Term
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Definition
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Term
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Definition
drug-H + NADH + H+ + O2 yields
drug-OH + NAD+ + H2O |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| dealkylation and deamination |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| dehalogenation requires a |
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Definition
-lipid/nucleic acid
-forms a lipid free radical |
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Term
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Definition
-reduction
-hydrolysis
-FMO
-MAO
-DAO
-XO
-Alcohol/Aldehyde dehydrogenase |
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Term
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Definition
-catalyze oxygenation of NPS
-many different isoforms
-require O2,NADPH,FAD |
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Term
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Definition
-mitochondrial enzyme
-endogenous substrates are neurotransmitters |
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Term
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Definition
| -substrates include histamine and polyamines |
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Term
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Definition
-substrates are purines
-hypoxanthine to xanthine to uric acid
-leads to gout |
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Term
| alcohol/aldehyde dehydrogenase |
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Definition
| -non-specific enzymes in soluble fraction of liver |
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Term
| 1. how the liver metabolizes alcohol |
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Definition
| -ethanol + NAD+ yields acetaldehyde + NADH + H+ |
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Term
| 2. how the liver metabolizes alcohol |
|
Definition
| -acetaldehyde + NAD+ yields acetic acid + NADH + H+ |
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Term
| 3.how liver metabolizes alcohol |
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Definition
| -acetic acid yields water and CO2 |
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Term
| inhibits aldehyde dehydrogenase |
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Definition
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