvilli
Definition
multiple projections of PM act to increase the surface area
Term
three factors that bind cells together...
Definition

1. glycoprotein as an adhesive

2. contoured fit

3. special membrane junctions are formed

Term
membrane junctons
Definition
tight junctions, desmosomes, gap junctions
Term
tight jucntions
Definition
a series of integral proteins on adjacent cells fuse together (interlocking like snaps)
Term
desmosomes
Definition
anachoring junctions -- mechanical couplings scattered like rivets along the side of abutting cells that prevent their separation (linking)
Term
gap junction
Definition
a communicating juction between cells; channel proteins link together
Term
connexon
Definition
channel between cells; allows passage of ions and small hydrophilic molecules
Term
selective permeability
Definition
allows some subtances to pass while excluding others
Term
substances move across th PM two ways
Definition
actively and passively
Term
passive processes
Definition
requires no energy expenditure by the cell
Term
active processes
Definition
require energy expenditure by the cell (ATP)
Term
two types of passive transport
Definition
diffusion and filtration
Term
diffusion
Definition
the spreading of particles in a gas or soultion with a movement toward uniform distribution of particles
Term
simple diffusion
Definition
the unassisted transport across a plasma membrane of a lipid-soluble or very small particle
Term
facilitated diffusion
Definition
assisted diffusion, binds to proteins carriers in the membrane and is ferried across or moves through water-filled protein channels
Term
osmosis
Definition
diffusion of a solvent (water)
Term
aquaporins (AQP)
Definition
water-specific channels constructed by transmembrane proteins
Term
tonicity
Definition
the ability of a solution to change the shape or tone of cells by altering their internal water volume (tono= tension)
Term
isotonic
Definition
concentration equal so no net H2O exchange
Term
hypotonic
Definition

concentration onthe outside is lower than inside:

H2O -> in (cell swells up and bursts - lysis)

Term
hypertonic
Definition

concentration outside is higher than inside:

H2O -> out (cell shrinks - crenation)

Term
filtration
Definition
forces a solution through tha PM by hydrostatic pressure
Term
pressure gradient
Definition

gradient for filtration that pushes solute-containing fluid (filtrate) from a higher-pressure area to a lower-pressure area

Term

symport systems

Definition
when two transported substances move in the same direction
Term
aniport system
Definition
transported substances "wave to each other" as they cross the membrane in opposite direction
Term
primary active transport
Definition
energy to do work comes directly from hydrolysis of ATP (ex: Na-K pump)
Term
secondary active transport
Definition
transport is driven indirectly by energy stored in ionic gradients created by  operation of primary active transport pumps
Term
secondary transport systems
Definition
coupled systems; they move more than one substance at a time
Term
vesicular transport
Definition
the movement of fluids, large particles, and macromolecules across the plasma membrane
Term
exocytosis
Definition
moving substances from the interior to the extracellular space
Term
endocytosis
Definition
moving substances across the plasma membrane into the cell from the extracellular environment
Term
exocytosis process
Definition
an intracellular membrane bound vesicle; merges with PM and releases contents to extracellular fluid
Term
endocytosis process
Definition
a pocket of the PM buds into the cell; phagocytosis,  pinocytosis, receptor-meiated, clathrin-mediated
Term
phagocytosis
Definition
"cell eating" endosome formed is called a phagosome; contains large, solid material (bacteria/debris); merges with lysosome for chemical digestion
Term
pinocytosis process
Definition
"cell drinking" endosome formed contains liquid
Term
receptor mediated endocytosis
Definition

receptor on PM binds with target and the entire complex is formed into an endosome; clathrin coated or non clathrin coated (caveolae)

Term
membrane potential or voltage
Definition
electrical potential energy resulting from the separation of oppositely charged paticles (the electrical gradient acoss the PM); mostly a function of K+ and anionic proteins
Term
resting potential membrane
Definition
(-70mV) typically ranges from -50 to -100 mV
Term
electrochemical gradients
Definition
the combined deifference in concentration and charge; influences mthe distribution and direction of diffusion of ions
Term

cell-environment interaction

cells respond to...

