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Systems Pharmacology
Nuclear Receptors
8
Biology
Graduate
11/13/2011

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Cards

Term
nuclear receptor types
Definition
-transcriptional regulation
-steroidal/nonsteroidal
Term
steroid hormones
Definition
small and hydrophobic
Term
4 regions of steroid receptors
Definition
-variable domain
-DNA binding domain
-Hinge region
-Hormone binding domain
Term
variable domain
Definition
N terminus
Term
DNA binding domain
Definition
-controls which gene will be activated
-interacts with hormone response element (HRE)
Term
hinge region
Definition
-controls movement of receptor to nucleus
Term
hormone binding domain
Definition
can include nuclear localization signal
Term
HSP
Definition
-bound to steroid receptors
-hides NLS
-when steroid binds, it is released
-uncovers NLS
-enters nucleus
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