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Details

TBL 2
Epithelium, Connective Tissue, and Skin
43
Medical
Graduate
11/11/2011

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Cards

Term
Basal Lamina
Definition
Type IV Collagen
Term
Reticular Lamina
Definition
Type III Collagen
Term
Keratinocyte Turnover
Definition
20-75 days
Term
Langerhans Cells Location
Definition
Superficial layers of epidermis
Term
Merkel Cell Function
Definition
Mechanoreceptor.
Term
Pacinian Corpuscle location
Definition
Hypodermis
Term
Meissner's Corpuscle location
Definition
Dermal Papillae of thick skin.
Term
Apocrine glands
Definition
Odiferous sweat glands
Term
Eccrine glands
Definition
Heat Loss sweat glands
Term
Why is loose connective tissue a common site of edema formation?
Definition
Much of the body's tissue fluid and the microcirculation is found here.
Term
Why do type I collagen factors have high tensile strength?
Definition
Highly organized parallel fibril structure that is reinforced by hydrogen bonds and crosslinks.
Term
Why do plasma cells accumulate in connective tissue underlying the intestinal epithelium?
Definition
They are activated when ingested infectious agents cross the gut.
Term
A ready source of metabolic fuel.
Definition
Fat in adipose tissue.
Term
Stimuli of white fat
Definition
Hormones and sympathetics.
Term
Stimuli of brown fat
Definition
Sympathetics.
Term
Function of white fat.
Definition
To meet energy needs of the body, esp during fasting
Term
Function of brown fat
Definition
To generate heat.
Term
How do keratinocytes counteract mechanical forces that could cause abrasive injury?
Definition
Intercellular junctions, and extensive internal cytoskeleton of tonofilaments and intermediate filaments.
Term
Why is the number of Langerhans cells increased at sites of contact dermatitis?
Definition
Because they are dendritic cells that respond to inflammation.
Term
Nociceptor's structure
Definition
Free Nerve Ending
Term
Nociceptor's function
Definition
Sense Pain
Term
How do "goose bumps" form?
Definition
Arrector muscles cause slight erection of the associated hair.
Term
Balding
Definition
When follicles cease to be formed and hair cannot be replaced.
Term
Tanning
Definition
Melanocytes increase synthesis of melanin in response to UV light.
Term
Acrid or Musky Odor
Definition
Apocrine secretions coming into contact with bacterial decomposition
Term
Why are epithelia susceptible to tumor formation?
Definition
High mitotic index.
Term
Carcinoma origin
Definition
covering/lining epithelium
Term
Adenocarcinoma origin
Definition
glandular epithelium
Term
Epithelial Dysplasia
Definition
Maturation abnormality. Inactivation of tumor suppression genes.
Term
Epithelial Metaplasia
Definition
Cell-type conversion, usually a response to stress or irritation.
Term
Squamous metaplasia
Definition
Conversion to nonkeratinized stratified epithelium: Cervix/Respiratory tract
Term
Risk factors for Transitional Cell Carcinoma
Definition
Cigarette smoking, occupational exposure to organic compounds like benzidine and absestos.
Term
Presenting Symptoms of Transitional Cell Carcinoma
Definition
Hematuria, pain from gradual obstruction
Term
Most common adult sarcoma
Definition
Malignant fibrous histiocytoma
Term
Typical sites of malignant fibrous histiocytoma formation, and metastasis
Definition
Deep fascia, soft tissues of neck or extremities, and skeletal muscle. Metastasis to lung, bone, or liver.
Term
Vit c on type I collagen fibers
Definition
Hydroxylation of proline and lysine residues
Term
Marfan Syndrome
Definition
Mitral valve prolapse, weakening of the tunica media of aorta leading to spontaneous rupture, floppy valve
Term
Most Common Plasma Cell Neoplasm
Definition
Multiple Myeloma
Term
Obesity
Definition
leads to serious disorders such as hypertension, diabetes, MIs, poor surgical outcomes.
Term
Basal Cell Carcinoma
Definition
Most common type of skin cancer. Rarely metastasizes.
Term
Squamous Cell Carcinoma
Definition
Second most common type of skin cancer. More dangerous than basal cell. Sun-exposed skin.
Term
Blistering disorders
Definition
Result from disrupted epidermal adhesion and attachment that may be caused by autoantibodies.
Term
Acne Vulgaris
Definition
Chronic inflammatory disease of the pilosebaceous unit. dev't of keratin plugs that block sebum. Neutrophils attracted form a follicular abscess.
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