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Systems Pharmacology II
Nervous System Fundamentals
23
Biology
Graduate
01/28/2012

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Term
3 functions of the nervous system
Definition
-collect info
-process info
-elicit response
Term
astrocytes
Definition
-most abundant glial cell
-anchor neurons to capillaries
-guide migration of neurons and synapse formation
-mop up leaked ions and neurotransmitters
-some release neurotransmitters
-tell capillaries to form tight junctions between BBB
Term
microglia
Definition
-monitor health of neurons
-migrate towards injured neurons
-transform into macrophages and engulf and digest dead neurons
Term
ependymal cells
Definition
-line cavities of brain and spinal cord
-barrier between nervous tissue and CSF
-ciliated
-help circulate CSF and cushion the brain and spinal cord
Term
oligodendrocytes
Definition
-CNS
-branched
-form myelin sheath
-myelinate many axons at once
Term
Schwann cells
Definition
-surround large nerve fibers
-for myelin sheath
Term
white matter
Definition
-myelinated
-axons
Term
gray matter
Definition
-unmyelinated
-cell bodies
Term
why myelin sheath contains little protein?
Definition
-anchor axon and rings together
Term
nuclei
Definition
-groups of cell bodies in CNS
Term
ganglia
Definition
-groups of cell bodies in PNS
Term
tracts
Definition
-bundle of axons in CNS
Term
nerves
Definition
-bundles of axons in PNS
Term
Nissi bodies
Definition
-RER
Term
axon hillock
Definition
triangular region where cell body meets axon
Term
axons depend on this for proteins
Definition
-soma (cell body)
Term
important neuronal characteristics
Definition
-extreme longevity (last an entire lifetime)
-amitotic (except olfactory and hippocampus)
-high metabolic rate (needs a lot of glucose and oxygen)
Term
20% of body E goes to
Definition
brain
Term
PET scan
Definition
-uses labeled glucose
Term
fMRI
Definition
-uses oxygen uptake
Term
multipolar
Definition
-many processes extend from cell body
-motor and interneurons
-Purkinje cell of cerebellum
-pyramidal cell
Term
bipolar
Definition
-2 processes extend from cell body
-sensory
Term
unipolar
Definition
-one process extends from cell body
-sensory
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