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Systems Pharmacology II
Intro and Symptoms
15
Biology
Graduate
03/24/2012

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Term
schizophrenia
Definition
-major psychiatric disorder that alters an individuals perception, thoughts, affects, and behavior
-unknown cause (no gene)
Term
etiology
Definition
-some case have anatomical abnormalities
-large ventricles
-brain asymmetry
-atrophy of cortical layers
-decreased basal ganglia size
-all due to myelin defects?
-visible before clinical symptoms occur (malfunction of oligodendrocyte genes)
-changes in number of connections not number of cells
Term
area of brain changed
Definition
-frontal loss of grey matter
-temporal prevent day to day memories linking emotions
-parietal hallucinations/illusion
Term
symptoms
Definition
-positive
-negative
-cognitive
-aggressive/hostile
-depressive/anxious
Term
positive symptoms
Definition
-delusions (fixed false beliefs)
-hallucinations (sensory experiences devoid of actual stimuli, usually auditory)
-illusions (misinterpretation of a true sensation)
-disorganized language and speech
-disordered thinking
-agitation
-catatonic (slow) behavior
Term
negative symptoms
Definition
-psychomotor retardation
-affective flattening (low emotion)
-avolition (dec. goal directed behavior)
-anhedonia (lack of pleasure)
-alogia (poverty of speech)
-loss of emotional connectedness
-loss of executive functions
Term
cognitive symptoms
Definition
-odd use of language (incoherence, loose associations, neologisms)
-impaired attention and information processing
-impaired working memory
-cannot modulate behavior based on social cues
Term
aggressive and hostile symptoms
Definition
-problems with impulse control
-overt hostility (verbal and physical abuse)
-self injurious behaviors (10% commit suicide)
Term
other symptoms
Definition
-poor hygiene
-sleep/appetite disturbances
-comorbid disease states (50-90% smoke)
Term
subtypes
Definition
-paranoid
-disorganized
-catatonic
-residual
-undifferentiated
Term
paranoid schizo
Definition
delusions and hallucinations are present but disorganized behavior, speech, and affective flattening are absent
Term
disorganized schizo
Definition
-flat affect, disorganized speech and behavior are present
Term
catatonic schizo
Definition
-immobility
-stupor
-purposeless movement
-extreme negativism
-mutism
-bizarre postures
-repetitive imitations
Term
residual schizo
Definition
-negative symptoms are present at a low intensity only
Term
undifferentiated schizo
Definition
-psychotic symptoms are present but the criteria for other types not met
-mixtures are common
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