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Term 1, Biochem Lecture #16 & 17
Digestion & Absorption
18
Medical
Graduate
09/12/2009

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Cards

Term
Three characteristics of Albumin
Definition
This protein is synthesized in the liver, acts as a specific transport protein in the blood and is a regulator of blood osmolality
Term
This condition is required to activate pepsinogen
Definition
A low pH/high [H+] is necessary to active this digestive enzyme
Term
Two common examples of pancreatic enzymes
Definition
Proteases and phospholipases are two examples of these
Term
Abnormal or pre-mature proteolytic activation of pancreatic enzymes can lead to this condition
Definition
Pancreatitis is a consequence of this
Term
Pancreatic enzymes are normally active only at this location
Definition
These enzymes are only active in the lumen of the small intestine
Term
Alpha-amylase is found at these two locations in the body
Definition
The oral cavity and pancreas have isozyme
Term
These intestinal enzymes are bound to the mucosal cell membrane
Definition
Isomaltase, maltase, lactase and sucrase are found here
Term
These are 4 pancreatic zymogens
Definition
pro-elastase, pro-carboxypeptidae, trypsinogen and chymotrypsinogen
Term
These enzymes are found in the small intestine
Definition
Amino peptidases are found here
Term
General degredation pathway of dietary purines
Definition
broken down by cells of intestinal mucosa, converted to uric acid released into the blood, excreted by the kidney
Term
Lipid digestion requires this
Definition
Dietary bile salts are needed by this organ
Term
These two components are important for the solubility of cholesterol in bile
Definition
Conjugated bile salts and Phosphitidylcholine are important for this
Term
Chylomicrons absorb these molecules
Definition
Fatty acids and fat-soluble vitamins are taken up by these lipoproteins
Term
Deficiency in conjugated bile salts leads to this condition
Definition
Gallstones and Steatorrhea
Term
Deficiency in Vitamin A leads to this condition
Definition
Night blindness is a consequence of this dietary deficiency
Term
The oral cavity is where digestion of these molecules begin
Definition
Carbohydrates and TAG (w/ medium chain fatty acids) start their breakdown here
Term
A general pathway for DNA/RNA degredation in digestion
Definition
Stomach: Low pH denatures DNA/RNA
Small intestine (enzymes from pancreas):
- Nucleases break down strands to
oligonuceotides
- Phosphodiesterases break down
oligonucleotides to mononucletides
- Nucleotidases break down
mononucleotides to nucleosides
- Nucleosideases break down nucleosides
into nucleotides
- Nitrogenous bases are absorbed into
intestinal mucosal cells where the
majority of purines are converted
into uric acid
Term
A general pathway for lipid degradation in digestion
Definition
Small intestine:
Bile salts emulsify lipids and pancreatic enzymes degrade them to their primary products -

Free fatty acids
2-monoacylglycerol
cholesterol

Primary components are combined with protein to form chylomicrons which are then transported into the lymphatic system
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