Term
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Definition
Interferes with bacterial folic acid synthesis.
SMZ: inhibits dihydrofolic acid formation from para-aminobenzoic acid
TMP: inhibits dihydrofoilc acid reduction to tetrahydrofolate. |
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Term
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Definition
Sulfamethoxazole and trimethoprim (Bactrim, Septra)
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Term
| What is the single strength (SS) and double strength (DS) doses? |
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Definition
SS: 400 mg SMZ/80 mg TMP
DS: 800 mg SMZ/ 160 mg TMP
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Term
| What is the ration of SMZ to TMP for Septra? |
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Definition
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Term
| What are some contraindications for sulfonamides? |
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Definition
Sufla Allergy
Pregnancy (at term)
Anemia due to folate deficiency |
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Term
| Bactrim suspension should be stored at what temperature? |
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Definition
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Term
| Sulfonamides are moderate inhibitors of what? |
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Definition
2C8/9; therefore caution when administering with warfarin
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Term
| sulfonamides may increase levels of sulfonylureas & phenytoin |
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Definition
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