Term
| What 3 things can be affected to block proliferation? |
|
Definition
-Blocking the cell surface receptor
-Targeting Tyr kinase
-Targeting mTOR |
|
|
Term
| How are Cell surface receptors Ab administered? |
|
Definition
|
|
Term
| What are the disadvantages of cell surface receptor Ab? |
|
Definition
Large mass-> poor tumor penetration
Heterogeneous/insufficient tumor Ag expression
Specificity - normal cells express Ag
Mouse Ab and derivative ofter induce human anti-mouse Ab - treatment loses efficacy |
|
|
Term
| What is the mechanism of cell surface receptor Ab? |
|
Definition
| Complement dependent cytotoxicity |
|
|
Term
|
Definition
Breast
-apoptosis, ADCC
-EGFR-2, Her-2/neu |
|
|
Term
|
Definition
Colorectal
Non-small-cell Lung Carcinoma
Renal
Pancreatic
-Antiangiogenesis, neovascularization
-VEGF block
(**GI perforation**) |
|
|
Term
|
Definition
Non-Hodgkins Lymphoma
Chronic Lymphocytic Leukemia
RA
-apoptosis, ADCC, CDC
-Targets CD20
(Vaccination?) |
|
|
Term
|
Definition
Chronic Lymphocytic Lymphoma
Stem Cell Prep for transplantation
-Apoptosis, ADCC, CDC
-Targets CD-52 |
|
|
Term
| What Antibody therapies are used to treat Colorectal Cancer? |
|
Definition
Cetuximab (EGFR-1/Her-1)
Panitumuma (EGFR-1/Her-1)
Bevacizumab (VEGF) |
|
|
Term
| What Antibody treatments are used to treat Non-Hodgkins Lymphoma? |
|
Definition
Rituximab (CD20)
Ibritumomab Tiuxetan (CD20)
Tositumomab (CD20)
|
|
|
Term
| What antibody treatments are used to treat Chronic Lympocytic Leukemia? |
|
Definition
Rituximab (CD20)
Ofatumumab (CD20)
Alemtuzumab (CD52) |
|
|
Term
| What antibody treatments are used for stem cell preparation for transplantation? |
|
Definition
Alemtuzumab (CD52)
Tositumomamab (CD20) |
|
|
Term
| What Agents have antibodies to VEGFR? |
|
Definition
|
|
Term
| What agent has antibodies to CD20? |
|
Definition
|
|
Term
| What agents have antibodies to CD52? |
|
Definition
|
|
Term
| What are the problems with Tyrosine Kinase Inhibitors and their specificity? |
|
Definition
TKIs may target TK involved in normal body function
Many TK's are structurally related
Most TKI's act on ATP binding sites which are highly conserved |
|
|
Term
|
Definition
Gefitinib Erlotinib
(GEL) |
|
|
Term
| What tumors are all the EGFR TKIs used against? |
|
Definition
|
|
Term
| What are Gefitinib and Erlotinib used for? (EGFR TKIs) |
|
Definition
Breast
Ovarian
NSCLC
mesothelioma
colorectal
head & neck cancers |
|
|
Term
| What are the BCR-ABL TKIs? |
|
Definition
|
|
Term
What cancers are the BCR-ABL TKIs effective against?
(Imatinib, Dasatinib) |
|
Definition
Chronic Myelogenous Leukemia
Acute Lymphoblastic Leukemia |
|
|
Term
| If a patient is resistant to Imatinib what agent can be used? why? |
|
Definition
Dasatinib
due to different binding |
|
|
Term
|
Definition
|
|
Term
What are all of the VEGF TKIs effective against?
(Sunitinib) |
|
Definition
|
|
Term
| What VEGF TKI is effective against GI stromal cancer? |
|
Definition
|
|
Term
| What VEGF TKIs may cause QT Prolongation? |
|
Definition
|
|
Term
| What is the mTOR Inhibitor? |
|
Definition
|
|
Term
| What is the antiviral and antineoplastic activity of IFN-alpha-2a? |
|
Definition
Arrests cell cycle in G0
Induces apoptosis
Induces IR (CTLs, NK cells) |
|
|
Term
| What is done to IFN-alpha-2a to make it better tolerated and longer lasting? |
|
Definition
|
|
Term
| What are the side effects of INF-alpha-2a? |
|
Definition
Neuropsychiatric
Extended Flu-like symptoms |
|
|
Term
| What is the mechanism of Bortezomib? |
|
Definition
| Inhibits proteosome function-> incr IkB-> incr IkB bound to NFkB-> decreased transcription of proliferative and antiapoptotic genes-> apoptosis, growth inhibition, reduced angiogenesis |
|
|
Term
| what other proteins are affected by Bortezomib? |
|
Definition
Cyclin-dependent kinases
p53
Bax
Cyclins |
|
|
Term
| What are the GnRH Agonists? |
|
Definition
|
|
Term
| What Hormone agents are used to treat metastasis for prostatic tumors? |
|
Definition
|
|
Term
| What is the Androgen Receptor Blockers? Where does it bind? |
|
Definition
Flutamide
Irreversibly inhibit androgen binding at hypothalamus, pituitary, and prostate |
|
|
Term
| What are the Selective estrogen receptor modulators? |
|
Definition
|
|
Term
| What do Both the SERMs have a blackbox warning against? (Tamoxifen, Raloxifene) |
|
Definition
| Thromboembolic disease, Stroke |
|
|
Term
| What does Tamoxifen have a blackbox warning against? |
|
Definition
Endometrial Hypertrophy and cancer
vaginal bleeding
thomboembolic disease
Stroke |
|
|
Term
| What are the Aromatase Inhibitors? |
|
Definition
Anastrazole
Letrozole
Exmestane |
|
|
Term
How do the Aromatase Inhibitors work?
(Anastrazole, Letrozole, Exmestane) |
|
Definition
| Interrupt normal metabolism of estrogen/testosterone - Bind to heme center of CYP protein |
|
|
Term
| What are the 2 types of Aromatase Inhibitors? |
|
Definition
Non-Steroidal - reversible
Steroidal - irreversible |
|
|
