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Veterinary Medicine
Undergraduate 2
04/19/2012

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Term
Heritability
Definition
Proportion of phenotypic variation due to additive gene effects
Term
Generation interval
Definition
average age of the parents when the offspring are born
Term
Non random mating
Definition
mating based on phenotypic resemblance
Term
postive assortment
Definition
best + best, worst + worst. Increases variation, produces extreme individuals
Term
negative assortment
Definition
best + worst. results in phenotypic uniformity
Term
Inbreeding
Definition
mating of individuals more closely related than under random mating
Term
Outbreeding
Definition
mating of genetically unrelated animals
Term
Inbreeding coefficient (F)
Definition
probability that the two genes at a locus in individual are identical by descent. Half the relationship between parents of the individual
Term
Identical by state
Definition
Homozygous alleles
Term
Identical by descent
Definition
both alleles from common ancestor
Term
F of full sibs/ parent-child
Definition
F= 1/4, genes in common= 1/2
Term
F of 1/2 sibs
Definition
F= 1/8, genes in common= 1/4
Term
F of 3rd degree (eg. 1st cousins)
Definition
F= 1/16, genes in common= 1/8
Term
F of 4th degee (eg. 1st cousins once removed)
Definition
F= 1/32, genes in common= 1/16
Term
F of 5th degree (eg. 2nd cousins)
Definition
F= 1/64, genes in common= 1/32
Term
Genetic effects of inbreeding
Definition
increases homozygosity (can be without a change in gene frequency)
If there is dominance; aa can be inferior and inbreeding will cause a decrease in performance
Alleles become 'fixed'
decrease in genetic variation
Term
Phenotypic effects of inbreeding
Definition
incerased incidence of 'throwbacks'
inbreeding depression
expression of deleterious recessive alleles
prepotency + decrease in phenotypic variation
Term
Inbreeding depression
Definition
Deciline in performance. The result of non-additive gene action (dominance). Worse in low heritable traits (repoduction, survivability).
Term
Prepotency
Definition
appears or performs like one of either parent. Most likely to result of individuals homozygous loci contain cheifly dominant alleles
Term
Change in F per generation
Definition
1/8Nm + 1/8Nf
Nm & Nf = number of males/females per generation
Term
Change in F per year
Definition
1/8nmL^2 + 1/8nfL^2
nm & nf = number of new males/females that enter population each year
L = generation interval
nm = Nm/L
Term
Inbreeding high
Definition
F> 0.2
Term
appropriate change in F/yr for production animals
Definition
change in F at <0.5%/yr
Term
appropriate change in F/yr for endanged species
Definition
change in F at <1%/yr
Term
Advantages of inbreeding
Definition
increases uniformity in population
study inheritance pattern of recessive traits
increase hybrid vigour (crossing of 2 divergen inbred lines)
Term
linebreeding
Definition
constructing pedigrees so that animals are closely related to some 'superior' ancestor
Term
Avoiding inbreeding
Definition
increase population size
increase the number of males used
bring in outside genetic material
consult with animal breeder
Term
Out cross
Definition
unrelated individuals within breed
Term
Crossbreeding
Definition
animals from different breeds
Term
species hybridisation
Definition
individuals from different species
Term
Incross
Definition
two inbred lines belonging to the same breed
Term
In-crossbred
Definition
two inbred lines belonging to different breeds
Term
Top cross
Definition
inbred males X females of outbred population
Term
backcross
Definition
F1 female X one of intial breeds
Maternal heterosis + 50% individual heterosis
Term
grading up/ upgrading
Definition
backcrossing for successive generations to same intial breed
Term
Effects of outbreeding
Definition
increases heterozygosity
masks expression of deleterious recessive genes
hybrid vigour/ heterosis = increased mean performance of parents
Term
Advantages of outbreeding
Definition
add hybrid vigour
breed complementarity
avoid inbreeding depression
mask effects of deleterious recessive alleles
Term
Heterosis
Definition
deviation of the average of reciprocal crossbred progeny from the average of the parental breeds
Term
euhetrosis
Definition
hetrosis of fitness traits
Term
luxuriance
Definition
heterosis of vegetative growth
Term
Individual heterosis
Definition
hybrid vigour attributed to heterozygosity of the same outbred individuals upon whom the traits are measured
Term
Maternal heterosis
Definition
benefits of heterosis in traits accruing to the offspring of the crossbred female, rather than to the female herself. eg. individual milk production in Angus-hereford cows could be reflected as maternal hetrosis in pre-weaning growth in their progeny with Simmental bulls
Term
Paternal heterosis
Definition
hybrid vigour attributed to the sires, but accrues to the offspring. Eg. cross-bred bulls contribute to increased libido and higher survival rate of crossbred embryos, thereby resulting in more calves being born.
Term
Genetic causes of heterosis
Definition
-non-additive gene action-
complete dominance, over dominance, epistasis
Term
Factors affecting heterosis
Definition
reciprocal crosses
breeds involved in cross
genetic and envorinmental interaction
differences among traits
breed complementarity
Term
Basic principals of heterosis
Definition
max H seen in F1
H proportional to proportion of heterozygosity
H 1/2 in F2 compared to F1
no further decrease in F3; hardy-weinberg equlibrium

F1 backcrossed to parent breed; H 1/2
BC1 backcrossed to breed A there will be further decrease in H
Therefore it is better to keep pure breds for mating rather than backcrossing to parental breeds
Term
Fixed % / specific crossing
Definition
2 breeds crossed, F1 sold for slaughter or other commercial use. 100% individual heterosis.
Term
3-way cross
Definition
ABxC
50% of breed C + 25% of A&B inheritance
100% IH + maternal H
Term
4-way cross
Definition
ABxCD
25% inheritance of each breed
100% IH + maternal and paternal H
Term
Variable % crossing
Definition
Cris-crossing:
systemic crossbreeding with 2 breeds
maintaing 2/3 of H seen in F1 generation

Rotational crossing:
4th generation will show 6/7 H of F1 generation
only sires required from pure bred matings, crossbred dams self replacing.
Large variation in breed composiion between generations = marketing and management problems
Term
Composit/synthetic breeds
Definition
express less heterosis than specific of sequential
the more breeds used; the more teterosis that will be exhibited
Term
Complementarity
Definition
Choosing the right breeds to complement each other in a cross allows the best collective performance in all traits affecting the objective of the farming enterprise
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