Term
| Which transcription factor controls much of male differentiation? What gene codes for this transcription factor? |
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Definition
Transcription factor - Testes determining factor (TDF)
Gene - SRY |
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Term
| How does the undifferentiated gonad develop in males and females? |
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Definition
Female - the cortex develops into the ovary and the medulla regresses
Male - the cortex regresses and the medulla develops into the testes |
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Term
| In males, how do androgens affect the mesonephros and Wolffian ducts? |
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Definition
Mesonephros - differentiates into the epididymis
Wolffian duct - differentiates into the vas deferens, seminal vesicles, and the ejaculatory duct |
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Term
| Where is antimullerian hormone produced? What does it do? |
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Definition
It is secreted by the testes
AMH causes regression of the Mullerian Duct |
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Term
| Early in development, is androgen production by the testes dependent upon pituitary hormones? |
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Definition
No
Human chorionic gonadotropin from the placenta stimulates production
Later in gestation, LH is required to support testicular androgen production |
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Term
| True or False: Testosterone can directly act upon the external genitalia of the male |
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Definition
| False; testosterone must be transformed into dihydrotestosterone (DHT) before it can act on the external genitalia of the male |
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Term
| What converts testosterone to DHT? |
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Definition
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Term
| What is responsible for the masculinization of the male brain? |
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Definition
| Estrone and estradiol; Aromatase is present within the brain tissue which converts testosterone to estrone and estradiol |
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Term
| Which hormone stimulates the production of Leydig cells? |
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Definition
LH
FSH stimulates the Sertoli cells which begin to support spermatogenesis |
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Term
| In humans, how long does spermatogenesis take? |
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Definition
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Term
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Definition
| Polypeptide hormones produced by Sertoli cells that stimulate FSH release by the anterior pituitary |
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Term
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Definition
| Glycoproteins that bind to activin and inhibit its ability to stimulate FSH by the pituitary gland; they can be thought of as FSH suppressing compounds |
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Term
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Definition
| Polypeptide hormones that is released from the Sertoli cells which signals back to the pituitary gland and reduces the release of FSH |
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