Definition

extracellular chemicals, molecules that direct migration, and directly with other cells

Term
cell adhesion molecules (CAMs)
Definition
glycoproteins involved in embryonic development, wound repair, and immunity
Term

membrane receptors

Definition
integral proteins and glycoproteins
Term
contact signaling
Definition
the way cells recognize each other when they touch (development,immunity, etc)
Term
Electrical signaling
Definition
some PM receptors respond to changes in membrane potential by opening or closing ion channels. (Neural/muscle tissue)
Term
Chemical Signaling
Definition
occurs when a chemical binds with a PM receptor
Term
Ligand
Definition
signal chemical (i.e. Neurotransmitter, hormones paracrines)
Term
Operation of a G Protein
Definition
G-protein acts as relay to interact with a membrane bound enzyme or ion channel that generate intracellular signals (second messenger) such as cAMP and Ca2+
Term
Cytoplasm
Definition
cell material between PM and nucleus: Cytosol, inclusions and organelles
Term
Cytosol
Definition
viscous colloid/solution of proteins, salts, sugars etc.
Term
Inclusions
Definition
various chemical substances; lipid droplets in fat cells, glycogen in liver cells, etc.
Term
Mitochondria
Definition
supply most ATP; Double membrane: an outer sheath and an inner heavily folded (cristae); Multiple enzymes break down fuel for energy to form ATP from ADP: Aerobic respiration; Contain their own RNA and DNA. Can replicate.
Term
Ribosomes
Definition
made of protein + RNA
Term
RER is found in cells involved in protein synthesis
Definition
Secretory cellsLiver

Active immune system cells

Term
Smooth endoplasmic reticulum; (no protein synthesis) has enzymes in the SER membrane   
Definition
Lipid metabolism (liver)Steroid hormone synthesis (gonads)Absorption/transport of fats (intestine)Detoxification (liver and kidney)Glycogen breakdown (liver)Specialized SER in muscleSarcoplasmic Reticulum: Reservoir of Ca2+
Term
Golgi Apparatus
Definition
stacked and flattened membranous sacs. Modifies, concentrates and packages cellular products.Cis face; receives vesicles from RERTrans face; buds vesicles off into cytoplasm
Term
Lysosomes
Definition
contain digestive enzymes (acid hydrolases); digest contents of phagosomes, digesting cellular debris, normal tissue breakdown during development.
Term
Peroxisomes 
Definition
membranous sacs of potent enzymes (oxidases and catalases) – Neutralize free radicals Free radicals: highly reactive, have unpaired e- that disrupt biomoleculesOxidases convert free radicals to hydrogen peroxide then catalase converts H2O2 into water.
Term
Cytoskeleton
Definition
Acts as skeletal support and as cellular “muscle”. Microtubules  Intermediate fibers: Microfilaments
Term
Microtubules (largest)
Definition
 composed of tubulin (a spherical protein); radiate from the centrosome Organelles are anchored to microtubules and are moved around the cell by motor moleculesMotor proteins (kinesins and dyneins) pull organelles a long microtubules.
Term
Microfilaments (thinnest)
Definition
  strands of actin responsible for cell movement and shape changes.
Term
Intermediate fibers (tough insoluble)
Definition
  act as cables/guy wires.  Attach to Desmosomes
Term

Centrosome

Definition
microtubule organizing center contains centrioles
Term
Centrioles
Definition
paired organelles made up of nine triplets of microtubules; acts as foundation (basal body)
Term
Flagella
Definition

 move the cell:  nine doublets + central pair

sprout from basal bodies
Term
Cilia
Definition

move extracellular material across the surface of the cell:  nine doublets + central pair

sprout from basal bodies
Term
Dynein arms...
Definition
 bend cilia (power stroke) then release (recovery stroke)
Term

The Nucleus

Definition
Nuclear envelopeNucleoplasmNucleoliChromatin The cells genetic library and control center
Term
Nuclear envelope  
Definition
A double membrane with fluid between the layersOuter nuclear membrane is continuous with RERInner nuclear membrane is lined with structural protein (nuclear lamina)Nuclear pore complexes penetrate the membrane and allow large particle exchange between the Nucleus and Cytoplasm
Term
DNA
Definition
issues instructions to synthesize ribosomal RNA (rRNA)
Term
Chromatin: 
Definition
Unevenly staining threads in the nucleoplasmComposed of DNA + histone proteinsNucleosomes: a cluster of 8 histone molecules with DNA wrapped around them
Term
Chromosomes
Definition
highly condensed chromatin associated with cell division
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