Term
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Definition
| The antigen recognition complex b/w a T cell & an antigen presenting cell |
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Term
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Definition
| The receptor on a helper T cell that interacts with the "self" component of an antigen presenting cell, & is associated with Lck tyrosine kinase |
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Term
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Definition
| The receptor on a cytotoxic T lymphocyte that interacts with the "self" component of an antigen presenting cell, & is associated with Lck tyrosine kinase |
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Term
| CD 28: B7.1/B7.2 (CD 80/86) |
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Definition
| The co-stimulatory activating interaction b/w an antigen presenting cell & a T cell providing a second signal of activation to the T cell. |
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Term
| CTLA-4 (CD152): B7.1/B7.2 (CD 80/86) |
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Definition
| The negative co-stimulatory activating interaction b/w an antigen presenting cell & a T cell inhibiting T cell activation & proliferation |
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Term
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Definition
| CD 40 ligand is on the T cell & CD 40 is on the B cell. The interaction of the 2 receptors drives the resting B cell into the cycle of cell division. |
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Term
| Fas (CD 95): FasL (CD 95L) |
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Definition
| Activated cytotoxic T cells express Fas Ligand on the surface, which binds to the Fas ligand on the target cell. This interaction sends signals to the cell to undergo apoptosis. |
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Term
| LFA 1 (CD 11a/18): ICAM-1/2 (CD 54/CD 102) |
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Definition
| Cell adhesion binding b/w an antigen presenting cell & a T cell that is localized in the peripheral supramolecular activation complex of an immunological synapse. |
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Term
| CD2 (LFA-2): LFA-3 (CD 58) |
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Definition
| CD2 on the T cell binds with LFA-3 on the dendritic cell. Adhesion is stregthened by the interaction. |
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Term
| DC-SIGN (CD 209): ICAM-3 (CD 50) |
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Definition
| Cell adhesion b/w an activated dendritic cell & a T cell. The human immunodeficiency virus surface glycoproteins 120 also attaches to the adhesion molecule on the activated dendritic cell. |
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Term
| VLA-4 (CD 49d/CD29): VCAM-1 (CD 106) |
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Definition
| Integrin that is expressed on the surface of an activated T cell, that promotes migration from the vascular system to an inflamed location of nonvascular tissue. |
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Term
| L-selectin (CD 62L): sialyl Lewis (CD15) on GlyCAM-1 and CD 34 |
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Definition
| Receptor on circulating T cells that binds to structures on the high endothelial venules within 2° lymphoid tissue as a mean of homing. |
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Term
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Definition
| Autocrine action of a T cell leading to proliferation & differentiation of an antigen activated population |
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Term
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Definition
| Cytokine produced by TH1 cells, NK cells & cytotoxic T lymphocytes that enhances cell mediated immunity & production of the other subclasses of IgG as well as IgA & IgE |
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Term
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Definition
| Cytokine produced by TH2 cells & mast cells that enhances production of human IgG2, IgG4, IgA &IgE, but suppresses cell-mediatd immunity & production of IgG1 & IgG3. |
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Term
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Definition
| Cytokine secreted by CD4 TH2 cells, inhibit macrophage activation |
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Term
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Definition
| Produced by macrophages and activate inductio of TH1 cells, activate NK cells |
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Term
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Definition
| downregulates inflammatory cytokine production, promotes wound healing responses & scar tissue, growth inhibition, inhibits macrophage activation, |
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