Term
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Definition
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Term
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Definition
| Polar, decreased CNS activity |
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Term
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Definition
| Metabolism by catechol-O-methyl transferase (-OH → -OCH3) |
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Term
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Definition
| No metabolism by monoamine oxidase (-NH → -N-OH) |
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Term
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Definition
N-alkyl group: β activity
β hydroxyl: polar, decreased CNS activity
Catechol OH: metabolism by catechol-O-methyl transferase (-OH → -OCH3)
Metabolism by monoamine oxidase (-NH → -N-OH)
No steric hindrance by ɑ carbon bulky group |
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Term
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Definition
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Term
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Definition
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Term
Epinephrine
Blood pressure tracing |
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Definition
Increase (β1)
Decrease (β2)
Increase (ɑ1) |
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Term
Epinephrine
Anti-asthmatic effect? |
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Definition
| Vasoconstriction and bronchiolar dilation to relieve anaphylactic shock |
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Term
Epinephrine
Metabolism? Administration? |
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Definition
Rapidly metabolized in liver
Intravenous injection usually |
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Term
Ephedrine
Adrenergic activity? Structure? |
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Definition
ɑβ
No catechol –OH groups
No CMT metabolism
β-OH and ɑ-CH3
Decreased CNS activity, no MAO metabolism
Longer acting
Release of NE at adrenergic receptors |
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Term
Methamphetamine
Structure? |
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Definition
No catechol –OH groups
No CMT metabolism
ɑ-CH3
No MAO metabolism
No β-OH
Lipophilic, CNS activity |
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Term
|
Definition
Uterine contractions via ɑ receptors
Premature labour |
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Term
Norepinephrine
Adrenergic activity? |
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Definition
(ɑ, β1)
No β2 activity
Smooth muscle constriction & increase in B.P. |
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Term
Norepinephrine
Blood pressure tracing? |
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Definition
Increase
Smooth muscle constriction & increase in B.P. |
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Term
| Isopropyl norepinephrine (INE) |
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Definition
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Term
Isopropyl norepinephrine (INE)
Blood pressure tracing? |
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Definition
Acute increase in B.P. via β1
Decrease in B.P. via β2 |
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Term
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Definition
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Term
Dopamine
Adrenergic activity? |
|
Definition
β1
Acts on dopamine and beta receptor
Increase in B.P. via activation of RAAS |
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Term
Salbutamol
Adrenergic activity? |
|
Definition
β2
Bronchiolar relaxation to treat asthma
Usually inhaled |
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Term
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Definition
Tyrosine → tyramine via decarboxylation
Release NE into synaptic cleft
Constriction of blood vessels within skull |
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Term
Amphetamine
Adrenergic activity? Structure? Adverse Effects? |
|
Definition
Release NE from storage sites
ɑ and β1 actions
Peripheral and CNS effect, no β-OH group
Lack of polarity → lipid soluble
Prevent sleep, reduce appetite
Sympathetic stimulation in CNS
Impact on growth |
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Term
Cocaine
Adrenergic activity? Adverse effects? |
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Definition
Inhibits reuptake of NE
Increases potency of NE peripherally and centrally
Left-shift in dose/response curve
Vasoconstriction → heart attack |
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Term
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Definition
CNS stimulant
Less impact on growth than amphetamine
ADHD |
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