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Systems Pharmacology II
Chemical Organization of the Brain
12
Biology
Graduate
02/23/2012

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Term
dopaminergic systems
Definition
-mesocortical
-mesolimbic
-nigrostriatal
-tuberofundibular
Term
mesocortical pathway
Definition
-originates in the VTA and projects to the frontal cortex and surrounding structures
-dysfunction may lead to schizophrenia symptoms
Term
mesolimbic pathway
Definition
-originates in VTA and projects to nucleus accmbens
-addiction
Term
nigrostriatal pathway
Definition
-projections from substantia nigra to the striatum
-involved in motor control
-degredation of the neurons in this pathway is associated with symptoms of Parkinsons
Term
tuberofundibular pathway
Definition
-connects hypothalamus to the pituitary gland
-influences secretion of hormones such as prolactin
Term
cholinergic system
Definition
-basal forebrain pathway
-mesoponitine pathway
Term
basal forebrain pathway
Definition
-projections from the nucleus basilis to the cortex
-projections to the hippocampus
-important in learning and memory-Alzheimers
Term
Mesopontine pathway
Definition
-projections originating from pons to the thalamus and forebrain
-descending pathways to the reticular formation and associated structures
-important for wakefulness and REM sleep
Term
serotonergic system
Definition
-ascending/descending Raphe projections
-Raphe projections are important for sensory processing and homeostasis
-roles in psychotic behaviors, depression, anxiety, eating disorders
Term
ascending Raphe
Definition
-rostral to limbic, thalamus, striatum, and cerebral cortex
Term
descending Raphe projections
Definition
-caudal pathways project to spinal cord
Term
norandrenergic system
Definition
-locus coeruleus project
-lateral tegmental projections
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